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Virus-host coexistence in phytoplankton through the genomic lens

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Abstract
Virus-microbe interactions in the ocean are commonly described by "boom and bust" dynamics, whereby a numerically dominant microorganism is lysed and replaced by a virus-resistant one. Here, we isolated a microalga strain and its infective dsDNA virus whose dynamics are characterized instead by parallel growth of both the microalga and the virus. Experimental evolution of clonal lines revealed that this viral production originates from the lysis of a minority of virus-susceptible cells, which are regenerated from resistant cells. Whole-genome sequencing demonstrated that this resistant-susceptible switch involved a large deletion on one chromosome. Mathematical modeling explained how the switch maintains stable microalga-virus population dynamics consistent with their observed growth pattern. Comparative genomics confirmed an ancient origin of this "accordion" chromosome despite a lack of sequence conservation. Together, our results show how dynamic genomic rearrangements may account for a previously overlooked coexistence mechanism in microalgae-virus interactions.
Keywords
OSTREOCOCCUS-TAURI, QUANTITATIVE PCR, MARINE, RESISTANCE, ACQUISITION, DIVERSITY, EUKARYOTE, DYNAMICS, SEQUENCE, MODE

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Citation

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MLA
Yau, Sheree, et al. “Virus-Host Coexistence in Phytoplankton through the Genomic Lens.” SCIENCE ADVANCES, vol. 6, no. 14, 2020.
APA
Yau, S., Krasovec, M., Benites, L. F., Rombauts, S., Groussin, M., Vancaester, E., … Piganeau, G. (2020). Virus-host coexistence in phytoplankton through the genomic lens. SCIENCE ADVANCES, 6(14).
Chicago author-date
Yau, Sheree, Marc Krasovec, L. Felipe Benites, Stephane Rombauts, Mathieu Groussin, Emmelien Vancaester, Jean-Marc Aury, et al. 2020. “Virus-Host Coexistence in Phytoplankton through the Genomic Lens.” SCIENCE ADVANCES 6 (14).
Chicago author-date (all authors)
Yau, Sheree, Marc Krasovec, L. Felipe Benites, Stephane Rombauts, Mathieu Groussin, Emmelien Vancaester, Jean-Marc Aury, Evelyne Derelle, Yves Desdevises, Marie-Line Escande, Nigel Grimsley, Julie Guy, Herve Moreau, Sophie Sanchez-Brosseau, Yves Van de Peer, Klaas Vandepoele, Sebastien Gourbiere, and Gwenael Piganeau. 2020. “Virus-Host Coexistence in Phytoplankton through the Genomic Lens.” SCIENCE ADVANCES 6 (14).
Vancouver
1.
Yau S, Krasovec M, Benites LF, Rombauts S, Groussin M, Vancaester E, et al. Virus-host coexistence in phytoplankton through the genomic lens. SCIENCE ADVANCES. 2020;6(14).
IEEE
[1]
S. Yau et al., “Virus-host coexistence in phytoplankton through the genomic lens,” SCIENCE ADVANCES, vol. 6, no. 14, 2020.
@article{8658785,
  abstract     = {Virus-microbe interactions in the ocean are commonly described by "boom and bust" dynamics, whereby a numerically dominant microorganism is lysed and replaced by a virus-resistant one. Here, we isolated a microalga strain and its infective dsDNA virus whose dynamics are characterized instead by parallel growth of both the microalga and the virus. Experimental evolution of clonal lines revealed that this viral production originates from the lysis of a minority of virus-susceptible cells, which are regenerated from resistant cells. Whole-genome sequencing demonstrated that this resistant-susceptible switch involved a large deletion on one chromosome. Mathematical modeling explained how the switch maintains stable microalga-virus population dynamics consistent with their observed growth pattern. Comparative genomics confirmed an ancient origin of this "accordion" chromosome despite a lack of sequence conservation. Together, our results show how dynamic genomic rearrangements may account for a previously overlooked coexistence mechanism in microalgae-virus interactions.},
  articleno    = {eaay2587},
  author       = {Yau, Sheree and Krasovec, Marc and Benites, L. Felipe and Rombauts, Stephane and Groussin, Mathieu and Vancaester, Emmelien and Aury, Jean-Marc and Derelle, Evelyne and Desdevises, Yves and Escande, Marie-Line and Grimsley, Nigel and Guy, Julie and Moreau, Herve and Sanchez-Brosseau, Sophie and Van de Peer, Yves and Vandepoele, Klaas and Gourbiere, Sebastien and Piganeau, Gwenael},
  issn         = {2375-2548},
  journal      = {SCIENCE ADVANCES},
  keywords     = {OSTREOCOCCUS-TAURI,QUANTITATIVE PCR,MARINE,RESISTANCE,ACQUISITION,DIVERSITY,EUKARYOTE,DYNAMICS,SEQUENCE,MODE},
  language     = {eng},
  number       = {14},
  pages        = {12},
  title        = {Virus-host coexistence in phytoplankton through the genomic lens},
  url          = {http://dx.doi.org/10.1126/sciadv.aay2587},
  volume       = {6},
  year         = {2020},
}

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