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Short-chain fructo-oligosaccharides supplementation to suckling piglets : assessment of pre- and post-weaning performance and gut health

(2020) PLOS ONE. 15(6).
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Abstract
Farmers face difficulties in redeeming their investment in larger litter sizes since this comes with larger litter heterogenicity, lower litter resilience and risk of higher mortality. Dietary oligosaccharides, given to the sow, proved beneficial for the offspring's performance. However, giving oligosaccharides to the suckling piglet is poorly explored. Therefore, this field trial studied the effect of dietary short-chain fructo-oligosaccharides (scFOS; 1g/day; drenched) supplementation to low (LBW, lower quartile), normal (NBW, two intermediate quartiles) and high (HBW, upper quartile) birth weight piglets from birth until 7 or 21 days of age. Performance parameters, gut microbiome and short-chain fatty acids profile of feces and digesta were assessed at birth (d 0), d 7, weaning (d 21.5) and 2 weeks post-weaning (d 36.5). Additional parameters reflecting gut health (intestinal integrity and morphology, mucosal immune system) were analysed at d 36.5. Most parameters changed with age or differed with the piglet's birth weight. Drenching with scFOS increased body weight by 1 kg in NBW suckling piglets and reduced the post-weaning mortality rate by a 100%. No clear difference in the IgG level, the microbiota composition and fermentative activity between the treatment groups was observed. Additionnally, intestinal integrity, determined by measuring intestinal permeability and regenerative capacity, was similar between the treatment groups. Also, intestinal architecture (villus lenght, crypt depth) was not affected by scFOS supplementation. The density of intra-epithelial lymphocytes and the expression profiles (real-time qPCR) for immune system-related genes (IL-10, IL-1ss, IL-6, TNF alpha and IFN gamma) were used to assess mucosal immunity. Only IFN gamma expression, was upregulated in piglets that received scFOS for 7 days. The improved body weight and the reduced post-weaning mortality seen in piglets supplemented with scFOS support the view that scFOS positively impact piglet's health and resilience. However, the modes of action for these effects are not yet fully elucidated and its potential to improve other performance parameters needs further investigation.
Keywords
General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine, INTRAUTERINE GROWTH RESTRICTION, MESSENGER-RNA EXPRESSION, BIRTH-WEIGHT, DIETARY FRUCTOOLIGOSACCHARIDES, BODY-WEIGHT, PIG, MICROBIOTA, MATURATION, IMPACT, CELL

