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RIPK1 kinase-dependent death : a symphony of phosphorylation events

Tom Delanghe (UGent) , Yves Dondelinger (UGent) and Mathieu Bertrand (UGent)
(2020) TRENDS IN CELL BIOLOGY. 30(3). p.189-200
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Abstract
The serine/threonine kinase RIPK1 has emerged as a crucial component of the inflammatory response activated downstream of several immune receptors, where it paradoxically functions as a scaffold to protect the cell from death or instead as an active kinase to promote the killing of the cell. While RIPK1 kinase-dependent cell death has revealed its physiological importance in the context of microbial infection, aberrant activation of RIPK1 is also demonstrated to promote cell death-driven inflammatory pathologies, highlighting the importance of fundamentally understanding proper RIPK1 regulation. Recent advances in the field demonstrated the crucial role of phosphorylation in the fine-tuning of RIPK1 activation and, additionally, question the exact mechanism by which RIPK1 enzymatic activity transmits the death signal.
Keywords
NF-KAPPA-B, CELL-DEATH, CATALYTIC SUBUNIT, NECROPTOSIS, INFLAMMATION, APOPTOSIS, MUTATIONS, NECROSIS, LIGASES, CIAP1

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Please use this url to cite or link to this publication:

MLA
Delanghe, Tom, et al. “RIPK1 Kinase-Dependent Death : A Symphony of Phosphorylation Events.” TRENDS IN CELL BIOLOGY, vol. 30, no. 3, 2020, pp. 189–200.
APA
Delanghe, T., Dondelinger, Y., & Bertrand, M. (2020). RIPK1 kinase-dependent death : a symphony of phosphorylation events. TRENDS IN CELL BIOLOGY, 30(3), 189–200.
Chicago author-date
Delanghe, Tom, Yves Dondelinger, and Mathieu Bertrand. 2020. “RIPK1 Kinase-Dependent Death : A Symphony of Phosphorylation Events.” TRENDS IN CELL BIOLOGY 30 (3): 189–200.
Chicago author-date (all authors)
Delanghe, Tom, Yves Dondelinger, and Mathieu Bertrand. 2020. “RIPK1 Kinase-Dependent Death : A Symphony of Phosphorylation Events.” TRENDS IN CELL BIOLOGY 30 (3): 189–200.
Vancouver
1.
Delanghe T, Dondelinger Y, Bertrand M. RIPK1 kinase-dependent death : a symphony of phosphorylation events. TRENDS IN CELL BIOLOGY. 2020;30(3):189–200.
IEEE
[1]
T. Delanghe, Y. Dondelinger, and M. Bertrand, “RIPK1 kinase-dependent death : a symphony of phosphorylation events,” TRENDS IN CELL BIOLOGY, vol. 30, no. 3, pp. 189–200, 2020.
@article{8661634,
  abstract     = {The serine/threonine kinase RIPK1 has emerged as a crucial component of the inflammatory response activated downstream of several immune receptors, where it paradoxically functions as a scaffold to protect the cell from death or instead as an active kinase to promote the killing of the cell. While RIPK1 kinase-dependent cell death has revealed its physiological importance in the context of microbial infection, aberrant activation of RIPK1 is also demonstrated to promote cell death-driven inflammatory pathologies, highlighting the importance of fundamentally understanding proper RIPK1 regulation. Recent advances in the field demonstrated the crucial role of phosphorylation in the fine-tuning of RIPK1 activation and, additionally, question the exact mechanism by which RIPK1 enzymatic activity transmits the death signal.},
  author       = {Delanghe, Tom and Dondelinger, Yves and Bertrand, Mathieu},
  issn         = {0962-8924},
  journal      = {TRENDS IN CELL BIOLOGY},
  keywords     = {NF-KAPPA-B,CELL-DEATH,CATALYTIC SUBUNIT,NECROPTOSIS,INFLAMMATION,APOPTOSIS,MUTATIONS,NECROSIS,LIGASES,CIAP1},
  language     = {eng},
  number       = {3},
  pages        = {189--200},
  title        = {RIPK1 kinase-dependent death : a symphony of phosphorylation events},
  url          = {http://dx.doi.org/10.1016/j.tcb.2019.12.009},
  volume       = {30},
  year         = {2020},
}

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