Morphology and composition of the inner limiting membrane : species-specific variations and relevance toward drug delivery research
- Author
- Karen Peynshaert (UGent) , Joke Devoldere (UGent) , An-Katrien Minnaert, Stefaan De Smedt (UGent) and Katrien Remaut (UGent)
- Organization
- Project
- Abstract
- The inner limiting membrane (ILM) represents the structural boundary between the vitreous and the retina, and is suggested to act as a barrier for a wide range of retinal therapies. While it is widely acknowledged that the morphology of the human ILM exhibits regional variations and undergoes age-related changes, insight into its structure in laboratory animals is very limited. Besides presenting a detailed overview of the morphology and composition of the human ILM, this review specifically reflects on the species-specific differences in ILM structure. With these differences in mind, we furthermore summarize the most relevant reports on the barrier role of the ILM with regard to viral vectors, nanoparticles, anti-VEGF medication and stem cells. Overall, this review aims to deliberate on the impact of species-specific ILM variations on drug delivery research as well as to pinpoint knowledge gaps which future basic research should resolve.
- Keywords
- Inner limiting membrane, nanoparticles, species variations, viral vector, vitreoretinal interface, HEPARAN-SULFATE PROTEOGLYCAN, TISSUE-PLASMINOGEN ACTIVATOR, FULL-THICKNESS RETINA, BASEMENT-MEMBRANE, INTRAVITREAL INJECTION, GENE DELIVERY, TRANSFECTION EFFICIENCY, VITREORETINAL JUNCTURE, ALBUMIN NANOPARTICLES, VECTOR TRANSDUCTION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8663040
- MLA
- Peynshaert, Karen, et al. “Morphology and Composition of the Inner Limiting Membrane : Species-Specific Variations and Relevance toward Drug Delivery Research.” CURRENT EYE RESEARCH, vol. 44, no. 5, 2019, pp. 465–75, doi:10.1080/02713683.2019.1565890.
- APA
- Peynshaert, K., Devoldere, J., Minnaert, A.-K., De Smedt, S., & Remaut, K. (2019). Morphology and composition of the inner limiting membrane : species-specific variations and relevance toward drug delivery research. CURRENT EYE RESEARCH, 44(5), 465–475. https://doi.org/10.1080/02713683.2019.1565890
- Chicago author-date
- Peynshaert, Karen, Joke Devoldere, An-Katrien Minnaert, Stefaan De Smedt, and Katrien Remaut. 2019. “Morphology and Composition of the Inner Limiting Membrane : Species-Specific Variations and Relevance toward Drug Delivery Research.” CURRENT EYE RESEARCH 44 (5): 465–75. https://doi.org/10.1080/02713683.2019.1565890.
- Chicago author-date (all authors)
- Peynshaert, Karen, Joke Devoldere, An-Katrien Minnaert, Stefaan De Smedt, and Katrien Remaut. 2019. “Morphology and Composition of the Inner Limiting Membrane : Species-Specific Variations and Relevance toward Drug Delivery Research.” CURRENT EYE RESEARCH 44 (5): 465–475. doi:10.1080/02713683.2019.1565890.
- Vancouver
- 1.Peynshaert K, Devoldere J, Minnaert A-K, De Smedt S, Remaut K. Morphology and composition of the inner limiting membrane : species-specific variations and relevance toward drug delivery research. CURRENT EYE RESEARCH. 2019;44(5):465–75.
- IEEE
- [1]K. Peynshaert, J. Devoldere, A.-K. Minnaert, S. De Smedt, and K. Remaut, “Morphology and composition of the inner limiting membrane : species-specific variations and relevance toward drug delivery research,” CURRENT EYE RESEARCH, vol. 44, no. 5, pp. 465–475, 2019.
@article{8663040,
abstract = {{The inner limiting membrane (ILM) represents the structural boundary between the vitreous and the retina, and is suggested to act as a barrier for a wide range of retinal therapies. While it is widely acknowledged that the morphology of the human ILM exhibits regional variations and undergoes age-related changes, insight into its structure in laboratory animals is very limited. Besides presenting a detailed overview of the morphology and composition of the human ILM, this review specifically reflects on the species-specific differences in ILM structure. With these differences in mind, we furthermore summarize the most relevant reports on the barrier role of the ILM with regard to viral vectors, nanoparticles, anti-VEGF medication and stem cells. Overall, this review aims to deliberate on the impact of species-specific ILM variations on drug delivery research as well as to pinpoint knowledge gaps which future basic research should resolve.}},
author = {{Peynshaert, Karen and Devoldere, Joke and Minnaert, An-Katrien and De Smedt, Stefaan and Remaut, Katrien}},
issn = {{0271-3683}},
journal = {{CURRENT EYE RESEARCH}},
keywords = {{Inner limiting membrane,nanoparticles,species variations,viral vector,vitreoretinal interface,HEPARAN-SULFATE PROTEOGLYCAN,TISSUE-PLASMINOGEN ACTIVATOR,FULL-THICKNESS RETINA,BASEMENT-MEMBRANE,INTRAVITREAL INJECTION,GENE DELIVERY,TRANSFECTION EFFICIENCY,VITREORETINAL JUNCTURE,ALBUMIN NANOPARTICLES,VECTOR TRANSDUCTION}},
language = {{eng}},
number = {{5}},
pages = {{465--475}},
title = {{Morphology and composition of the inner limiting membrane : species-specific variations and relevance toward drug delivery research}},
url = {{http://doi.org/10.1080/02713683.2019.1565890}},
volume = {{44}},
year = {{2019}},
}
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