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Superficial mycoses in Belgium : burden, costs and antifungal drugs consumption

(2020) MYCOSES. 63(5). p.500-508
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Organization
Abstract
Background. Monitoring of superficial mycoses requires more attention due to their important incidence, health costs and antifungal drugs consumption. Objectives. The objectives were to estimate the burden of superficial mycoses in Belgium and to assess trends in associated antifungal consumption. Methods. The burden of dermatophytoses (including onychomycosis), as well as skin and genital candidiasis, was estimated using disability‐adjusted life years (DALY). Moreover, trends in systemic and topical antifungal consumption in ambulatory care were examined for the period 2010‐2017, together with their associated costs. Results. Due to their high incidence and long treatment duration, dermatophytoses represented the bulk of the burden, accounting for 92.2% of the total DALYs of superficial mycoses. Terbinafine was the most prescribed antifungal in terms of doses (35.4% of the total doses) while fluconazole was the most delivered drug in terms of packages (29.1% of the total packages). More than 70% of the prescriptions were made by general practitioners while consumption varied according to age and gender of the patients. A global 12% decrease in antifungal prescriptions was observed between 2011 and 2017. However, this reduction would result mainly from packaging changes and increased self‐medication. A significant decrease in itraconazole treatments was notably compensated by an increased prescription of fluconazole packages. Conclusion. This study emphasises that dermatological presentations of superficial mycoses are the most important in terms of both burden and antifungal consumption in Belgium. Further reduction in antifungals use can be achieved by applying the adequate treatment after identification of the causative agent.
Keywords
Infectious Diseases, Dermatology, General Medicine, antifungal drugs consumption, Belgium, burden, candidiasis, cost, dermatophytosis, disability-adjusted life years, superficial mycosis, GLOBAL BURDEN, FUNGAL-INFECTIONS, PREVALENCE, DISABILITY, COUNTRIES, DISEASES, EUROPE

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MLA
Becker, Pierre, et al. “Superficial Mycoses in Belgium : Burden, Costs and Antifungal Drugs Consumption.” MYCOSES, vol. 63, no. 5, 2020, pp. 500–08, doi:10.1111/myc.13063.
APA
Becker, P., Lecerf, P., Claereboudt, J., Devleesschauwer, B., Packeu, A., & Hendrickx, M. (2020). Superficial mycoses in Belgium : burden, costs and antifungal drugs consumption. MYCOSES, 63(5), 500–508. https://doi.org/10.1111/myc.13063
Chicago author-date
Becker, Pierre, Pauline Lecerf, Julie Claereboudt, Brecht Devleesschauwer, Ann Packeu, and Marijke Hendrickx. 2020. “Superficial Mycoses in Belgium : Burden, Costs and Antifungal Drugs Consumption.” MYCOSES 63 (5): 500–508. https://doi.org/10.1111/myc.13063.
Chicago author-date (all authors)
Becker, Pierre, Pauline Lecerf, Julie Claereboudt, Brecht Devleesschauwer, Ann Packeu, and Marijke Hendrickx. 2020. “Superficial Mycoses in Belgium : Burden, Costs and Antifungal Drugs Consumption.” MYCOSES 63 (5): 500–508. doi:10.1111/myc.13063.
Vancouver
1.
Becker P, Lecerf P, Claereboudt J, Devleesschauwer B, Packeu A, Hendrickx M. Superficial mycoses in Belgium : burden, costs and antifungal drugs consumption. MYCOSES. 2020;63(5):500–8.
IEEE
[1]
P. Becker, P. Lecerf, J. Claereboudt, B. Devleesschauwer, A. Packeu, and M. Hendrickx, “Superficial mycoses in Belgium : burden, costs and antifungal drugs consumption,” MYCOSES, vol. 63, no. 5, pp. 500–508, 2020.
@article{8659625,
  abstract     = {{Background. Monitoring of superficial mycoses requires more attention due to their important incidence, health costs and antifungal drugs consumption.

Objectives. The objectives were to estimate the burden of superficial mycoses in Belgium and to assess trends in associated antifungal consumption.

Methods. The burden of dermatophytoses (including onychomycosis), as well as skin and genital candidiasis, was estimated using disability‐adjusted life years (DALY). Moreover, trends in systemic and topical antifungal consumption in ambulatory care were examined for the period 2010‐2017, together with their associated costs.

Results. Due to their high incidence and long treatment duration, dermatophytoses represented the bulk of the burden, accounting for 92.2% of the total DALYs of superficial mycoses. Terbinafine was the most prescribed antifungal in terms of doses (35.4% of the total doses) while fluconazole was the most delivered drug in terms of packages (29.1% of the total packages). More than 70% of the prescriptions were made by general practitioners while consumption varied according to age and gender of the patients. A global 12% decrease in antifungal prescriptions was observed between 2011 and 2017. However, this reduction would result mainly from packaging changes and increased self‐medication. A significant decrease in itraconazole treatments was notably compensated by an increased prescription of fluconazole packages.

Conclusion. This study emphasises that dermatological presentations of superficial mycoses are the most important in terms of both burden and antifungal consumption in Belgium. Further reduction in antifungals use can be achieved by applying the adequate treatment after identification of the causative agent.}},
  author       = {{Becker, Pierre and Lecerf, Pauline and Claereboudt, Julie and Devleesschauwer, Brecht and Packeu, Ann and Hendrickx, Marijke}},
  issn         = {{0933-7407}},
  journal      = {{MYCOSES}},
  keywords     = {{Infectious Diseases,Dermatology,General Medicine,antifungal drugs consumption,Belgium,burden,candidiasis,cost,dermatophytosis,disability-adjusted life years,superficial mycosis,GLOBAL BURDEN,FUNGAL-INFECTIONS,PREVALENCE,DISABILITY,COUNTRIES,DISEASES,EUROPE}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{500--508}},
  title        = {{Superficial mycoses in Belgium : burden, costs and antifungal drugs consumption}},
  url          = {{http://doi.org/10.1111/myc.13063}},
  volume       = {{63}},
  year         = {{2020}},
}

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