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Müller cells as a target for retinal therapy

Joke Devoldere (UGent) , Karen Peynshaert (UGent) , Stefaan De Smedt (UGent) and Katrien Remaut (UGent)
(2019) DRUG DISCOVERY TODAY. 24(8). p.1483-1498
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Abstract
Muller cells are specialized glial cells that span the entire retina from the vitreous cavity to the subretinal space. Their functional diversity and unique radial morphology render them particularly interesting targets for new therapeutic approaches. In this review, we reflect on various possibilities for selective Willer cell targeting and describe how some of their cellular mechanisms can be used for retinal neuroprotection. Intriguingly, cross-species investigation of their properties has revealed that Muller cells also have an essential role in retinal regeneration. Although many questions regarding this subject remain, it is clear that Muller cells have unique characteristics that make them suitable targets for the prevention and treatment of numerous retinal diseases.
Keywords
Pharmacology, Drug Discovery, EPITHELIUM-DERIVED FACTOR, CILIARY NEUROTROPHIC FACTOR, FIBRILLARY ACIDIC PROTEIN, INTRAOCULAR GENE-TRANSFER, GLIAL-CELLS, GANGLION-CELLS, OPTIC-NERVE, IN-VIVO, ADENOASSOCIATED VIRUS, GROWTH-FACTOR

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MLA
Devoldere, Joke, et al. “Müller Cells as a Target for Retinal Therapy.” DRUG DISCOVERY TODAY, vol. 24, no. 8, 2019, pp. 1483–98, doi:10.1016/j.drudis.2019.01.023.
APA
Devoldere, J., Peynshaert, K., De Smedt, S., & Remaut, K. (2019). Müller cells as a target for retinal therapy. DRUG DISCOVERY TODAY, 24(8), 1483–1498. https://doi.org/10.1016/j.drudis.2019.01.023
Chicago author-date
Devoldere, Joke, Karen Peynshaert, Stefaan De Smedt, and Katrien Remaut. 2019. “Müller Cells as a Target for Retinal Therapy.” DRUG DISCOVERY TODAY 24 (8): 1483–98. https://doi.org/10.1016/j.drudis.2019.01.023.
Chicago author-date (all authors)
Devoldere, Joke, Karen Peynshaert, Stefaan De Smedt, and Katrien Remaut. 2019. “Müller Cells as a Target for Retinal Therapy.” DRUG DISCOVERY TODAY 24 (8): 1483–1498. doi:10.1016/j.drudis.2019.01.023.
Vancouver
1.
Devoldere J, Peynshaert K, De Smedt S, Remaut K. Müller cells as a target for retinal therapy. DRUG DISCOVERY TODAY. 2019;24(8):1483–98.
IEEE
[1]
J. Devoldere, K. Peynshaert, S. De Smedt, and K. Remaut, “Müller cells as a target for retinal therapy,” DRUG DISCOVERY TODAY, vol. 24, no. 8, pp. 1483–1498, 2019.
@article{8663055,
  abstract     = {{Muller cells are specialized glial cells that span the entire retina from the vitreous cavity to the subretinal space. Their functional diversity and unique radial morphology render them particularly interesting targets for new therapeutic approaches. In this review, we reflect on various possibilities for selective Willer cell targeting and describe how some of their cellular mechanisms can be used for retinal neuroprotection. Intriguingly, cross-species investigation of their properties has revealed that Muller cells also have an essential role in retinal regeneration. Although many questions regarding this subject remain, it is clear that Muller cells have unique characteristics that make them suitable targets for the prevention and treatment of numerous retinal diseases.}},
  author       = {{Devoldere, Joke and Peynshaert, Karen and De Smedt, Stefaan and Remaut, Katrien}},
  issn         = {{1359-6446}},
  journal      = {{DRUG DISCOVERY TODAY}},
  keywords     = {{Pharmacology,Drug Discovery,EPITHELIUM-DERIVED FACTOR,CILIARY NEUROTROPHIC FACTOR,FIBRILLARY ACIDIC PROTEIN,INTRAOCULAR GENE-TRANSFER,GLIAL-CELLS,GANGLION-CELLS,OPTIC-NERVE,IN-VIVO,ADENOASSOCIATED VIRUS,GROWTH-FACTOR}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1483--1498}},
  title        = {{Müller cells as a target for retinal therapy}},
  url          = {{http://dx.doi.org/10.1016/j.drudis.2019.01.023}},
  volume       = {{24}},
  year         = {{2019}},
}

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