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MLA
Ayuso, Miriam, et al. “Short-Chain Fructo-Oligosaccharides Supplementation to Suckling Piglets : Assessment of Pre- and Post-Weaning Performance and Gut Health.” PLOS ONE, vol. 15, no. 6, 2020, doi:10.1371/journal.pone.0233910.
APA
Ayuso, M., Michiels, J., Wuyts, S., Yan, H., Degroote, J., Lebeer, S., … Van Ginneken, C. (2020). Short-chain fructo-oligosaccharides supplementation to suckling piglets : assessment of pre- and post-weaning performance and gut health. PLOS ONE, 15(6). https://doi.org/10.1371/journal.pone.0233910
Chicago author-date
Ayuso, Miriam, Joris Michiels, Sander Wuyts, Honglin Yan, Jeroen Degroote, Sarah Lebeer, Cindy Le Bourgot, et al. 2020. “Short-Chain Fructo-Oligosaccharides Supplementation to Suckling Piglets : Assessment of Pre- and Post-Weaning Performance and Gut Health.” PLOS ONE 15 (6). https://doi.org/10.1371/journal.pone.0233910.
Chicago author-date (all authors)
Ayuso, Miriam, Joris Michiels, Sander Wuyts, Honglin Yan, Jeroen Degroote, Sarah Lebeer, Cindy Le Bourgot, Emmanuelle Apper, Maryam Majdeddin, Noémie Van Noten, Charlotte Vanden Hole, Steven Van Cruchten, Mario Van Poucke, Luc Peelman, and Chris Van Ginneken. 2020. “Short-Chain Fructo-Oligosaccharides Supplementation to Suckling Piglets : Assessment of Pre- and Post-Weaning Performance and Gut Health.” PLOS ONE 15 (6). doi:10.1371/journal.pone.0233910.
Vancouver
1.
Ayuso M, Michiels J, Wuyts S, Yan H, Degroote J, Lebeer S, et al. Short-chain fructo-oligosaccharides supplementation to suckling piglets : assessment of pre- and post-weaning performance and gut health. PLOS ONE. 2020;15(6).
IEEE
[1]
M. Ayuso et al., “Short-chain fructo-oligosaccharides supplementation to suckling piglets : assessment of pre- and post-weaning performance and gut health,” PLOS ONE, vol. 15, no. 6, 2020.
@article{8664318,
  abstract     = {{Farmers face difficulties in redeeming their investment in larger litter sizes since this comes with larger litter heterogenicity, lower litter resilience and risk of higher mortality. Dietary oligosaccharides, given to the sow, proved beneficial for the offspring's performance. However, giving oligosaccharides to the suckling piglet is poorly explored. Therefore, this field trial studied the effect of dietary short-chain fructo-oligosaccharides (scFOS; 1g/day; drenched) supplementation to low (LBW, lower quartile), normal (NBW, two intermediate quartiles) and high (HBW, upper quartile) birth weight piglets from birth until 7 or 21 days of age. Performance parameters, gut microbiome and short-chain fatty acids profile of feces and digesta were assessed at birth (d 0), d 7, weaning (d 21.5) and 2 weeks post-weaning (d 36.5). Additional parameters reflecting gut health (intestinal integrity and morphology, mucosal immune system) were analysed at d 36.5. Most parameters changed with age or differed with the piglet's birth weight. Drenching with scFOS increased body weight by 1 kg in NBW suckling piglets and reduced the post-weaning mortality rate by a 100%. No clear difference in the IgG level, the microbiota composition and fermentative activity between the treatment groups was observed. Additionnally, intestinal integrity, determined by measuring intestinal permeability and regenerative capacity, was similar between the treatment groups. Also, intestinal architecture (villus lenght, crypt depth) was not affected by scFOS supplementation. The density of intra-epithelial lymphocytes and the expression profiles (real-time qPCR) for immune system-related genes (IL-10, IL-1ss, IL-6, TNF alpha and IFN gamma) were used to assess mucosal immunity. Only IFN gamma expression, was upregulated in piglets that received scFOS for 7 days. The improved body weight and the reduced post-weaning mortality seen in piglets supplemented with scFOS support the view that scFOS positively impact piglet's health and resilience. However, the modes of action for these effects are not yet fully elucidated and its potential to improve other performance parameters needs further investigation.}},
  articleno    = {{e0233910}},
  author       = {{Ayuso, Miriam and Michiels, Joris and Wuyts, Sander and Yan, Honglin and Degroote, Jeroen and Lebeer, Sarah and Le Bourgot, Cindy and Apper, Emmanuelle and Majdeddin, Maryam and Van Noten, Noémie and Vanden Hole, Charlotte and Van Cruchten, Steven and Van Poucke, Mario and Peelman, Luc and Van Ginneken, Chris}},
  issn         = {{1932-6203}},
  journal      = {{PLOS ONE}},
  keywords     = {{General Biochemistry,Genetics and Molecular Biology,General Agricultural and Biological Sciences,General Medicine,INTRAUTERINE GROWTH RESTRICTION,MESSENGER-RNA EXPRESSION,BIRTH-WEIGHT,DIETARY FRUCTOOLIGOSACCHARIDES,BODY-WEIGHT,PIG,MICROBIOTA,MATURATION,IMPACT,CELL}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{28}},
  title        = {{Short-chain fructo-oligosaccharides supplementation to suckling piglets : assessment of pre- and post-weaning performance and gut health}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0233910}},
  volume       = {{15}},
  year         = {{2020}},
}

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