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The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network’s first protocol: deep phenotyping in three sub-Saharan African countries

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Abstract
Background:The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network is a new andbroadly-based group of research scientists and health advocates based in the UK, Africa and North America.Methods:This paper describes the protocol that underpins the clinical research activity of the Network, so that theinvestigators, and broader global health community, can have access to‘deep phenotyping’(social determinants ofhealth, demographic and clinical parameters, placental biology and agnostic discovery biology) of women as theyadvance through pregnancy to the end of the puerperium, whether those pregnancies have normal outcomes orare complicated by one/more of the placental disorders of pregnancy (pregnancy hypertension, fetal growthrestriction and stillbirth). Our clinical sites are in The Gambia (Farafenni), Kenya (Kilifi County), and Mozambique(Maputo Province). In each country, 50 non-pregnant women of reproductive age will be recruited each month for1 year, to provide a final national sample size of 600; these women will provide culturally-, ethnically-, seasonally-and spatially-relevant control data with which to compare women with normal and complicated pregnancies.Between the three countries we will recruit≈10,000 unselected pregnant women over 2 years. An estimated 1500women will experience one/more placental complications over the same epoch. Importantly, as we will haveaccurate gestational age dating using the TraCer device, we will be able to discriminate between fetal growthrestriction and preterm birth. Recruitment and follow-up will be primarily facility-based and will include womenbooking for antenatal care, subsequent visits in the third trimester, at time-of-disease, when relevant, during/immediately after birth and 6 weeks after birth. Conclusions:To accelerate progress towards the women’s and children’s health-relevant Sustainable DevelopmentGoals, we need to understand how a variety of social, chronic disease, biomarker and pregnancy-specificdeterminants health interact to result in either a resilient or a compromised pregnancy for either mother or fetus/newborn, or both. This protocol has been designed to create such a depth of understanding. We are seekingfunding to maintain the cohort to better understand the implications of pregnancy complications for bothmaternal and child health.Keywords:Pregnancy, Africa south of the Sahara, Biorepository, Pre-eclampsia, Biological specimens
Keywords
Obstetrics and Gynaecology, Reproductive Medicine, Pregnancy, Africa south of the Sahara, Biorepository, Pre-eclampsia, Biological specimens

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MLA
von Dadelszen, Peter, et al. “The PRECISE (PREgnancy Care Integrating Translational Science, Everywhere) Network’s First Protocol: Deep Phenotyping in Three Sub-Saharan African Countries.” Reproductive Health, 2020.
APA
von Dadelszen, P., the PRECISE Network, [missing], Flint-O’Kane, M., Poston, L., Craik, R., Russell, D., … Magee, L. A. (2020). The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network’s first protocol: deep phenotyping in three sub-Saharan African countries. Reproductive Health.
Chicago author-date
Dadelszen, Peter von, [missing] the PRECISE Network, Meriel Flint-O’Kane, Lucilla Poston, Rachel Craik, Donna Russell, Rachel M. Tribe, et al. 2020. “The PRECISE (PREgnancy Care Integrating Translational Science, Everywhere) Network’s First Protocol: Deep Phenotyping in Three Sub-Saharan African Countries.” Reproductive Health.
Chicago author-date (all authors)
von Dadelszen, Peter, [missing] the PRECISE Network, Meriel Flint-O’Kane, Lucilla Poston, Rachel Craik, Donna Russell, Rachel M. Tribe, Umberto d’Alessandro, Anna Roca, Hawanatu Jah, Marleen Temmerman, Angela Koech Etyang, Esperança Sevene, Paulo Chin, Joy E. Lawn, Hannah Blencowe, Jane Sandall, Tatiana T. Salisbury, Benjamin Barratt, Andrew H. Shennan, Prestige Tatenda Makanga, and Laura A. Magee. 2020. “The PRECISE (PREgnancy Care Integrating Translational Science, Everywhere) Network’s First Protocol: Deep Phenotyping in Three Sub-Saharan African Countries.” Reproductive Health.
Vancouver
1.
von Dadelszen P, the PRECISE Network [missing], Flint-O’Kane M, Poston L, Craik R, Russell D, et al. The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network’s first protocol: deep phenotyping in three sub-Saharan African countries. Reproductive Health. 2020;
IEEE
[1]
P. von Dadelszen et al., “The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network’s first protocol: deep phenotyping in three sub-Saharan African countries,” Reproductive Health, 2020.
@article{8663221,
  abstract     = {Background:The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network is a new andbroadly-based group of research scientists and health advocates based in the UK, Africa and North America.Methods:This paper describes the protocol that underpins the clinical research activity of the Network, so that theinvestigators, and broader global health community, can have access to‘deep phenotyping’(social determinants ofhealth, demographic and clinical parameters, placental biology and agnostic discovery biology) of women as theyadvance through pregnancy to the end of the puerperium, whether those pregnancies have normal outcomes orare complicated by one/more of the placental disorders of pregnancy (pregnancy hypertension, fetal growthrestriction and stillbirth). Our clinical sites are in The Gambia (Farafenni), Kenya (Kilifi County), and Mozambique(Maputo Province). In each country, 50 non-pregnant women of reproductive age will be recruited each month for1 year, to provide a final national sample size of 600; these women will provide culturally-, ethnically-, seasonally-and spatially-relevant control data with which to compare women with normal and complicated pregnancies.Between the three countries we will recruit≈10,000 unselected pregnant women over 2 years. An estimated 1500women will experience one/more placental complications over the same epoch. Importantly, as we will haveaccurate gestational age dating using the TraCer device, we will be able to discriminate between fetal growthrestriction and preterm birth. Recruitment and follow-up will be primarily facility-based and will include womenbooking for antenatal care, subsequent visits in the third trimester, at time-of-disease, when relevant, during/immediately after birth and 6 weeks after birth.
Conclusions:To accelerate progress towards the women’s and children’s health-relevant Sustainable DevelopmentGoals, we need to understand how a variety of social, chronic disease, biomarker and pregnancy-specificdeterminants health interact to result in either a resilient or a compromised pregnancy for either mother or fetus/newborn, or both. This protocol has been designed to create such a depth of understanding. We are seekingfunding to maintain the cohort to better understand the implications of pregnancy complications for bothmaternal and child health.Keywords:Pregnancy, Africa south of the Sahara, Biorepository, Pre-eclampsia, Biological specimens},
  author       = {von Dadelszen, Peter and the PRECISE Network, [missing] and Flint-O’Kane, Meriel and Poston, Lucilla and Craik, Rachel and Russell, Donna and Tribe, Rachel M. and d’Alessandro, Umberto and Roca, Anna and Jah, Hawanatu and Temmerman, Marleen and Koech Etyang, Angela and Sevene, Esperança and Chin, Paulo and Lawn, Joy E. and Blencowe, Hannah and Sandall, Jane and Salisbury, Tatiana T. and Barratt, Benjamin and Shennan, Andrew H. and Makanga, Prestige Tatenda and Magee, Laura A.},
  issn         = {1742-4755},
  journal      = {Reproductive Health},
  keywords     = {Obstetrics and Gynaecology,Reproductive Medicine,Pregnancy,Africa south of the Sahara,Biorepository,Pre-eclampsia,Biological specimens},
  language     = {eng},
  title        = {The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network’s first protocol: deep phenotyping in three sub-Saharan African countries},
  url          = {http://dx.doi.org/10.1186/s12978-020-0872-9},
  year         = {2020},
}

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