@article{8659009,
  abstract     = {{Intrauterine infection and inflammation remain a major cause of preterm labour in women and mares, with little known about small RNA (sRNA) expression in tissue or circulation. To better characterise placental inflammation (placentitis), we examined sRNA expression in the endometrium, chorioallantois and serum of mares with and without placentitis. Disease was induced in 10 mares via intracervical inoculation of Streptococcus equi ssp. zooepidemicus, either with moderate or high levels of inoculum; three uninoculated gestationally matched mares were used as controls. Matched chorioallantois and endometrium were sampled in two locations: Region 1, gross inflammation near cervical star with placental separation and Region 2, gross inflammation without placental separation. In Region 1, 26 sRNAs were altered in chorioallantois, while 20 were altered in endometrium. Within Region 2, changes were more subdued in both chorioallantois (10 sRNAs) and endometrium (two sRNAs). Within serum, we identified nine significantly altered sRNAs. In summary, we have characterised the expression of sRNA in the chorioallantois, the endometrium and the serum of mares with experimentally induced placentitis using next-generation sequencing, identifying significant changes within each tissue examined. These data should provide valuable information about the physiology of placental inflammation to clinicians and researchers alike.}},
  articleno    = {{1144}},
  author       = {{Loux, Shavahn C. and Fernandes, Claudia B. and Dini, Pouya and Wang, Kai and Wu, Xiaogang and Baxter, David and Scoggin, Kirsten E. and Troedsson, Mats H. T. and Squires, Edward L. and Ball, Barry A.}},
  issn         = {{1031-3613}},
  journal      = {{REPRODUCTION FERTILITY AND DEVELOPMENT}},
  keywords     = {{Biotechnology,Developmental Biology,Animal Science and Zoology,Genetics,Molecular Biology,Endocrinology,Reproductive Medicine,EXTRACELLULAR VESICLES,ASCENDING PLACENTITIS,SIGNALING PATHWAY,PRETERM DELIVERY,MICRORNAS,PREGNANCY,EXOSOMES,PROTEIN,MIR-17-SIMILAR-TO-92,INFLAMMATION,infection,inflammation,microRNA,placenta,pregnancy}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1144:1144--1144:1156}},
  title        = {{Small RNA (sRNA) expression in the chorioallantois, endometrium and serum of mares following experimental induction of placentitis}},
  url          = {{http://doi.org/10.1071/rd18400}},
  volume       = {{31}},
  year         = {{2019}},
}

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