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Influence of side-chain length on long-term release kinetics from poly(2-oxazoline)-drug conjugate networks

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Abstract
Four drug-conjugated poly(2-alkyl-2-oxazoline) (PAOx) networks with different hydrophobicity were synthesized via copolymerization of either 2-methyl-, 2-ethyl-, 2-propyl- or 2-butyl-2-oxazoline with the functional monomer, 2-dec-9-enyl-2-oxazoline. The incorporation of a labile ester linkage between the polymer and the drug benazepril allowed for sustained drug release over periods of months with the release rates strongly depending on the hydrophobicity of the polymer pendant groups. Drug loading of 13 +/- 2 wt% was used with 10 mol% crosslinking sites simply by tuning the thiol-ene stoichiometry. The networks exhibited negligible cell toxicity but cell repulsion was observed for hydrogels based on poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline) while those based on poly(2-n-propyl-2-oxazoline) and poly(2-n-butyl-2-oxaoline) showed cell adhesion. These results suggest that PAOx networks have great potential as drug delivery devices for long-lasting drug release applications.
Keywords
DRUG-RELEASE, DELIVERY, HYDROGELS, POLY(2-ETHYL-2-OXAZOLINE), POLYMERIZATION, THERAPY, BEHAVIOR, CANCER, SKIN, Benazepril, Drug conjugation, Drug delivery, Hydrogel, Poly(2-oxazoline)

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MLA
Park, Jong-Ryul, et al. “Influence of Side-Chain Length on Long-Term Release Kinetics from Poly(2-Oxazoline)-Drug Conjugate Networks.” EUROPEAN POLYMER JOURNAL, vol. 120, 2019.
APA
Park, J.-R., Van Guyse, J., Podevyn, A., Bolle, E. C. L., Bock, N., Linde, E., … Dargaville, T. R. (2019). Influence of side-chain length on long-term release kinetics from poly(2-oxazoline)-drug conjugate networks. EUROPEAN POLYMER JOURNAL, 120.
Chicago author-date
Park, Jong-Ryul, Joachim Van Guyse, Annelore Podevyn, Eleonore C. L. Bolle, Nathalie Bock, Erik Linde, Mathew Celina, Richard Hoogenboom, and Tim R. Dargaville. 2019. “Influence of Side-Chain Length on Long-Term Release Kinetics from Poly(2-Oxazoline)-Drug Conjugate Networks.” EUROPEAN POLYMER JOURNAL 120.
Chicago author-date (all authors)
Park, Jong-Ryul, Joachim Van Guyse, Annelore Podevyn, Eleonore C. L. Bolle, Nathalie Bock, Erik Linde, Mathew Celina, Richard Hoogenboom, and Tim R. Dargaville. 2019. “Influence of Side-Chain Length on Long-Term Release Kinetics from Poly(2-Oxazoline)-Drug Conjugate Networks.” EUROPEAN POLYMER JOURNAL 120.
Vancouver
1.
Park J-R, Van Guyse J, Podevyn A, Bolle ECL, Bock N, Linde E, et al. Influence of side-chain length on long-term release kinetics from poly(2-oxazoline)-drug conjugate networks. EUROPEAN POLYMER JOURNAL. 2019;120.
IEEE
[1]
J.-R. Park et al., “Influence of side-chain length on long-term release kinetics from poly(2-oxazoline)-drug conjugate networks,” EUROPEAN POLYMER JOURNAL, vol. 120, 2019.
@article{8658220,
  abstract     = {Four drug-conjugated poly(2-alkyl-2-oxazoline) (PAOx) networks with different hydrophobicity were synthesized via copolymerization of either 2-methyl-, 2-ethyl-, 2-propyl- or 2-butyl-2-oxazoline with the functional monomer, 2-dec-9-enyl-2-oxazoline. The incorporation of a labile ester linkage between the polymer and the drug benazepril allowed for sustained drug release over periods of months with the release rates strongly depending on the hydrophobicity of the polymer pendant groups. Drug loading of 13 +/- 2 wt% was used with 10 mol% crosslinking sites simply by tuning the thiol-ene stoichiometry. The networks exhibited negligible cell toxicity but cell repulsion was observed for hydrogels based on poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline) while those based on poly(2-n-propyl-2-oxazoline) and poly(2-n-butyl-2-oxaoline) showed cell adhesion. These results suggest that PAOx networks have great potential as drug delivery devices for long-lasting drug release applications.},
  articleno    = {109217},
  author       = {Park, Jong-Ryul and Van Guyse, Joachim and Podevyn, Annelore and Bolle, Eleonore C. L. and Bock, Nathalie and Linde, Erik and Celina, Mathew and Hoogenboom, Richard and Dargaville, Tim R.},
  issn         = {0014-3057},
  journal      = {EUROPEAN POLYMER JOURNAL},
  keywords     = {DRUG-RELEASE,DELIVERY,HYDROGELS,POLY(2-ETHYL-2-OXAZOLINE),POLYMERIZATION,THERAPY,BEHAVIOR,CANCER,SKIN,Benazepril,Drug conjugation,Drug delivery,Hydrogel,Poly(2-oxazoline)},
  language     = {eng},
  pages        = {9},
  title        = {Influence of side-chain length on long-term release kinetics from poly(2-oxazoline)-drug conjugate networks},
  url          = {http://dx.doi.org/10.1016/j.eurpolymj.2019.109217},
  volume       = {120},
  year         = {2019},
}

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