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Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review

Biao Han (UGent) , Sri Kartik Baruah (UGent) , Eric Cox (UGent) , Daisy Vanrompay (UGent) and Peter Bossier (UGent)
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Abstract
β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths. β-Glucans initiate immune responses via immune cells, which become activated by the binding of the polymer to specific receptors. However, β-glucans from different sources also differ in their structure, conformation, physical properties, binding affinity to receptors, and thus biological functions. The mechanisms behind this are not fully understood. This mini-review provides a comprehensive and up-to-date commentary on the relationship between β-glucans' structure and function in relation to their use for immunomodulation.
Keywords
beta-glucans, structure-function relationship, immunomodulation, molecular structure, molecular weight, solubility, MOLECULAR-WEIGHT, ANTITUMOR-ACTIVITY, IMMUNOSTIMULATORY ACTIVITY, BIOLOGICAL-ACTIVITIES, IMMUNE-RESPONSES, CELL-WALLS, POLYSACCHARIDE, RECOGNITION, ACTIVATION, INNATE

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MLA
Han, Biao, et al. “Structure-Functional Activity Relationship of β-Glucans from the Perspective of Immunomodulation : A Mini-Review.” FRONTIERS IN IMMUNOLOGY, vol. 11, 2020, doi:10.3389/fimmu.2020.00658.
APA
Han, B., Baruah, S. K., Cox, E., Vanrompay, D., & Bossier, P. (2020). Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review. FRONTIERS IN IMMUNOLOGY, 11. https://doi.org/10.3389/fimmu.2020.00658
Chicago author-date
Han, Biao, Sri Kartik Baruah, Eric Cox, Daisy Vanrompay, and Peter Bossier. 2020. “Structure-Functional Activity Relationship of β-Glucans from the Perspective of Immunomodulation : A Mini-Review.” FRONTIERS IN IMMUNOLOGY 11. https://doi.org/10.3389/fimmu.2020.00658.
Chicago author-date (all authors)
Han, Biao, Sri Kartik Baruah, Eric Cox, Daisy Vanrompay, and Peter Bossier. 2020. “Structure-Functional Activity Relationship of β-Glucans from the Perspective of Immunomodulation : A Mini-Review.” FRONTIERS IN IMMUNOLOGY 11. doi:10.3389/fimmu.2020.00658.
Vancouver
1.
Han B, Baruah SK, Cox E, Vanrompay D, Bossier P. Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review. FRONTIERS IN IMMUNOLOGY. 2020;11.
IEEE
[1]
B. Han, S. K. Baruah, E. Cox, D. Vanrompay, and P. Bossier, “Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review,” FRONTIERS IN IMMUNOLOGY, vol. 11, 2020.
@article{8660025,
  abstract     = {β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths. β-Glucans initiate immune responses via immune cells, which become activated by the binding of the polymer to specific receptors. However, β-glucans from different sources also differ in their structure, conformation, physical properties, binding affinity to receptors, and thus biological functions. The mechanisms behind this are not fully understood. This mini-review provides a comprehensive and up-to-date commentary on the relationship between β-glucans' structure and function in relation to their use for immunomodulation.},
  articleno    = {658},
  author       = {Han, Biao and Baruah, Sri Kartik and Cox, Eric and Vanrompay, Daisy and Bossier, Peter},
  issn         = {1664-3224},
  journal      = {FRONTIERS IN IMMUNOLOGY},
  keywords     = {beta-glucans,structure-function relationship,immunomodulation,molecular structure,molecular weight,solubility,MOLECULAR-WEIGHT,ANTITUMOR-ACTIVITY,IMMUNOSTIMULATORY ACTIVITY,BIOLOGICAL-ACTIVITIES,IMMUNE-RESPONSES,CELL-WALLS,POLYSACCHARIDE,RECOGNITION,ACTIVATION,INNATE},
  language     = {eng},
  pages        = {8},
  title        = {Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review},
  url          = {http://dx.doi.org/10.3389/fimmu.2020.00658},
  volume       = {11},
  year         = {2020},
}

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