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Normal function of the hypothalamic-pituitary growth axis in three dwarf Friesian foals

E de Graaf-Roelfsema, Willem Back UGent, HA Keizer, TAE Stout and JH van der Kolk (2009) VETERINARY RECORD. 165(13). p.373-376
abstract
Serial blood samples were collected from three dwarf Friesian foals to examine their endogenous growth hormone (GH) profiles, and the integrity of the GH-insulin-like growth factor-I (IGF-I) axis was tested in one of them by examining its responses to the administration of GH-releasing hormone (GHRH) and to 10 days of treatment with recombinant equine GH. The basal serum concentrations of IGF-I in the three dwarf foals were compared with those in nine age-matched normal foals. All the dwarf foals secreted endogenous GH. Stimulation with 7.0 mu g/kg GHRH led to a 1400 per cent increase in plasma GH concentration in the dwarf foal tested, and 10 daily subcutaneous treatments with 20 mu g/kg recombinant equine GH led to a 100 per cent increase in its serum IGF-I concentration. The basal serum concentrations of IGF-I in the dwarf foals were not significantly different from those of the normal foals.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
HORSES, IGF-I, ANIMAL-MODELS, LARON-SYNDROME, HORMONE RESISTANCE, PLASMA-CONCENTRATIONS, GH, EQUINE SOMATOTROPIN, INSENSITIVITY, AGE
journal title
VETERINARY RECORD
Vet. Rec.
volume
165
issue
13
pages
4 pages
Web of Science type
Article
Web of Science id
000270422200014
JCR category
VETERINARY SCIENCES
JCR impact factor
1.504 (2009)
JCR rank
32/141 (2009)
JCR quartile
1 (2009)
ISSN
0042-4900
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
866016
handle
http://hdl.handle.net/1854/LU-866016
alternative location
http://veterinaryrecord.bvapublications.com/cgi/content/abstract/165/13/373
date created
2010-02-17 15:01:35
date last changed
2010-03-11 11:25:52
@article{866016,
  abstract     = {Serial blood samples were collected from three dwarf Friesian foals to examine their endogenous growth hormone (GH) profiles, and the integrity of the GH-insulin-like growth factor-I (IGF-I) axis was tested in one of them by examining its responses to the administration of GH-releasing hormone (GHRH) and to 10 days of treatment with recombinant equine GH. The basal serum concentrations of IGF-I in the three dwarf foals were compared with those in nine age-matched normal foals. All the dwarf foals secreted endogenous GH. Stimulation with 7.0 mu g/kg GHRH led to a 1400 per cent increase in plasma GH concentration in the dwarf foal tested, and 10 daily subcutaneous treatments with 20 mu g/kg recombinant equine GH led to a 100 per cent increase in its serum IGF-I concentration. The basal serum concentrations of IGF-I in the dwarf foals were not significantly different from those of the normal foals.},
  author       = {de Graaf-Roelfsema, E and Back, Willem and Keizer, HA and Stout, TAE and van der Kolk, JH},
  issn         = {0042-4900},
  journal      = {VETERINARY RECORD},
  keyword      = {HORSES,IGF-I,ANIMAL-MODELS,LARON-SYNDROME,HORMONE RESISTANCE,PLASMA-CONCENTRATIONS,GH,EQUINE SOMATOTROPIN,INSENSITIVITY,AGE},
  language     = {eng},
  number       = {13},
  pages        = {373--376},
  title        = {Normal function of the hypothalamic-pituitary growth axis in three dwarf Friesian foals},
  url          = {http://veterinaryrecord.bvapublications.com/cgi/content/abstract/165/13/373},
  volume       = {165},
  year         = {2009},
}

Chicago
de Graaf-Roelfsema, E, Willem Back, HA Keizer, TAE Stout, and JH van der Kolk. 2009. “Normal Function of the Hypothalamic-pituitary Growth Axis in Three Dwarf Friesian Foals.” Veterinary Record 165 (13): 373–376.
APA
de Graaf-Roelfsema, E., Back, W., Keizer, H., Stout, T., & van der Kolk, J. (2009). Normal function of the hypothalamic-pituitary growth axis in three dwarf Friesian foals. VETERINARY RECORD, 165(13), 373–376.
Vancouver
1.
de Graaf-Roelfsema E, Back W, Keizer H, Stout T, van der Kolk J. Normal function of the hypothalamic-pituitary growth axis in three dwarf Friesian foals. VETERINARY RECORD. 2009;165(13):373–6.
MLA
de Graaf-Roelfsema, E, Willem Back, HA Keizer, et al. “Normal Function of the Hypothalamic-pituitary Growth Axis in Three Dwarf Friesian Foals.” VETERINARY RECORD 165.13 (2009): 373–376. Print.