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Human T cell glycosylation and implications on immune therapy for cancer

Elien De Bousser (UGent) , Leander Meuris (UGent) , Nico Callewaert (UGent) and Nele Festjens (UGent)
(2020) Human Vaccines & Immunotherapeutics.
Author
Organization
Abstract
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome. When focusing on immunity, glycans are indispensable in virtually all signaling and cell-cell interactions. More specifically, glycans have been shown to regulate key pathophysiological steps within T cell biology such as T cell development, thymocyte selection, T cell activity and signaling as well as T cell differentiation and proliferation. They are of major importance in determining the interaction of human T cells with tumor cells. In this review, we will describe the role of glycosylation of human T cells in more depth, elaborate on the importance of glycosylation in the interaction of human T cells with tumor cells and discuss the potential of cancer immunotherapies that are based on manipulating the glycome functions at the tumor immune interface.
Keywords
Immunology, Immunology and Allergy, Pharmacology

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Citation

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MLA
De Bousser, Elien, et al. “Human T Cell Glycosylation and Implications on Immune Therapy for Cancer.” Human Vaccines & Immunotherapeutics, TAYLOR & FRANCIS INC, 2020, doi:10.1080/21645515.2020.1730658.
APA
De Bousser, E., Meuris, L., Callewaert, N., & Festjens, N. (2020). Human T cell glycosylation and implications on immune therapy for cancer. Human Vaccines & Immunotherapeutics. https://doi.org/10.1080/21645515.2020.1730658
Chicago author-date
De Bousser, Elien, Leander Meuris, Nico Callewaert, and Nele Festjens. 2020. “Human T Cell Glycosylation and Implications on Immune Therapy for Cancer.” Human Vaccines & Immunotherapeutics. https://doi.org/10.1080/21645515.2020.1730658.
Chicago author-date (all authors)
De Bousser, Elien, Leander Meuris, Nico Callewaert, and Nele Festjens. 2020. “Human T Cell Glycosylation and Implications on Immune Therapy for Cancer.” Human Vaccines & Immunotherapeutics. doi:10.1080/21645515.2020.1730658.
Vancouver
1.
De Bousser E, Meuris L, Callewaert N, Festjens N. Human T cell glycosylation and implications on immune therapy for cancer. Human Vaccines & Immunotherapeutics. 2020;
IEEE
[1]
E. De Bousser, L. Meuris, N. Callewaert, and N. Festjens, “Human T cell glycosylation and implications on immune therapy for cancer,” Human Vaccines & Immunotherapeutics, 2020.
@article{8655234,
  abstract     = {{Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome. When focusing on immunity, glycans are indispensable in virtually all signaling and cell-cell interactions. More specifically, glycans have been shown to regulate key pathophysiological steps within T cell biology such as T cell development, thymocyte selection, T cell activity and signaling as well as T cell differentiation and proliferation. They are of major importance in determining the interaction of human T cells with tumor cells. In this review, we will describe the role of glycosylation of human T cells in more depth, elaborate on the importance of glycosylation in the interaction of human T cells with tumor cells and discuss the potential of cancer immunotherapies that are based on manipulating the glycome functions at the tumor immune interface.}},
  author       = {{De Bousser, Elien and Meuris, Leander and Callewaert, Nico and Festjens, Nele}},
  issn         = {{2164-5515}},
  journal      = {{Human Vaccines & Immunotherapeutics}},
  keywords     = {{Immunology,Immunology and Allergy,Pharmacology}},
  language     = {{eng}},
  pages        = {{15}},
  publisher    = {{TAYLOR & FRANCIS INC}},
  title        = {{Human T cell glycosylation and implications on immune therapy for cancer}},
  url          = {{http://dx.doi.org/10.1080/21645515.2020.1730658}},
  year         = {{2020}},
}
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