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An overview of the current genetic and phenotypical selection strategies to reduce the prevalence of feline hypertrophic cardiomyopathy = Een overzicht van de huidige genetische en fenotypische selectiestrategieën tegen hypertrofe cardiomyopathie bij de kat

Tom Schipper (UGent) , Luc Peelman (UGent) , Pascale Smets (UGent) and Bart Broeckx (UGent)
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Abstract
Hypertrophic cardiomyopathy (HCM) is a common and potentially lethal heart disease in cats. To reduce its prevalence, breeding cats are frequently screened on the basis of their phenotype or genotype. Although echocardiography is the most reliable phenotypical method, its efficacy is limited by the incomplete penetrance of HCM and by difficulties in distinguishing primary HCM from other causes of left ventricular hypertrophy. On the other hand, genetic testing is hampered by the genetic heterogeneity of the disease. Genetic tests are currently only available for Maine Coons and Ragdolls. Because of the high prevalence of HCM, stringent selection may have a negative impact on the genetic diversity of a breed. A more optimal selection would therefore be a slow and careful exclusion of phenotypically and/or genetically positive cats.
Keywords
MAINE COON CATS, PROTEIN-C MUTATION, MYOSIN STORAGE MYOPATHY, ARTERIAL THROMBOEMBOLISM, CLINICAL PRESENTATION, A31P MUTATION, ANIMAL-MODEL, SPHYNX CAT, POPULATION, DISEASE

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MLA
Schipper, Tom, et al. “An Overview of the Current Genetic and Phenotypical Selection Strategies to Reduce the Prevalence of Feline Hypertrophic Cardiomyopathy = Een Overzicht van de Huidige Genetische En Fenotypische Selectiestrategieën Tegen Hypertrofe Cardiomyopathie Bij de Kat.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, vol. 89, no. 2, 2020, pp. 69–80, doi:10.21825/vdt.v89i2.16355.
APA
Schipper, T., Peelman, L., Smets, P., & Broeckx, B. (2020). An overview of the current genetic and phenotypical selection strategies to reduce the prevalence of feline hypertrophic cardiomyopathy = Een overzicht van de huidige genetische en fenotypische selectiestrategieën tegen hypertrofe cardiomyopathie bij de kat. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 89(2), 69–80. https://doi.org/10.21825/vdt.v89i2.16355
Chicago author-date
Schipper, Tom, Luc Peelman, Pascale Smets, and Bart Broeckx. 2020. “An Overview of the Current Genetic and Phenotypical Selection Strategies to Reduce the Prevalence of Feline Hypertrophic Cardiomyopathy = Een Overzicht van de Huidige Genetische En Fenotypische Selectiestrategieën Tegen Hypertrofe Cardiomyopathie Bij de Kat.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 89 (2): 69–80. https://doi.org/10.21825/vdt.v89i2.16355.
Chicago author-date (all authors)
Schipper, Tom, Luc Peelman, Pascale Smets, and Bart Broeckx. 2020. “An Overview of the Current Genetic and Phenotypical Selection Strategies to Reduce the Prevalence of Feline Hypertrophic Cardiomyopathy = Een Overzicht van de Huidige Genetische En Fenotypische Selectiestrategieën Tegen Hypertrofe Cardiomyopathie Bij de Kat.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 89 (2): 69–80. doi:10.21825/vdt.v89i2.16355.
Vancouver
1.
Schipper T, Peelman L, Smets P, Broeckx B. An overview of the current genetic and phenotypical selection strategies to reduce the prevalence of feline hypertrophic cardiomyopathy = Een overzicht van de huidige genetische en fenotypische selectiestrategieën tegen hypertrofe cardiomyopathie bij de kat. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2020;89(2):69–80.
IEEE
[1]
T. Schipper, L. Peelman, P. Smets, and B. Broeckx, “An overview of the current genetic and phenotypical selection strategies to reduce the prevalence of feline hypertrophic cardiomyopathy = Een overzicht van de huidige genetische en fenotypische selectiestrategieën tegen hypertrofe cardiomyopathie bij de kat,” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, vol. 89, no. 2, pp. 69–80, 2020.
@article{8660096,
  abstract     = {{Hypertrophic cardiomyopathy (HCM) is a common and potentially lethal heart disease in cats. To reduce its prevalence, breeding cats are frequently screened on the basis of their phenotype or genotype. Although echocardiography is the most reliable phenotypical method, its efficacy is limited by the incomplete penetrance of HCM and by difficulties in distinguishing primary HCM from other causes of left ventricular hypertrophy. On the other hand, genetic testing is hampered by the genetic heterogeneity of the disease. Genetic tests are currently only available for Maine Coons and Ragdolls. Because of the high prevalence of HCM, stringent selection may have a negative impact on the genetic diversity of a breed. A more optimal selection would therefore be a slow and careful exclusion of phenotypically and/or genetically positive cats.}},
  author       = {{Schipper, Tom and Peelman, Luc and Smets, Pascale and Broeckx, Bart}},
  issn         = {{0303 9021}},
  journal      = {{VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT}},
  keywords     = {{MAINE COON CATS,PROTEIN-C MUTATION,MYOSIN STORAGE MYOPATHY,ARTERIAL THROMBOEMBOLISM,CLINICAL PRESENTATION,A31P MUTATION,ANIMAL-MODEL,SPHYNX CAT,POPULATION,DISEASE}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{69--80}},
  title        = {{An overview of the current genetic and phenotypical selection strategies to reduce the prevalence of feline hypertrophic cardiomyopathy = Een overzicht van de huidige genetische en fenotypische selectiestrategieën tegen hypertrofe cardiomyopathie bij de kat}},
  url          = {{http://dx.doi.org/10.21825/vdt.v89i2.16355}},
  volume       = {{89}},
  year         = {{2020}},
}

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