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FRS7 and FRS12 recruit NINJA to regulate expression of glucosinolate biosynthesis genes

Patricia Fernandez Calvo (UGent) , Sabrina Iñigo (UGent) , Gaétan Glauser, Robin Vanden Bossche (UGent) , Michelle Tang, Baohua Li, Rebecca De Clercq (UGent) , Astrid Nagels Durand (UGent) , Dominique Eeckhout (UGent) , Kris Gevaert (UGent) , et al.
(2020) NEW PHYTOLOGIST. 227(4). p.1124-1137
Author
Organization
Abstract
The sessile lifestyle of plants requires accurate physiology adjustments to be able to thrive in a changing environment. Plants integrate environmental timing signals to control developmental and stress responses. Here, we identified Far1 Related Sequence (FRS) 7 and FRS12, two transcriptional repressors that accumulate in short-day conditions, as regulators of Arabidopsis glucosinolate (GSL) biosynthesis. Loss of function of FRS7 and FRS12 results in plants with increased amplitudes of diurnal expression of GSL pathway genes. Protein interaction analyses revealed that FRS7 and FRS12 recruit the NOVEL INTERACTOR OF JAZ (NINJA) to assemble a transcriptional repressor complex. Genetic and molecular evidence demonstrated that FRS7, FRS12 and NINJA jointly regulate the expression of GSL biosynthetic genes, and thus constitute a molecular mechanism that modulates specialized metabolite accumulation.
Keywords
Glucosinolate, circadian, defense, diurnal, immune responses, jasmonate, light, rhythms, BHLH TRANSCRIPTION FACTORS, CIRCADIAN CLOCK, JAZ REPRESSORS, SIGNAL-TRANSDUCTION, STRESS-RESPONSE, ARABIDOPSIS, DEFENSE, GROWTH, PERCEPTION, MECHANISMS

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Citation

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MLA
Fernandez Calvo, Patricia, et al. “FRS7 and FRS12 Recruit NINJA to Regulate Expression of Glucosinolate Biosynthesis Genes.” NEW PHYTOLOGIST, vol. 227, no. 4, 2020, pp. 1124–37, doi:10.1111/nph.16586.
APA
Fernandez Calvo, P., Iñigo, S., Glauser, G., Vanden Bossche, R., Tang, M., Li, B., … Ritter Traub, A. (2020). FRS7 and FRS12 recruit NINJA to regulate expression of glucosinolate biosynthesis genes. NEW PHYTOLOGIST, 227(4), 1124–1137. https://doi.org/10.1111/nph.16586
Chicago author-date
Fernandez Calvo, Patricia, Sabrina Iñigo, Gaétan Glauser, Robin Vanden Bossche, Michelle Tang, Baohua Li, Rebecca De Clercq, et al. 2020. “FRS7 and FRS12 Recruit NINJA to Regulate Expression of Glucosinolate Biosynthesis Genes.” NEW PHYTOLOGIST 227 (4): 1124–37. https://doi.org/10.1111/nph.16586.
Chicago author-date (all authors)
Fernandez Calvo, Patricia, Sabrina Iñigo, Gaétan Glauser, Robin Vanden Bossche, Michelle Tang, Baohua Li, Rebecca De Clercq, Astrid Nagels Durand, Dominique Eeckhout, Kris Gevaert, Geert De Jaeger, Siobhan M. Brady, Daniel J. Kliebenstein, Laurens Pauwels, Alain Goossens, and Andrés Ritter Traub. 2020. “FRS7 and FRS12 Recruit NINJA to Regulate Expression of Glucosinolate Biosynthesis Genes.” NEW PHYTOLOGIST 227 (4): 1124–1137. doi:10.1111/nph.16586.
Vancouver
1.
Fernandez Calvo P, Iñigo S, Glauser G, Vanden Bossche R, Tang M, Li B, et al. FRS7 and FRS12 recruit NINJA to regulate expression of glucosinolate biosynthesis genes. NEW PHYTOLOGIST. 2020;227(4):1124–37.
IEEE
[1]
P. Fernandez Calvo et al., “FRS7 and FRS12 recruit NINJA to regulate expression of glucosinolate biosynthesis genes,” NEW PHYTOLOGIST, vol. 227, no. 4, pp. 1124–1137, 2020.
@article{8658790,
  abstract     = {{The sessile lifestyle of plants requires accurate physiology adjustments to be able to thrive in a changing environment. Plants integrate environmental timing signals to control developmental and stress responses. Here, we identified Far1 Related Sequence (FRS) 7 and FRS12, two transcriptional repressors that accumulate in short-day conditions, as regulators of Arabidopsis glucosinolate (GSL) biosynthesis. Loss of function of FRS7 and FRS12 results in plants with increased amplitudes of diurnal expression of GSL pathway genes. Protein interaction analyses revealed that FRS7 and FRS12 recruit the NOVEL INTERACTOR OF JAZ (NINJA) to assemble a transcriptional repressor complex. Genetic and molecular evidence demonstrated that FRS7, FRS12 and NINJA jointly regulate the expression of GSL biosynthetic genes, and thus constitute a molecular mechanism that modulates specialized metabolite accumulation.}},
  author       = {{Fernandez Calvo, Patricia and Iñigo, Sabrina and Glauser, Gaétan and Vanden Bossche, Robin and Tang, Michelle and Li, Baohua and De Clercq, Rebecca and Nagels Durand, Astrid and Eeckhout, Dominique and Gevaert, Kris and De Jaeger, Geert and Brady, Siobhan M. and Kliebenstein, Daniel J. and Pauwels, Laurens and Goossens, Alain and Ritter Traub, Andrés}},
  issn         = {{0028-646X}},
  journal      = {{NEW PHYTOLOGIST}},
  keywords     = {{Glucosinolate,circadian,defense,diurnal,immune responses,jasmonate,light,rhythms,BHLH TRANSCRIPTION FACTORS,CIRCADIAN CLOCK,JAZ REPRESSORS,SIGNAL-TRANSDUCTION,STRESS-RESPONSE,ARABIDOPSIS,DEFENSE,GROWTH,PERCEPTION,MECHANISMS}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1124--1137}},
  title        = {{FRS7 and FRS12 recruit NINJA to regulate expression of glucosinolate biosynthesis genes}},
  url          = {{http://doi.org/10.1111/nph.16586}},
  volume       = {{227}},
  year         = {{2020}},
}
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