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The use of force plate measurements to titrate the dosage of a new COX-2 inhibitor in lame horses

Willem Back UGent, CG MacAllister, MCV van Heel, M Pollmeier and PD Hanson (2009) EQUINE VETERINARY JOURNAL. 41(3). p.309-312
abstract
Reasons for performing study: Lameness is a highly prevalent condition in horses and the principal cause of removal from athletic activity. In clinical studies to evaluate nonsteroidal anti-inflammatory drug therapies, force plates are commonly used to assess improvement of lameness objectively. Hypothesis: To use a force plate to determine the optimal dose of a new COX-2 inhibitor (firocoxib) that will reduce lameness, when administered orally to horses once daily. Methods: Sixty-four horses that exhibited chronic lameness presumed due to osteoarthritis, including navicular disease, in at least one of the frontlimbs and at a stable level of severity, were included. Horses were treated per os s.i.d. for 7 days as follows: vehicle control, firocoxib at 0.05, 0.1 or 0.25 mg/kg bwt. Force plate analysis of each horse was done for the selected (most) lame frontlimb at trot. Once between Days -19 and -4 (initial examination), and again on Day -2 or -1 (baseline), pretreatment force plate assessments were performed, and thereafter horses were assessed on Days 0, 2 and 6, approximately 10 h post treatment each time. Peak vertical force (PVF) and lameness grades at initial examination and at baseline, and their change from baseline in the 4 different treatment groups were analysed statistically at a significance level of P<0.05. Results: The PVF results were found to be superior to vehicle control already at Day 0 for 0.25 mg/kg bwt and at Days 2 and 6 for 0.1 and 0.25 mg/kg bwt (P<0.05). Mean clinical lameness for both concentrations decreased >1 grade at Day 6. Conclusions and clinical relevance: With the dosage of 0.25 mg/kg bwt lameness did not improve more than with 0.1 mg/kg bwt. Thus, 0.1 mg/kg bwt s.i.d. was considered to be the effective dose at reducing chronic lameness in horses presumed due to osteoarthritis, including navicular disease.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (proceedingsPaper)
publication status
published
subject
keyword
FLUNIXIN MEGLUMINE, pain-relieving medication, PHENYLBUTAZONE, QUARTER HORSES, NAVICULAR SYNDROME, NSAID, locomotion, horse, kinetics, lameness
journal title
EQUINE VETERINARY JOURNAL
Equine Vet. J.
volume
41
issue
3
pages
4 pages
conference name
6th International Conference on Equine Locomotion
conference location
Cabourg, France
conference start
2008-06-16
conference end
2008-06-19
Web of Science type
Proceedings Paper
Web of Science id
000264140600024
JCR category
VETERINARY SCIENCES
JCR impact factor
1.837 (2009)
JCR rank
18/141 (2009)
JCR quartile
1 (2009)
ISSN
0425-1644
DOI
10.2746/042516409X397118
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
866103
handle
http://hdl.handle.net/1854/LU-866103
date created
2010-02-17 15:16:35
date last changed
2010-03-11 11:53:55
@article{866103,
  abstract     = {Reasons for performing study: Lameness is a highly prevalent condition in horses and the principal cause of removal from athletic activity. In clinical studies to evaluate nonsteroidal anti-inflammatory drug therapies, force plates are commonly used to assess improvement of lameness objectively.
Hypothesis: To use a force plate to determine the optimal dose of a new COX-2 inhibitor (firocoxib) that will reduce lameness, when administered orally to horses once daily.
Methods: Sixty-four horses that exhibited chronic lameness presumed due to osteoarthritis, including navicular disease, in at least one of the frontlimbs and at a stable level of severity, were included. Horses were treated per os s.i.d. for 7 days as follows: vehicle control, firocoxib at 0.05, 0.1 or 0.25 mg/kg bwt. Force plate analysis of each horse was done for the selected (most) lame frontlimb at trot. Once between Days -19 and -4 (initial examination), and again on Day -2 or -1 (baseline), pretreatment force plate assessments were performed, and thereafter horses were assessed on Days 0, 2 and 6, approximately 10 h post treatment each time. Peak vertical force (PVF) and lameness grades at initial examination and at baseline, and their change from baseline in the 4 different treatment groups were analysed statistically at a significance level of P{\textlangle}0.05.
Results: The PVF results were found to be superior to vehicle control already at Day 0 for 0.25 mg/kg bwt and at Days 2 and 6 for 0.1 and 0.25 mg/kg bwt (P{\textlangle}0.05). Mean clinical lameness for both concentrations decreased {\textrangle}1 grade at Day 6.
Conclusions and clinical relevance: With the dosage of 0.25 mg/kg bwt lameness did not improve more than with 0.1 mg/kg bwt. Thus, 0.1 mg/kg bwt s.i.d. was considered to be the effective dose at reducing chronic lameness in horses presumed due to osteoarthritis, including navicular disease.},
  author       = {Back, Willem and MacAllister, CG and van Heel, MCV and Pollmeier, M and Hanson, PD},
  issn         = {0425-1644},
  journal      = {EQUINE VETERINARY JOURNAL},
  keyword      = {FLUNIXIN MEGLUMINE,pain-relieving medication,PHENYLBUTAZONE,QUARTER HORSES,NAVICULAR SYNDROME,NSAID,locomotion,horse,kinetics,lameness},
  language     = {eng},
  location     = {Cabourg, France},
  number       = {3},
  pages        = {309--312},
  title        = {The use of force plate measurements to titrate the dosage of a new COX-2 inhibitor in lame horses},
  url          = {http://dx.doi.org/10.2746/042516409X397118},
  volume       = {41},
  year         = {2009},
}

Chicago
Back, Willem, CG MacAllister, MCV van Heel, M Pollmeier, and PD Hanson. 2009. “The Use of Force Plate Measurements to Titrate the Dosage of a New COX-2 Inhibitor in Lame Horses.” Equine Veterinary Journal 41 (3): 309–312.
APA
Back, W., MacAllister, C., van Heel, M., Pollmeier, M., & Hanson, P. (2009). The use of force plate measurements to titrate the dosage of a new COX-2 inhibitor in lame horses. EQUINE VETERINARY JOURNAL, 41(3), 309–312. Presented at the 6th International Conference on Equine Locomotion.
Vancouver
1.
Back W, MacAllister C, van Heel M, Pollmeier M, Hanson P. The use of force plate measurements to titrate the dosage of a new COX-2 inhibitor in lame horses. EQUINE VETERINARY JOURNAL. 2009;41(3):309–12.
MLA
Back, Willem, CG MacAllister, MCV van Heel, et al. “The Use of Force Plate Measurements to Titrate the Dosage of a New COX-2 Inhibitor in Lame Horses.” EQUINE VETERINARY JOURNAL 41.3 (2009): 309–312. Print.