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Mycotoxin exposure and human cancer risk: A systematic review of epidemiological studies

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Abstract
In recent years, there has been an increasing interest in investigating the carcinogenicity of mycotoxins in humans. This systematic review aims to provide an overview of data linking exposure to different mycotoxins with human cancer risk. Publications (2019 and earlier) of case–control or longitudinal cohort studies were identified in PubMed and EMBASE. These articles were then screened by independent reviewers and their quality was assessed according to the Newcastle–Ottawa scale. Animal, cross‐sectional, and molecular studies satisfied criteria for exclusion. In total, 14 articles were included: 13 case–control studies and 1 longitudinal cohort study. Included articles focused on associations of mycotoxin exposure with primary liver, breast, and cervical cancer. Overall, a positive association between the consumption of aflatoxin‐contaminated foods and primary liver cancer risk was verified. Two case–control studies in Africa investigated the relationship between zearalenone and its metabolites and breast cancer risk, though conflicting results were reported. Two case–control studies investigated the association between hepatocellular carcinoma and fumonisin B1 exposure, but no significant associations were observed. This systematic review incorporates several clear observations of dose‐dependent associations between aflatoxins and liver cancer risk, in keeping with IARC Monograph conclusions. Only few human epidemiological studies investigated the associations between mycotoxin exposures and cancer risk. To close this gap, more in‐depth research is needed to unravel evidence for other common mycotoxins, such as deoxynivalenol and ochratoxin A. The link between mycotoxin exposures and cancer risk has mainly been established in experimental studies, and needs to be confirmed in human epidemiological studies to support the evidence‐based public health strategies.
Keywords
Food Science

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MLA
Claeys, Liesel, et al. “Mycotoxin Exposure and Human Cancer Risk: A Systematic Review of Epidemiological Studies.” Comprehensive Reviews in Food Science and Food Safety, Wiley-Blackwell, 2020.
APA
Claeys, L., Romano, C., De Ruyck, K., Wilson, H., Fervers, B., Korenjak, M., … Huybrechts, I. (2020). Mycotoxin exposure and human cancer risk: A systematic review of epidemiological studies. Comprehensive Reviews in Food Science and Food Safety.
Chicago author-date
Claeys, Liesel, Chiara Romano, Karl De Ruyck, Hayley Wilson, Beatrice Fervers, Michael Korenjak, Jiri Zavadil, et al. 2020. “Mycotoxin Exposure and Human Cancer Risk: A Systematic Review of Epidemiological Studies.” Comprehensive Reviews in Food Science and Food Safety.
Chicago author-date (all authors)
Claeys, Liesel, Chiara Romano, Karl De Ruyck, Hayley Wilson, Beatrice Fervers, Michael Korenjak, Jiri Zavadil, Marc J. Gunter, Sarah De Saeger, Marthe De Boevre, and Inge Huybrechts. 2020. “Mycotoxin Exposure and Human Cancer Risk: A Systematic Review of Epidemiological Studies.” Comprehensive Reviews in Food Science and Food Safety.
Vancouver
1.
Claeys L, Romano C, De Ruyck K, Wilson H, Fervers B, Korenjak M, et al. Mycotoxin exposure and human cancer risk: A systematic review of epidemiological studies. Comprehensive Reviews in Food Science and Food Safety. 2020;
IEEE
[1]
L. Claeys et al., “Mycotoxin exposure and human cancer risk: A systematic review of epidemiological studies,” Comprehensive Reviews in Food Science and Food Safety, 2020.
@article{8662824,
  abstract     = {In recent years, there has been an increasing interest in investigating the carcinogenicity of mycotoxins in humans. This systematic review aims to provide an overview of data linking exposure to different mycotoxins with human cancer risk. Publications (2019 and earlier) of case–control or longitudinal cohort studies were identified in PubMed and EMBASE. These articles were then screened by independent reviewers and their quality was assessed according to the Newcastle–Ottawa scale. Animal, cross‐sectional, and molecular studies satisfied criteria for exclusion. In total, 14 articles were included: 13 case–control studies and 1 longitudinal cohort study. Included articles focused on associations of mycotoxin exposure with primary liver, breast, and cervical cancer. Overall, a positive association between the consumption of aflatoxin‐contaminated foods and primary liver cancer risk was verified. Two case–control studies in Africa investigated the relationship between zearalenone and its metabolites and breast cancer risk, though conflicting results were reported. Two case–control studies investigated the association between hepatocellular carcinoma and fumonisin B1 exposure, but no significant associations were observed. This systematic review incorporates several clear observations of dose‐dependent associations between aflatoxins and liver cancer risk, in keeping with IARC Monograph conclusions. Only few human epidemiological studies investigated the associations between mycotoxin exposures and cancer risk. To close this gap, more in‐depth research is needed to unravel evidence for other common mycotoxins, such as deoxynivalenol and ochratoxin A. The link between mycotoxin exposures and cancer risk has mainly been established in experimental studies, and needs to be confirmed in human epidemiological studies to support the evidence‐based public health strategies.},
  author       = {Claeys, Liesel and Romano, Chiara and De Ruyck, Karl and Wilson, Hayley and Fervers, Beatrice and Korenjak, Michael and Zavadil, Jiri and Gunter, Marc J. and De Saeger, Sarah and De Boevre, Marthe and Huybrechts, Inge},
  issn         = {1541-4337},
  journal      = {Comprehensive Reviews in Food Science and Food Safety},
  keywords     = {Food Science},
  language     = {eng},
  publisher    = {Wiley-Blackwell},
  title        = {Mycotoxin exposure and human cancer risk: A systematic review of epidemiological studies},
  url          = {http://dx.doi.org/10.1111/1541-4337.12567},
  year         = {2020},
}

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