Advanced search
1 file | 13.82 MB Add to list

Repositioning of the global epicentre of non-optimal cholesterol

Els Clays (UGent) , Gui De Backer (UGent) , Dirk De Bacquer (UGent) , Stefaan De Henauw (UGent) , Delphine De Smedt (UGent) , Patrick Kolsteren (UGent) , Carl Lachat (UGent) , Nathalie Michels (UGent) and Koen Van Herck (UGent)
(2020) NATURE. 582. p.73-77
Author
Organization
Abstract
High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127population-based studies that measured blood lipids in 102.6million individuals aged 18years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7million-4.2million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.

Downloads

  • s41586-020-2338-1.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 13.82 MB

Citation

Please use this url to cite or link to this publication:

MLA
Clays, Els, et al. “Repositioning of the Global Epicentre of Non-Optimal Cholesterol.” NATURE, vol. 582, 2020, pp. 73–77, doi:10.1038/s41586-020-2338-1.
APA
Clays, E., De Backer, G., De Bacquer, D., De Henauw, S., De Smedt, D., Kolsteren, P., … Van Herck, K. (2020). Repositioning of the global epicentre of non-optimal cholesterol. NATURE, 582, 73–77. https://doi.org/10.1038/s41586-020-2338-1
Chicago author-date
Clays, Els, Gui De Backer, Dirk De Bacquer, Stefaan De Henauw, Delphine De Smedt, Patrick Kolsteren, Carl Lachat, Nathalie Michels, and Koen Van Herck. 2020. “Repositioning of the Global Epicentre of Non-Optimal Cholesterol.” NATURE 582: 73–77. https://doi.org/10.1038/s41586-020-2338-1.
Chicago author-date (all authors)
Clays, Els, Gui De Backer, Dirk De Bacquer, Stefaan De Henauw, Delphine De Smedt, Patrick Kolsteren, Carl Lachat, Nathalie Michels, and Koen Van Herck. 2020. “Repositioning of the Global Epicentre of Non-Optimal Cholesterol.” NATURE 582: 73–77. doi:10.1038/s41586-020-2338-1.
Vancouver
1.
Clays E, De Backer G, De Bacquer D, De Henauw S, De Smedt D, Kolsteren P, et al. Repositioning of the global epicentre of non-optimal cholesterol. NATURE. 2020;582:73–7.
IEEE
[1]
E. Clays et al., “Repositioning of the global epicentre of non-optimal cholesterol,” NATURE, vol. 582, pp. 73–77, 2020.
@article{8664471,
  abstract     = {High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127population-based studies that measured blood lipids in 102.6million individuals aged 18years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7million-4.2million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.},
  author       = {Clays, Els and De Backer, Gui and De Bacquer, Dirk and De Henauw, Stefaan and De Smedt, Delphine and Kolsteren, Patrick and Lachat, Carl and Michels, Nathalie and Van Herck, Koen},
  issn         = {0028-0836},
  journal      = {NATURE},
  language     = {eng},
  pages        = {73--77},
  title        = {Repositioning of the global epicentre of non-optimal cholesterol},
  url          = {http://dx.doi.org/10.1038/s41586-020-2338-1},
  volume       = {582},
  year         = {2020},
}

Altmetric
View in Altmetric