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Exploration of isoxanthohumol bioconversion from spent hops into 8-prenylnaringenin using resting cells of Eubacterium limosum

Esther Moens (UGent) , Selin Bolca, Tom Van de Wiele (UGent) , Anita Van Landschoot (UGent) , Jan Goeman (UGent) , Sam Possemiers (UGent) and Willy Verstraete (UGent)
(2020) AMB EXPRESS. 10(1).
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Abstract
Hops is an almost unique source of the potent phytoestrogen 8-prenylnaringenin (8-PN). As hops contain only low levels of 8-PN, synthesis may be more attractive than extraction. A strain of the Gram-positive Eubacterium limosum was isolated previously for 8-PN production from more abundant precursor isoxanthohumol (IX) from hops. In this study, spent hops, an industrial side stream from the beer industry, was identified as interesting source of IX. Yet, hop-derived compounds are well-known antibacterial agents and the traces of a large variety of different compounds in spent hops interfered with growth and IX conversion. Critical factors to finally enable bacterial 8-PN production from spent hops, using a food and feed grade medium, were evaluated in this research. The use of bacterial resting cells and complex medium at a pH of 7.8-8 best fulfilled the requirements for 8-PN production and generated a solid basis for development of an economic process.
Keywords
Eubacterium limosum, Hop fermentation, Antibacterial, Isoxanthohumol, 8-prenylnaringenin, Industrial fermentation, HUMULUS-LUPULUS L., METHYLOTROPHIC GROWTH, ACETOBACTERIUM-WOODII, ACETOGENIC BACTERIA, ENERGY-CONSERVATION, ESSENTIAL OILS, O-DEMETHYLASE, XANTHOHUMOL, BEER, METABOLISM

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MLA
Moens, Esther, et al. “Exploration of Isoxanthohumol Bioconversion from Spent Hops into 8-Prenylnaringenin Using Resting Cells of Eubacterium Limosum.” AMB EXPRESS, vol. 10, no. 1, 2020.
APA
Moens, E., Bolca, S., Van de Wiele, T., Van Landschoot, A., Goeman, J., Possemiers, S., & Verstraete, W. (2020). Exploration of isoxanthohumol bioconversion from spent hops into 8-prenylnaringenin using resting cells of Eubacterium limosum. AMB EXPRESS, 10(1).
Chicago author-date
Moens, Esther, Selin Bolca, Tom Van de Wiele, Anita Van Landschoot, Jan Goeman, Sam Possemiers, and Willy Verstraete. 2020. “Exploration of Isoxanthohumol Bioconversion from Spent Hops into 8-Prenylnaringenin Using Resting Cells of Eubacterium Limosum.” AMB EXPRESS 10 (1).
Chicago author-date (all authors)
Moens, Esther, Selin Bolca, Tom Van de Wiele, Anita Van Landschoot, Jan Goeman, Sam Possemiers, and Willy Verstraete. 2020. “Exploration of Isoxanthohumol Bioconversion from Spent Hops into 8-Prenylnaringenin Using Resting Cells of Eubacterium Limosum.” AMB EXPRESS 10 (1).
Vancouver
1.
Moens E, Bolca S, Van de Wiele T, Van Landschoot A, Goeman J, Possemiers S, et al. Exploration of isoxanthohumol bioconversion from spent hops into 8-prenylnaringenin using resting cells of Eubacterium limosum. AMB EXPRESS. 2020;10(1).
IEEE
[1]
E. Moens et al., “Exploration of isoxanthohumol bioconversion from spent hops into 8-prenylnaringenin using resting cells of Eubacterium limosum,” AMB EXPRESS, vol. 10, no. 1, 2020.
@article{8662043,
  abstract     = {Hops is an almost unique source of the potent phytoestrogen 8-prenylnaringenin (8-PN). As hops contain only low levels of 8-PN, synthesis may be more attractive than extraction. A strain of the Gram-positive Eubacterium limosum was isolated previously for 8-PN production from more abundant precursor isoxanthohumol (IX) from hops. In this study, spent hops, an industrial side stream from the beer industry, was identified as interesting source of IX. Yet, hop-derived compounds are well-known antibacterial agents and the traces of a large variety of different compounds in spent hops interfered with growth and IX conversion. Critical factors to finally enable bacterial 8-PN production from spent hops, using a food and feed grade medium, were evaluated in this research. The use of bacterial resting cells and complex medium at a pH of 7.8-8 best fulfilled the requirements for 8-PN production and generated a solid basis for development of an economic process.},
  articleno    = {79},
  author       = {Moens, Esther and Bolca, Selin and Van de Wiele, Tom and Van Landschoot, Anita and Goeman, Jan and Possemiers, Sam and Verstraete, Willy},
  issn         = {2191-0855},
  journal      = {AMB EXPRESS},
  keywords     = {Eubacterium limosum,Hop fermentation,Antibacterial,Isoxanthohumol,8-prenylnaringenin,Industrial fermentation,HUMULUS-LUPULUS L.,METHYLOTROPHIC GROWTH,ACETOBACTERIUM-WOODII,ACETOGENIC BACTERIA,ENERGY-CONSERVATION,ESSENTIAL OILS,O-DEMETHYLASE,XANTHOHUMOL,BEER,METABOLISM},
  language     = {eng},
  number       = {1},
  pages        = {11},
  title        = {Exploration of isoxanthohumol bioconversion from spent hops into 8-prenylnaringenin using resting cells of Eubacterium limosum},
  url          = {http://dx.doi.org/10.1186/s13568-020-01015-5},
  volume       = {10},
  year         = {2020},
}

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