Advanced search
1 file | 163.65 KB

Quantification of surface EMG signals to monitor the effect of a Botox treatment in six healthy ponies and two horses with stringhalt: preliminary study

(2009) EQUINE VETERINARY JOURNAL. 41(3). p.313-318
Author
Organization
Abstract
Reasons for performing the study: Therapeutic options for stringhalt in horses are limited, whereas medical experiences with botulinum toxin type A (Botox) have been positive. To evaluate its effectiveness in horses, surface electromyography (sEMG) signals before and after injection need to be quantified. Hypothesis: Treatment of healthy ponies and cases with Botox should reduce muscle activity in injected muscles and reduce spastic movements without adverse side effects. Methods: Unilaterally, the extensor digitorum longus, extensor digitorum lateralis and lateral vastus muscles of 6 healthy mature Shetland ponies and 2 talented Dutch Warmblood dressage horses with stringhalt were injected (maximum of 400 iu per pony and 700 in per case; 100 in in 5 ml NaCl divided into 5 injections) with Botox under needle EMG guidance. Surface EMG data were evaluated using customised software, and in the individuals gait was analysed using Proreflex. Statistical analysis was performed using mixed models and independent sample t test (P<0.05). Results: Surface EMG signals were quantified using customised software. The area under the curve (integrated EMG) in time was used as variable. It became significantly reduced in injected muscles after injection of Botox in normal ponies (P<0.05). This effect was present from Day 1 until Day 84 after injection. In the 2 cases, after injection of 3 muscles, the integrated EMG in time became significantly reduced in all 3 muscles. Kinematic measurements confirmed reduction of frequency and amplitude of hyperflexing or hyperabducting strides of the affected hindlimbs. The duration of effect was also seen in the cases until around 12 weeks after injection. Conclusions and potential relevance: After EMG guided injections of Botox, sEMG signals recorded from injected muscle were reduced, which proves this to be a useful tool in statistically evaluating a treatment effect. The positive results of this pilot study encourage further research with a larger group of clinical cases.
Keywords
DOUBLE-BLIND, TOXIN TYPE-A, AUSTRALIAN STRINGHALT, ADDUCTOR SPASTICITY, CLINICAL-DIAGNOSIS, MUSCLE PARALYSIS, ELECTROMYOGRAPHY, INJECTIONS, quantitative electromyography, muscle activity, hypermetria, botulinum toxin type A, horse, DYSPORT(R), BOTULINUM-TOXIN

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 163.65 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Wijnberg, ID, SEA Schrama, AE Elgersma, JTM Maree, P de Cocq, and Willem Back. 2009. “Quantification of Surface EMG Signals to Monitor the Effect of a Botox Treatment in Six Healthy Ponies and Two Horses with Stringhalt: Preliminary Study.” Equine Veterinary Journal 41 (3): 313–318.
APA
Wijnberg, ID, Schrama, S., Elgersma, A., Maree, J., de Cocq, P., & Back, W. (2009). Quantification of surface EMG signals to monitor the effect of a Botox treatment in six healthy ponies and two horses with stringhalt: preliminary study. EQUINE VETERINARY JOURNAL, 41(3), 313–318. Presented at the 6th International Conference on Equine Locomotion.
Vancouver
1.
Wijnberg I, Schrama S, Elgersma A, Maree J, de Cocq P, Back W. Quantification of surface EMG signals to monitor the effect of a Botox treatment in six healthy ponies and two horses with stringhalt: preliminary study. EQUINE VETERINARY JOURNAL. 2009;41(3):313–8.
MLA
Wijnberg, ID, SEA Schrama, AE Elgersma, et al. “Quantification of Surface EMG Signals to Monitor the Effect of a Botox Treatment in Six Healthy Ponies and Two Horses with Stringhalt: Preliminary Study.” EQUINE VETERINARY JOURNAL 41.3 (2009): 313–318. Print.
@article{866085,
  abstract     = {Reasons for performing the study: Therapeutic options for stringhalt in horses are limited, whereas medical experiences with botulinum toxin type A (Botox) have been positive. To evaluate its effectiveness in horses, surface electromyography (sEMG) signals before and after injection need to be quantified.
Hypothesis: Treatment of healthy ponies and cases with Botox should reduce muscle activity in injected muscles and reduce spastic movements without adverse side effects.
Methods: Unilaterally, the extensor digitorum longus, extensor digitorum lateralis and lateral vastus muscles of 6 healthy mature Shetland ponies and 2 talented Dutch Warmblood dressage horses with stringhalt were injected (maximum of 400 iu per pony and 700 in per case; 100 in in 5 ml NaCl divided into 5 injections) with Botox under needle EMG guidance. Surface EMG data were evaluated using customised software, and in the individuals gait was analysed using Proreflex. Statistical analysis was performed using mixed models and independent sample t test (P{\textlangle}0.05).
Results: Surface EMG signals were quantified using customised software. The area under the curve (integrated EMG) in time was used as variable. It became significantly reduced in injected muscles after injection of Botox in normal ponies (P{\textlangle}0.05). This effect was present from Day 1 until Day 84 after injection. In the 2 cases, after injection of 3 muscles, the integrated EMG in time became significantly reduced in all 3 muscles. Kinematic measurements confirmed reduction of frequency and amplitude of hyperflexing or hyperabducting strides of the affected hindlimbs. The duration of effect was also seen in the cases until around 12 weeks after injection.
Conclusions and potential relevance: After EMG guided injections of Botox, sEMG signals recorded from injected muscle were reduced, which proves this to be a useful tool in statistically evaluating a treatment effect. The positive results of this pilot study encourage further research with a larger group of clinical cases.},
  author       = {Wijnberg, ID and Schrama, SEA and Elgersma, AE and Maree, JTM and de Cocq, P and Back, Willem},
  issn         = {0425-1644},
  journal      = {EQUINE VETERINARY JOURNAL},
  language     = {eng},
  location     = {Cabourg, France},
  number       = {3},
  pages        = {313--318},
  title        = {Quantification of surface EMG signals to monitor the effect of a Botox treatment in six healthy ponies and two horses with stringhalt: preliminary study},
  url          = {http://dx.doi.org/10.2746/042516409X397361},
  volume       = {41},
  year         = {2009},
}

Altmetric
View in Altmetric
Web of Science
Times cited: