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Host cell factors as antiviral targets in arenavirus infection

(2012) VIRUSES-BASEL. 4(9). p.1569-1591
Author
Organization
Abstract
Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively. Given the human health threat that arenaviruses represent and the lack of a specific and safe chemotherapy, the search for effective antiviral compounds is a continuous demanding effort. Since diverse host cell pathways and enzymes are used by RNA viruses to fulfill their replicative cycle, the targeting of a host process has turned an attractive antiviral approach in the last years for many unrelated virus types. This strategy has the additional benefit to reduce the serious challenge for therapy of RNA viruses to escape from drug effects through selection of resistant variants triggered by their high mutation rate. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing the potential for antiviral developments of diverse host factors essential for virus infection.
Keywords
arenavirus, Junin virus, hemorrhagic fever, antiviral, host cell target, LYMPHOCYTIC-CHORIOMENINGITIS-VIRUS, PROMYELOCYTIC LEUKEMIA PROTEIN, PML NUCLEAR-BODIES, INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE, I INTERFERON RESPONSE, HUMAN DENDRITIC CELLS, PATHOGENIC OLD-WORLD, LASSA VIRUS, SIGNAL-TRANSDUCTION, PICHINDE VIRUS

Citation

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MLA
Linero, Florencia, et al. “Host Cell Factors as Antiviral Targets in Arenavirus Infection.” VIRUSES-BASEL, vol. 4, no. 9, 2012, pp. 1569–91, doi:10.3390/v4091569.
APA
Linero, F., Sepúlveda, C. S., Giovannoni, F., Castilla, V., García, C. C., Scolaro, L. A., & Damonte, E. B. (2012). Host cell factors as antiviral targets in arenavirus infection. VIRUSES-BASEL, 4(9), 1569–1591. https://doi.org/10.3390/v4091569
Chicago author-date
Linero, Florencia, Claudia S. Sepúlveda, Federico Giovannoni, Viviana Castilla, Cybele C. García, Luis A. Scolaro, and Elsa B. Damonte. 2012. “Host Cell Factors as Antiviral Targets in Arenavirus Infection.” VIRUSES-BASEL 4 (9): 1569–91. https://doi.org/10.3390/v4091569.
Chicago author-date (all authors)
Linero, Florencia, Claudia S. Sepúlveda, Federico Giovannoni, Viviana Castilla, Cybele C. García, Luis A. Scolaro, and Elsa B. Damonte. 2012. “Host Cell Factors as Antiviral Targets in Arenavirus Infection.” VIRUSES-BASEL 4 (9): 1569–1591. doi:10.3390/v4091569.
Vancouver
1.
Linero F, Sepúlveda CS, Giovannoni F, Castilla V, García CC, Scolaro LA, et al. Host cell factors as antiviral targets in arenavirus infection. VIRUSES-BASEL. 2012;4(9):1569–91.
IEEE
[1]
F. Linero et al., “Host cell factors as antiviral targets in arenavirus infection,” VIRUSES-BASEL, vol. 4, no. 9, pp. 1569–1591, 2012.
@article{8661490,
  abstract     = {{Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively. Given the human health threat that arenaviruses represent and the lack of a specific and safe chemotherapy, the search for effective antiviral compounds is a continuous demanding effort. Since diverse host cell pathways and enzymes are used by RNA viruses to fulfill their replicative cycle, the targeting of a host process has turned an attractive antiviral approach in the last years for many unrelated virus types. This strategy has the additional benefit to reduce the serious challenge for therapy of RNA viruses to escape from drug effects through selection of resistant variants triggered by their high mutation rate. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing the potential for antiviral developments of diverse host factors essential for virus infection.}},
  author       = {{Linero, Florencia and Sepúlveda, Claudia S. and Giovannoni, Federico and Castilla, Viviana and García, Cybele C. and Scolaro, Luis A. and Damonte, Elsa B.}},
  issn         = {{1999-4915}},
  journal      = {{VIRUSES-BASEL}},
  keywords     = {{arenavirus,Junin virus,hemorrhagic fever,antiviral,host cell target,LYMPHOCYTIC-CHORIOMENINGITIS-VIRUS,PROMYELOCYTIC LEUKEMIA PROTEIN,PML NUCLEAR-BODIES,INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE,I INTERFERON RESPONSE,HUMAN DENDRITIC CELLS,PATHOGENIC OLD-WORLD,LASSA VIRUS,SIGNAL-TRANSDUCTION,PICHINDE VIRUS}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1569--1591}},
  title        = {{Host cell factors as antiviral targets in arenavirus infection}},
  url          = {{http://dx.doi.org/10.3390/v4091569}},
  volume       = {{4}},
  year         = {{2012}},
}

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