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A medical information system for monitoring respiratory function and related nonlinear dynamics

Mihaela Ghita (UGent) , Dana Copot (UGent) , Maria Ghita (UGent) and Clara-Mihaela Ionescu (UGent)
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Abstract
In this paper the nonlinear effects in the respiratory systems at low frequencies are measured and evaluated in healthy children and healthy adults. To this aim forced oscillations technique (FOT) has been used to non-invasively measure the lung tissue mechanics. FOT does not require any special effort from the patient in contrast with standardized tests where maneuvers are necessary. Hence, FOT is an ideal lung function test for extreme ages, more specifically children and elderly, given the simpleness of measurement technique. Hitherto, measurements at low frequencies (i.e. close to the breathing frequency similar to 0.3 Hz) have been invasively performed in sacrificed animals and on anesthetized humans. Here we measure in the frequency interval 0.1-2 Hz a total number of 94 volunteers (37 adults with ages between 25-35 years and 57 children with ages between 8-11 years). To evaluate the nonlinear contributions of the respiratory tissue, a novel T-index has been introduced. We have tested the hypothesis whether the nonlinear distortions are changing with growth/development of the respiratory tree and aim to quantify its dependence to biometric values. The results obtained indicate that the proposed index can differentiate between the two analyzed groups and that there is a dependence to age, height and weight. A medical information system may use this information to update predictions of respiratory function and provide aid in decision-making process of drug therapy.
Keywords
FORCED OSCILLATION TECHNIQUE, AIR-FLOW OBSTRUCTION, CAT LUNG, MECHANICS, IMPEDANCE, DEVICE, ASTHMA

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MLA
Ghita, Mihaela, et al. “A Medical Information System for Monitoring Respiratory Function and Related Nonlinear Dynamics.” 2019 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC), IEEE, 2019, pp. 330–35.
APA
Ghita, M., Copot, D., Ghita, M., & Ionescu, C.-M. (2019). A medical information system for monitoring respiratory function and related nonlinear dynamics. In 2019 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC) (pp. 330–335). Bari, Italy: IEEE.
Chicago author-date
Ghita, Mihaela, Dana Copot, Maria Ghita, and Clara-Mihaela Ionescu. 2019. “A Medical Information System for Monitoring Respiratory Function and Related Nonlinear Dynamics.” In 2019 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC), 330–35. IEEE.
Chicago author-date (all authors)
Ghita, Mihaela, Dana Copot, Maria Ghita, and Clara-Mihaela Ionescu. 2019. “A Medical Information System for Monitoring Respiratory Function and Related Nonlinear Dynamics.” In 2019 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC), 330–335. IEEE.
Vancouver
1.
Ghita M, Copot D, Ghita M, Ionescu C-M. A medical information system for monitoring respiratory function and related nonlinear dynamics. In: 2019 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC). IEEE; 2019. p. 330–5.
IEEE
[1]
M. Ghita, D. Copot, M. Ghita, and C.-M. Ionescu, “A medical information system for monitoring respiratory function and related nonlinear dynamics,” in 2019 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC), Bari, Italy, 2019, pp. 330–335.
@inproceedings{8660339,
  abstract     = {In this paper the nonlinear effects in the respiratory systems at low frequencies are measured and evaluated in healthy children and healthy adults. To this aim forced oscillations technique (FOT) has been used to non-invasively measure the lung tissue mechanics. FOT does not require any special effort from the patient in contrast with standardized tests where maneuvers are necessary. Hence, FOT is an ideal lung function test for extreme ages, more specifically children and elderly, given the simpleness of measurement technique. Hitherto, measurements at low frequencies (i.e. close to the breathing frequency similar to 0.3 Hz) have been invasively performed in sacrificed animals and on anesthetized humans. Here we measure in the frequency interval 0.1-2 Hz a total number of 94 volunteers (37 adults with ages between 25-35 years and 57 children with ages between 8-11 years). To evaluate the nonlinear contributions of the respiratory tissue, a novel T-index has been introduced. We have tested the hypothesis whether the nonlinear distortions are changing with growth/development of the respiratory tree and aim to quantify its dependence to biometric values. The results obtained indicate that the proposed index can differentiate between the two analyzed groups and that there is a dependence to age, height and weight. A medical information system may use this information to update predictions of respiratory function and provide aid in decision-making process of drug therapy.},
  author       = {Ghita, Mihaela and Copot, Dana and Ghita, Maria and Ionescu, Clara-Mihaela},
  booktitle    = {2019 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC)},
  isbn         = {9781728145693},
  keywords     = {FORCED OSCILLATION TECHNIQUE,AIR-FLOW OBSTRUCTION,CAT LUNG,MECHANICS,IMPEDANCE,DEVICE,ASTHMA},
  language     = {eng},
  location     = {Bari, Italy},
  pages        = {330--335},
  publisher    = {IEEE},
  title        = {A medical information system for monitoring respiratory function and related nonlinear dynamics},
  url          = {http://dx.doi.org/10.1109/smc.2019.8914485},
  year         = {2019},
}

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