Advanced search
1 file | 354.12 KB Add to list

Foci of segmentally contracted sarcomeres in trapezius muscle biopsy specimens in myalgic and nonmyalgic human subjects : preliminary results

(2020) PAIN MEDICINE. 21(10). p.2348-2356
Author
Organization
Abstract
Objective The myofascial trigger point hypothesis postulates that there are small foci of contracted sarcomeres in resting skeletal muscle. Only one example, in canine muscle, has been published previously. This study evaluated human muscle biopsies for foci of contracted sarcomeres. Setting The Departments of Rehabilitation Sciences and Physiotherapy at Ghent University, Ghent, Belgium. Subjects Biopsies from 28 women with or without trapezius myalgia were evaluated, 14 in each group. Methods Muscle biopsies were obtained from regions of taut bands in the trapezius muscle and processed for light and electron microscopy and for histochemical analysis. Examination of the biopsies was blinded as to group. Results A small number of foci of segmentally contracted sarcomeres were identified. One fusiform segmental locus involved the entire muscle fiber in tissue from a myalgic subject. Several transition zones from normal to contracted sarcomeres were found in both myalgic and nonmyalgic subjects. The distance between Z-lines in contracted sarcomeres was about 25–45% of the same distance in normal sarcomeres. Z-lines were disrupted and smeared in the contracted sarcomeres. Conclusions A small number of foci of segmentally contracted sarcomeres were found in relaxed trapezius muscle in human subjects, a confirmation of the only other example of spontaneous segmental contraction of sarcomeres (in a canine muscle specimen), consistent with the hypothesis of trigger point formation and with the presence of trigger point end plate noise.
Keywords
Myofascial Trigger Points, Segmental Sarcomere Contraction, Taut Bands, Muscle Biopsy, Trigger Point Hypothesis, SPONTANEOUS ELECTRICAL-ACTIVITY, MYOFASCIAL TRIGGER POINTS, SKELETAL-MUSCLE, LESIONS

Downloads

  • (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 354.12 KB

Citation

Please use this url to cite or link to this publication:

MLA
Gerwin, Robert D., et al. “Foci of Segmentally Contracted Sarcomeres in Trapezius Muscle Biopsy Specimens in Myalgic and Nonmyalgic Human Subjects : Preliminary Results.” PAIN MEDICINE, vol. 21, no. 10, 2020, pp. 2348–56, doi:10.1093/pm/pnaa019.
APA
Gerwin, R. D., Cagnie, B., Petrovic, M., Van Dorpe, J., Calders, P., & De Meulemeester, K. (2020). Foci of segmentally contracted sarcomeres in trapezius muscle biopsy specimens in myalgic and nonmyalgic human subjects : preliminary results. PAIN MEDICINE, 21(10), 2348–2356. https://doi.org/10.1093/pm/pnaa019
Chicago author-date
Gerwin, Robert D., Barbara Cagnie, Mirko Petrovic, Jo Van Dorpe, Patrick Calders, and Kayleigh De Meulemeester. 2020. “Foci of Segmentally Contracted Sarcomeres in Trapezius Muscle Biopsy Specimens in Myalgic and Nonmyalgic Human Subjects : Preliminary Results.” PAIN MEDICINE 21 (10): 2348–56. https://doi.org/10.1093/pm/pnaa019.
Chicago author-date (all authors)
Gerwin, Robert D., Barbara Cagnie, Mirko Petrovic, Jo Van Dorpe, Patrick Calders, and Kayleigh De Meulemeester. 2020. “Foci of Segmentally Contracted Sarcomeres in Trapezius Muscle Biopsy Specimens in Myalgic and Nonmyalgic Human Subjects : Preliminary Results.” PAIN MEDICINE 21 (10): 2348–2356. doi:10.1093/pm/pnaa019.
Vancouver
1.
Gerwin RD, Cagnie B, Petrovic M, Van Dorpe J, Calders P, De Meulemeester K. Foci of segmentally contracted sarcomeres in trapezius muscle biopsy specimens in myalgic and nonmyalgic human subjects : preliminary results. PAIN MEDICINE. 2020;21(10):2348–56.
IEEE
[1]
R. D. Gerwin, B. Cagnie, M. Petrovic, J. Van Dorpe, P. Calders, and K. De Meulemeester, “Foci of segmentally contracted sarcomeres in trapezius muscle biopsy specimens in myalgic and nonmyalgic human subjects : preliminary results,” PAIN MEDICINE, vol. 21, no. 10, pp. 2348–2356, 2020.
@article{8658850,
  abstract     = {{Objective
The myofascial trigger point hypothesis postulates that there are small foci of contracted sarcomeres in resting skeletal muscle. Only one example, in canine muscle, has been published previously. This study evaluated human muscle biopsies for foci of contracted sarcomeres.
Setting
The Departments of Rehabilitation Sciences and Physiotherapy at Ghent University, Ghent, Belgium.
Subjects
Biopsies from 28 women with or without trapezius myalgia were evaluated, 14 in each group.
Methods
Muscle biopsies were obtained from regions of taut bands in the trapezius muscle and processed for light and electron microscopy and for histochemical analysis. Examination of the biopsies was blinded as to group.
Results
A small number of foci of segmentally contracted sarcomeres were identified. One fusiform segmental locus involved the entire muscle fiber in tissue from a myalgic subject. Several transition zones from normal to contracted sarcomeres were found in both myalgic and nonmyalgic subjects. The distance between Z-lines in contracted sarcomeres was about 25–45% of the same distance in normal sarcomeres. Z-lines were disrupted and smeared in the contracted sarcomeres.
Conclusions
A small number of foci of segmentally contracted sarcomeres were found in relaxed trapezius muscle in human subjects, a confirmation of the only other example of spontaneous segmental contraction of sarcomeres (in a canine muscle specimen), consistent with the hypothesis of trigger point formation and with the presence of trigger point end plate noise.}},
  author       = {{Gerwin, Robert D. and Cagnie, Barbara and Petrovic, Mirko and Van Dorpe, Jo and Calders, Patrick and De Meulemeester, Kayleigh}},
  issn         = {{1526-2375}},
  journal      = {{PAIN MEDICINE}},
  keywords     = {{Myofascial Trigger Points,Segmental Sarcomere Contraction,Taut Bands,Muscle Biopsy,Trigger Point Hypothesis,SPONTANEOUS ELECTRICAL-ACTIVITY,MYOFASCIAL TRIGGER POINTS,SKELETAL-MUSCLE,LESIONS}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{2348--2356}},
  title        = {{Foci of segmentally contracted sarcomeres in trapezius muscle biopsy specimens in myalgic and nonmyalgic human subjects : preliminary results}},
  url          = {{http://dx.doi.org/10.1093/pm/pnaa019}},
  volume       = {{21}},
  year         = {{2020}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: