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Equine allogeneic chondrogenic induced mesenchymal stem cells are an effective treatment for degenerative joint disease in horses

(2019) STEM CELLS AND DEVELOPMENT. 28(6). p.410-422
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Abstract
Degenerative joint disease is one of the main causes of equine early retirement from pleasure riding or a performance career. The disease is initially triggered by an abnormal loading of normal cartilage or a normal loading of abnormal cartilage. This primary insult is accompanied with joint inflammation, which leads to further progressive degeneration of the articular cartilage and changes in the surrounding tissues. Therefore, in search for an effective treatment, 75 adult horses with early signs of degenerative fetlock joint disease were enrolled in a randomized, multicenter, double-blinded, and placebo-controlled study. Fifty animals were injected intra-articularly with the investigational veterinary product (IVP) consisting of allogeneic chondrogenic induced mesenchymal stem cells (ciMSCs) with equine allogeneic plasma, and 25 horses were injected with 0.9% NaCl (saline) control product. From week 3 to 18 after treatment, lameness scores (P<0.001), flexion test responses (P<0.034), and joint effusion scores (P<0.001) were remarkably superior in IVP-treated horses. Besides nasal discharge in both treatment groups, no adverse events were observed during the entire study period. On long-term follow-up (1 year), significantly more investigational product-treated horses were working at training level or were returned to their previous level of work (P<0.001).
Keywords
Developmental Biology, Cell Biology, Hematology, allogeneic, MSC, arthrosis, horse, GCP, field trial, PLATELET-RICH PLASMA, CLINICAL-TRIAL, BONE-MARROW, IMMUNOMODULATORY PROPERTIES, INTRAARTICULAR INJECTION, SUBJECTIVE EVALUATION, LAMENESS, OSTEOARTHRITIS, MODEL, REPEATABILITY

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Citation

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MLA
Broeckx, Sarah Y., et al. “Equine Allogeneic Chondrogenic Induced Mesenchymal Stem Cells Are an Effective Treatment for Degenerative Joint Disease in Horses.” STEM CELLS AND DEVELOPMENT, vol. 28, no. 6, 2019, pp. 410–22.
APA
Broeckx, S. Y., Seys, B., Suls, M., Vandenberghe, A., Mariën, T., Adriaensen, E., … Spaas, J. (2019). Equine allogeneic chondrogenic induced mesenchymal stem cells are an effective treatment for degenerative joint disease in horses. STEM CELLS AND DEVELOPMENT, 28(6), 410–422.
Chicago author-date
Broeckx, Sarah Y., Bert Seys, Marc Suls, Aurélie Vandenberghe, Tom Mariën, Edouard Adriaensen, Jeroen Declercq, et al. 2019. “Equine Allogeneic Chondrogenic Induced Mesenchymal Stem Cells Are an Effective Treatment for Degenerative Joint Disease in Horses.” STEM CELLS AND DEVELOPMENT 28 (6): 410–22.
Chicago author-date (all authors)
Broeckx, Sarah Y., Bert Seys, Marc Suls, Aurélie Vandenberghe, Tom Mariën, Edouard Adriaensen, Jeroen Declercq, Lore Van Hecke, Gabriele Braun, Klaus Hellmann, and Jan Spaas. 2019. “Equine Allogeneic Chondrogenic Induced Mesenchymal Stem Cells Are an Effective Treatment for Degenerative Joint Disease in Horses.” STEM CELLS AND DEVELOPMENT 28 (6): 410–422.
Vancouver
1.
Broeckx SY, Seys B, Suls M, Vandenberghe A, Mariën T, Adriaensen E, et al. Equine allogeneic chondrogenic induced mesenchymal stem cells are an effective treatment for degenerative joint disease in horses. STEM CELLS AND DEVELOPMENT. 2019;28(6):410–22.
IEEE
[1]
S. Y. Broeckx et al., “Equine allogeneic chondrogenic induced mesenchymal stem cells are an effective treatment for degenerative joint disease in horses,” STEM CELLS AND DEVELOPMENT, vol. 28, no. 6, pp. 410–422, 2019.
@article{8663998,
  abstract     = {Degenerative joint disease is one of the main causes of equine early retirement from pleasure riding or a performance career. The disease is initially triggered by an abnormal loading of normal cartilage or a normal loading of abnormal cartilage. This primary insult is accompanied with joint inflammation, which leads to further progressive degeneration of the articular cartilage and changes in the surrounding tissues. Therefore, in search for an effective treatment, 75 adult horses with early signs of degenerative fetlock joint disease were enrolled in a randomized, multicenter, double-blinded, and placebo-controlled study. Fifty animals were injected intra-articularly with the investigational veterinary product (IVP) consisting of allogeneic chondrogenic induced mesenchymal stem cells (ciMSCs) with equine allogeneic plasma, and 25 horses were injected with 0.9% NaCl (saline) control product. From week 3 to 18 after treatment, lameness scores (P<0.001), flexion test responses (P<0.034), and joint effusion scores (P<0.001) were remarkably superior in IVP-treated horses. Besides nasal discharge in both treatment groups, no adverse events were observed during the entire study period. On long-term follow-up (1 year), significantly more investigational product-treated horses were working at training level or were returned to their previous level of work (P<0.001).},
  author       = {Broeckx, Sarah Y. and Seys, Bert and Suls, Marc and Vandenberghe, Aurélie and Mariën, Tom and Adriaensen, Edouard and Declercq, Jeroen and Van Hecke, Lore and Braun, Gabriele and Hellmann, Klaus and Spaas, Jan},
  issn         = {1547-3287},
  journal      = {STEM CELLS AND DEVELOPMENT},
  keywords     = {Developmental Biology,Cell Biology,Hematology,allogeneic,MSC,arthrosis,horse,GCP,field trial,PLATELET-RICH PLASMA,CLINICAL-TRIAL,BONE-MARROW,IMMUNOMODULATORY PROPERTIES,INTRAARTICULAR INJECTION,SUBJECTIVE EVALUATION,LAMENESS,OSTEOARTHRITIS,MODEL,REPEATABILITY},
  language     = {eng},
  number       = {6},
  pages        = {410--422},
  title        = {Equine allogeneic chondrogenic induced mesenchymal stem cells are an effective treatment for degenerative joint disease in horses},
  url          = {http://dx.doi.org/10.1089/scd.2018.0061},
  volume       = {28},
  year         = {2019},
}

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