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Transcriptional regulation of DC fate specification

Cedric Bosteels (UGent) and Charlotte Scott (UGent)
(2020) MOLECULAR IMMUNOLOGY. 121. p.38-46
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Abstract
Dendritic cells function in the immune system to instruct adaptive immune cells to respond accordingly to different threats. While conventional dendritic cells can be subdivided into two main subtypes, termed cDC1s and cDC2s, it is clear that further heterogeneity exists within these subtypes, particularly for cDC2s. Understanding the signals involved in specifying each of these lineages and subtypes thereof is crucial to (i) enable us to determine their specific functions and (ii) put us in a position to be able to target these cells to promote or prevent a specific function in any given disease setting. Although we still have much to learn regarding the specification of these cells, here we review the most recent advances in our understanding of this and highlight some of the next questions for the future.
Keywords
Immunology, Molecular Biology, Dendritic cells, Transcription Factors, DC fate, Irf4, Irf8, Zeb1, Zeb2, Notch, Tbet, Klf4, MHC CLASS-II, DENDRITIC-CELL-DEVELOPMENT, LYMPHOTOXIN-BETA-RECEPTOR, T-CELLS, SIGNALING CONTROLS, FACTOR E2-2, IFN-GAMMA, IRF8, DIFFERENTIATION, EXPRESSION

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Citation

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MLA
Bosteels, Cedric, and Charlotte Scott. “Transcriptional Regulation of DC Fate Specification.” MOLECULAR IMMUNOLOGY, vol. 121, 2020, pp. 38–46, doi:10.1016/j.molimm.2020.02.021.
APA
Bosteels, C., & Scott, C. (2020). Transcriptional regulation of DC fate specification. MOLECULAR IMMUNOLOGY, 121, 38–46. https://doi.org/10.1016/j.molimm.2020.02.021
Chicago author-date
Bosteels, Cedric, and Charlotte Scott. 2020. “Transcriptional Regulation of DC Fate Specification.” MOLECULAR IMMUNOLOGY 121: 38–46. https://doi.org/10.1016/j.molimm.2020.02.021.
Chicago author-date (all authors)
Bosteels, Cedric, and Charlotte Scott. 2020. “Transcriptional Regulation of DC Fate Specification.” MOLECULAR IMMUNOLOGY 121: 38–46. doi:10.1016/j.molimm.2020.02.021.
Vancouver
1.
Bosteels C, Scott C. Transcriptional regulation of DC fate specification. MOLECULAR IMMUNOLOGY. 2020;121:38–46.
IEEE
[1]
C. Bosteels and C. Scott, “Transcriptional regulation of DC fate specification,” MOLECULAR IMMUNOLOGY, vol. 121, pp. 38–46, 2020.
@article{8662391,
  abstract     = {{Dendritic cells function in the immune system to instruct adaptive immune cells to respond accordingly to different threats. While conventional dendritic cells can be subdivided into two main subtypes, termed cDC1s and cDC2s, it is clear that further heterogeneity exists within these subtypes, particularly for cDC2s. Understanding the signals involved in specifying each of these lineages and subtypes thereof is crucial to (i) enable us to determine their specific functions and (ii) put us in a position to be able to target these cells to promote or prevent a specific function in any given disease setting. Although we still have much to learn regarding the specification of these cells, here we review the most recent advances in our understanding of this and highlight some of the next questions for the future.}},
  author       = {{Bosteels, Cedric and Scott, Charlotte}},
  issn         = {{0161-5890}},
  journal      = {{MOLECULAR IMMUNOLOGY}},
  keywords     = {{Immunology,Molecular Biology,Dendritic cells,Transcription Factors,DC fate,Irf4,Irf8,Zeb1,Zeb2,Notch,Tbet,Klf4,MHC CLASS-II,DENDRITIC-CELL-DEVELOPMENT,LYMPHOTOXIN-BETA-RECEPTOR,T-CELLS,SIGNALING CONTROLS,FACTOR E2-2,IFN-GAMMA,IRF8,DIFFERENTIATION,EXPRESSION}},
  language     = {{eng}},
  pages        = {{38--46}},
  title        = {{Transcriptional regulation of DC fate specification}},
  url          = {{http://dx.doi.org/10.1016/j.molimm.2020.02.021}},
  volume       = {{121}},
  year         = {{2020}},
}

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