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Guidelines and definitions for research on epithelial–mesenchymal transition

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Abstract
Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.
Keywords
Cell Biology, Molecular Biology, TRANSCRIPTION FACTOR SNAIL, FIBROBLAST-GROWTH-FACTOR, E-CADHERIN EXPRESSION, REPRESSES E-CADHERIN, NEURAL CREST CELLS, EMBRYONIC HEART, LUNG METASTASIS, COLLAGEN GELS, EMT, PLASTICITY

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Citation

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MLA
Yang, Jing, et al. “Guidelines and Definitions for Research on Epithelial–Mesenchymal Transition.” NATURE REVIEWS MOLECULAR CELL BIOLOGY, vol. 21, no. 6, 2020, pp. 341–52, doi:10.1038/s41580-020-0237-9.
APA
Yang, J., Antin, P., Berx, G., Blanpain, C., Brabletz, T., Bronner, M., … Sheng, G. (2020). Guidelines and definitions for research on epithelial–mesenchymal transition. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 21(6), 341–352. https://doi.org/10.1038/s41580-020-0237-9
Chicago author-date
Yang, Jing, Parker Antin, Geert Berx, Cédric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, et al. 2020. “Guidelines and Definitions for Research on Epithelial–Mesenchymal Transition.” NATURE REVIEWS MOLECULAR CELL BIOLOGY 21 (6): 341–52. https://doi.org/10.1038/s41580-020-0237-9.
Chicago author-date (all authors)
Yang, Jing, Parker Antin, Geert Berx, Cédric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, Amparo Cano, Jordi Casanova, Gerhard Christofori, Shoukat Dedhar, Rik Derynck, Heide L. Ford, Jonas Fuxe, Antonio García de Herreros, Gregory J. Goodall, Anna-Katerina Hadjantonakis, Ruby J. Y. Huang, Chaya Kalcheim, Raghu Kalluri, Yibin Kang, Yeesim Khew-Goodall, Herbert Levine, Jinsong Liu, Gregory D. Longmore, Sendurai A. Mani, Joan Massagué, Roberto Mayor, David McClay, Keith E. Mostov, Donald F. Newgreen, M. Angela Nieto, Alain Puisieux, Raymond Runyan, Pierre Savagner, Ben Stanger, Marc P. Stemmler, Yoshiko Takahashi, Masatoshi Takeichi, Eric Theveneau, Jean Paul Thiery, Erik W. Thompson, Robert A. Weinberg, Elizabeth D. Williams, Jianhua Xing, Binhua P. Zhou, and Guojun Sheng. 2020. “Guidelines and Definitions for Research on Epithelial–Mesenchymal Transition.” NATURE REVIEWS MOLECULAR CELL BIOLOGY 21 (6): 341–352. doi:10.1038/s41580-020-0237-9.
Vancouver
1.
Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, et al. Guidelines and definitions for research on epithelial–mesenchymal transition. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2020;21(6):341–52.
IEEE
[1]
J. Yang et al., “Guidelines and definitions for research on epithelial–mesenchymal transition,” NATURE REVIEWS MOLECULAR CELL BIOLOGY, vol. 21, no. 6, pp. 341–352, 2020.
@article{8661599,
  abstract     = {Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.},
  author       = {Yang, Jing and Antin, Parker and Berx, Geert and Blanpain, Cédric and Brabletz, Thomas and Bronner, Marianne and Campbell, Kyra and Cano, Amparo and Casanova, Jordi and Christofori, Gerhard and Dedhar, Shoukat and Derynck, Rik and Ford, Heide L. and Fuxe, Jonas and García de Herreros, Antonio and Goodall, Gregory J. and Hadjantonakis, Anna-Katerina and Huang, Ruby J. Y. and Kalcheim, Chaya and Kalluri, Raghu and Kang, Yibin and Khew-Goodall, Yeesim and Levine, Herbert and Liu, Jinsong and Longmore, Gregory D. and Mani, Sendurai A. and Massagué, Joan and Mayor, Roberto and McClay, David and Mostov, Keith E. and Newgreen, Donald F. and Nieto, M. Angela and Puisieux, Alain and Runyan, Raymond and Savagner, Pierre and Stanger, Ben and Stemmler, Marc P. and Takahashi, Yoshiko and Takeichi, Masatoshi and Theveneau, Eric and Thiery, Jean Paul and Thompson, Erik W. and Weinberg, Robert A. and Williams, Elizabeth D. and Xing, Jianhua and Zhou, Binhua P. and Sheng, Guojun},
  issn         = {1471-0072},
  journal      = {NATURE REVIEWS MOLECULAR CELL BIOLOGY},
  keywords     = {Cell Biology,Molecular Biology,TRANSCRIPTION FACTOR SNAIL,FIBROBLAST-GROWTH-FACTOR,E-CADHERIN EXPRESSION,REPRESSES E-CADHERIN,NEURAL CREST CELLS,EMBRYONIC HEART,LUNG METASTASIS,COLLAGEN GELS,EMT,PLASTICITY},
  language     = {eng},
  number       = {6},
  pages        = {341--352},
  title        = {Guidelines and definitions for research on epithelial–mesenchymal transition},
  url          = {http://dx.doi.org/10.1038/s41580-020-0237-9},
  volume       = {21},
  year         = {2020},
}

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