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Comprehensive toxicokinetic analysis reveals major interspecies differences in absorption, distribution and elimination of citrinin in pigs and broiler chickens

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Abstract
A comprehensive toxicokinetic analysis of citrinin (CIT) revealed interspecies differences for all toxicokinetic parameters and in absolute oral bioavailability. Oral bioavailability for CIT was complete for broilers (113-131%), while ranging from 37 to 44% in pigs. CIT was more rapidly absorbed in pigs (T-max = 0.92 h) compared to broiler chickens (T-max = 7.33 h). The elimination of CIT was slower in pigs (T-1/2el = 26.81 h after intravenous (IV) administration) compared to chickens (T-1/2el = 1.97 h after IV administration), due to the striking difference in clearance (Cl-iv =9.87 mL/h/kg for pigs versus Cl-iv = 863.09 mL/h/kg for broilers). Also, the volume of distribution differed significantly between pigs (Vd = 0.30 L/kg after IV administration) and chickens (Vd = 2.46 L/kg after IV administration). However, plasma protein binding did not differ statistically significant (91-98%). It is imperative to further investigate biotransformation and elimination pathways in different species, including humans.
Keywords
Toxicology, Food Science, General Medicine, OCHRATOXIN-A, METABOLITE DIHYDROCITRINONE, MYCOTOXIN CITRININ, NEPHROTOXICITY, ZEARALENONE, TOXICITY, BINDING, RATS

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MLA
Meerpoel, Celine, et al. “Comprehensive Toxicokinetic Analysis Reveals Major Interspecies Differences in Absorption, Distribution and Elimination of Citrinin in Pigs and Broiler Chickens.” FOOD AND CHEMICAL TOXICOLOGY, vol. 141, 2020, doi:10.1016/j.fct.2020.111365.
APA
Meerpoel, C., Vidal Corominas, A., Huybrechts, B., Tangni, E. K., De Saeger, S., Croubels, S., & Devreese, M. (2020). Comprehensive toxicokinetic analysis reveals major interspecies differences in absorption, distribution and elimination of citrinin in pigs and broiler chickens. FOOD AND CHEMICAL TOXICOLOGY, 141. https://doi.org/10.1016/j.fct.2020.111365
Chicago author-date
Meerpoel, Celine, Arnau Vidal Corominas, Bart Huybrechts, Emmanuel K. Tangni, Sarah De Saeger, Siska Croubels, and Mathias Devreese. 2020. “Comprehensive Toxicokinetic Analysis Reveals Major Interspecies Differences in Absorption, Distribution and Elimination of Citrinin in Pigs and Broiler Chickens.” FOOD AND CHEMICAL TOXICOLOGY 141. https://doi.org/10.1016/j.fct.2020.111365.
Chicago author-date (all authors)
Meerpoel, Celine, Arnau Vidal Corominas, Bart Huybrechts, Emmanuel K. Tangni, Sarah De Saeger, Siska Croubels, and Mathias Devreese. 2020. “Comprehensive Toxicokinetic Analysis Reveals Major Interspecies Differences in Absorption, Distribution and Elimination of Citrinin in Pigs and Broiler Chickens.” FOOD AND CHEMICAL TOXICOLOGY 141. doi:10.1016/j.fct.2020.111365.
Vancouver
1.
Meerpoel C, Vidal Corominas A, Huybrechts B, Tangni EK, De Saeger S, Croubels S, et al. Comprehensive toxicokinetic analysis reveals major interspecies differences in absorption, distribution and elimination of citrinin in pigs and broiler chickens. FOOD AND CHEMICAL TOXICOLOGY. 2020;141.
IEEE
[1]
C. Meerpoel et al., “Comprehensive toxicokinetic analysis reveals major interspecies differences in absorption, distribution and elimination of citrinin in pigs and broiler chickens,” FOOD AND CHEMICAL TOXICOLOGY, vol. 141, 2020.
@article{8662031,
  abstract     = {A comprehensive toxicokinetic analysis of citrinin (CIT) revealed interspecies differences for all toxicokinetic parameters and in absolute oral bioavailability. Oral bioavailability for CIT was complete for broilers (113-131%), while ranging from 37 to 44% in pigs. CIT was more rapidly absorbed in pigs (T-max = 0.92 h) compared to broiler chickens (T-max = 7.33 h). The elimination of CIT was slower in pigs (T-1/2el = 26.81 h after intravenous (IV) administration) compared to chickens (T-1/2el = 1.97 h after IV administration), due to the striking difference in clearance (Cl-iv =9.87 mL/h/kg for pigs versus Cl-iv = 863.09 mL/h/kg for broilers). Also, the volume of distribution differed significantly between pigs (Vd = 0.30 L/kg after IV administration) and chickens (Vd = 2.46 L/kg after IV administration). However, plasma protein binding did not differ statistically significant (91-98%). It is imperative to further investigate biotransformation and elimination pathways in different species, including humans.},
  articleno    = {111365},
  author       = {Meerpoel, Celine and Vidal Corominas, Arnau and Huybrechts, Bart and Tangni, Emmanuel K. and De Saeger, Sarah and Croubels, Siska and Devreese, Mathias},
  issn         = {0278-6915},
  journal      = {FOOD AND CHEMICAL TOXICOLOGY},
  keywords     = {Toxicology,Food Science,General Medicine,OCHRATOXIN-A,METABOLITE DIHYDROCITRINONE,MYCOTOXIN CITRININ,NEPHROTOXICITY,ZEARALENONE,TOXICITY,BINDING,RATS},
  language     = {eng},
  pages        = {9},
  title        = {Comprehensive toxicokinetic analysis reveals major interspecies differences in absorption, distribution and elimination of citrinin in pigs and broiler chickens},
  url          = {http://dx.doi.org/10.1016/j.fct.2020.111365},
  volume       = {141},
  year         = {2020},
}

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