@article{8661728,
  abstract     = {{Background: The prognostic value of tumour-infiltrating lymphocytes (TILs) differs by breast cancer (BC) subtype. The aim of this study was to evaluate TILs in stage III BC in the context of BRCA1/2-like phenotypes and association with outcome and benefit of intensified platinum-based chemotherapy.

Patients and methods: Patients participated in a randomised controlled trial of adjuvant intensified platinum-based chemotherapy versus conventional anthracycline-based chemotherapy carried out between 1993 and 1999 in stage III BC. Stromal TILs were scored according to International guidelines in these human epidermal growth factor receptor 2 (HER2)-negative tumours. BRCA-profiles were determined using Comparative Genomic Hybridization.

Results: TIL levels were evaluated in 248 BCs. High TILs were associated with Triple Negative BC (TNBC). BRCA-like tumours harboured higher TILs compared to non-BRCA-like tumours (median TILs of 20% versus 10%, p < 0.01). TIL levels in BRCA1-like tumours were higher compared to BRCA2-like tumours (median TILs of 20% versus 10%, p < 0.001). These correlations remained significant within the oestrogen (ER)-positive subgroup, however not within the TNBC subgroup. In this stage III BC cohort, high TIL level was associated with favourable outcome (TILs per 10% increment, recurrence-free survival (RFS): multivariate hazard ratio (HR) 0.82, 95% confidence interval (CI) 0.71-0.94, p = 0.01; overall survival (OS): multivariate HR 0.80, 95% CI 0.68-0.94, pZ0.01). There was no significant interaction between TILs and benefit of intensified platinum-based chemotherapy.

Conclusion: In this high-risk breast cancer cohort, high TILs were associated with TNBC and BRCA1-like status. Within the ER-positive subgroup, TIL levels were higher in BRCA1-like compared to BRCA2-like tumours. When adjusted for clinical characteristics, TILs were significantly associated with a more favourable outcome in stage III BC patients.}},
  author       = {{de Boo, Leonora and Cimino-Mathews, Ashley and Lubeck, Yoni and Daletzakis, Antonios and Opdam, Mark and Sanders, Joyce and Hooijberg, Erik and van Rossum, Annelot and Loncova, Zuzana and Rieder, Dietmar and Trajanoski, Zlatko and Vollebergh, Marieke and Sobral-Leite, Marcelo and Van de Vijver, Koen and Broeks, Annegien and van der Wiel, Rianne and van Tinteren, Harm and Linn, Sabine and Horlings, Hugo Mark and Kok, Marleen}},
  issn         = {{0959-8049}},
  journal      = {{European Journal of Cancer}},
  keywords     = {{Cancer Research,Oncology}},
  language     = {{eng}},
  pages        = {{240--250}},
  publisher    = {{ELSEVIER SCI LTD}},
  title        = {{Tumour-infiltrating lymphocytes (TILs) and BRCA-like status in stage III breast cancer patients randomised to adjuvant intensified platinum-based chemotherapy versus conventional chemotherapy}},
  url          = {{http://doi.org/10.1016/j.ejca.2019.12.003}},
  volume       = {{127}},
  year         = {{2020}},
}

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