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Is twice daily LF-rTMS a viable treatment option for treatment-resistant OCD? Results from an open-label feasibility study

Hannelore Tandt (UGent) , Nele Van de Velde (UGent) , Sara De Witte (UGent) , Kurt Audenaert (UGent) , Chris Baeken (UGent) and Gilbert Lemmens (UGent)
(2021) EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 271(1). p.211-214
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Abstract
Several reports point to the beneficial effects of repetitive transcranial magnetic stimulation (rTMS) in the treatment of resistant obsessive-compulsive disorder (OCD). This study aimed to evaluate the safety and efficacy of rTMS targeting the dmPFC in the treatment of treatment-resistant OCD patients.Twelve patients received 20 sessions of low-frequency (LF) rTMS (1 Hz, 1200 pulses) in a twice daily protocol during 10 weekdays. Y-BOCS and IDS scores modestly but significantly decreased after treatment and at follow-up and HADS anxiety improved at follow-up. LF rTMS may improve OCD, anxiety, and depressive symptoms in treatment-resistant OCD and was a safe and well-tolerated treatment.
Keywords
Pharmacology (medical), Biological Psychiatry, Psychiatry and Mental health, General Medicine, Obsessive–compulsive disorder, Repetitive transcranial magnetic stimulation, Safety, Efficacy, OBSESSIVE-COMPULSIVE DISORDER, TRANSCRANIAL MAGNETIC STIMULATION, METAANALYSIS, DEPRESSION

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MLA
Tandt, Hannelore, et al. “Is Twice Daily LF-RTMS a Viable Treatment Option for Treatment-Resistant OCD? Results from an Open-Label Feasibility Study.” EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, vol. 271, no. 1, 2021, pp. 211–14, doi:10.1007/s00406-020-01142-x.
APA
Tandt, H., Van de Velde, N., De Witte, S., Audenaert, K., Baeken, C., & Lemmens, G. (2021). Is twice daily LF-rTMS a viable treatment option for treatment-resistant OCD? Results from an open-label feasibility study. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 271(1), 211–214. https://doi.org/10.1007/s00406-020-01142-x
Chicago author-date
Tandt, Hannelore, Nele Van de Velde, Sara De Witte, Kurt Audenaert, Chris Baeken, and Gilbert Lemmens. 2021. “Is Twice Daily LF-RTMS a Viable Treatment Option for Treatment-Resistant OCD? Results from an Open-Label Feasibility Study.” EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 271 (1): 211–14. https://doi.org/10.1007/s00406-020-01142-x.
Chicago author-date (all authors)
Tandt, Hannelore, Nele Van de Velde, Sara De Witte, Kurt Audenaert, Chris Baeken, and Gilbert Lemmens. 2021. “Is Twice Daily LF-RTMS a Viable Treatment Option for Treatment-Resistant OCD? Results from an Open-Label Feasibility Study.” EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 271 (1): 211–214. doi:10.1007/s00406-020-01142-x.
Vancouver
1.
Tandt H, Van de Velde N, De Witte S, Audenaert K, Baeken C, Lemmens G. Is twice daily LF-rTMS a viable treatment option for treatment-resistant OCD? Results from an open-label feasibility study. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 2021;271(1):211–4.
IEEE
[1]
H. Tandt, N. Van de Velde, S. De Witte, K. Audenaert, C. Baeken, and G. Lemmens, “Is twice daily LF-rTMS a viable treatment option for treatment-resistant OCD? Results from an open-label feasibility study,” EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, vol. 271, no. 1, pp. 211–214, 2021.
@article{8664699,
  abstract     = {{Several reports point to the beneficial effects of repetitive transcranial magnetic stimulation (rTMS) in the treatment of resistant obsessive-compulsive disorder (OCD). This study aimed to evaluate the safety and efficacy of rTMS targeting the dmPFC in the treatment of treatment-resistant OCD patients.Twelve patients received 20 sessions of low-frequency (LF) rTMS (1 Hz, 1200 pulses) in a twice daily protocol during 10 weekdays. Y-BOCS and IDS scores modestly but significantly decreased after treatment and at follow-up and HADS anxiety improved at follow-up. LF rTMS may improve OCD, anxiety, and depressive symptoms in treatment-resistant OCD and was a safe and well-tolerated treatment.}},
  author       = {{Tandt, Hannelore and Van de Velde, Nele and De Witte, Sara and Audenaert, Kurt and Baeken, Chris and Lemmens, Gilbert}},
  issn         = {{0940-1334}},
  journal      = {{EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE}},
  keywords     = {{Pharmacology (medical),Biological Psychiatry,Psychiatry and Mental health,General Medicine,Obsessive–compulsive disorder,Repetitive transcranial magnetic stimulation,Safety,Efficacy,OBSESSIVE-COMPULSIVE DISORDER,TRANSCRANIAL MAGNETIC STIMULATION,METAANALYSIS,DEPRESSION}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{211--214}},
  title        = {{Is twice daily LF-rTMS a viable treatment option for treatment-resistant OCD? Results from an open-label feasibility study}},
  url          = {{http://dx.doi.org/10.1007/s00406-020-01142-x}},
  volume       = {{271}},
  year         = {{2021}},
}
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