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Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair

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Abstract
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.
Keywords
REGULATORY T-CELLS, HYPOXIA-INDUCIBLE FACTOR-1-ALPHA, ANTIBODY-MEDIATED, REJECTION, DELAYED GRAFT FUNCTION, MESENCHYMAL TRANSITION, RECEPTOR 4, IMMUNE-RESPONSES, DENDRITIC CELLS, INNATE IMMUNITY, IN-VIVO, ischemia reperfusion injury, kidney transplantation, delayed graft, function, innate immune system, adaptive immune system, apoptosis, necrosis, hypoxic inducible factor, endothelial dysfunction

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MLA
Nieuwenhuijs-Moeke, Gertrude J., et al. “Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair.” JOURNAL OF CLINICAL MEDICINE, vol. 9, no. 1, Mdpi, 2020.
APA
Nieuwenhuijs-Moeke, G. J., Pischke, S. E., Berger, S. P., Sanders, J. S. F., Pol, R. A., Struys, M., … Leuvenink, H. G. D. (2020). Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair. JOURNAL OF CLINICAL MEDICINE, 9(1).
Chicago author-date
Nieuwenhuijs-Moeke, Gertrude J., Soren E. Pischke, Stefan P. Berger, Jan Stephan F. Sanders, Robert A. Pol, Michel Struys, Rutger J. Ploeg, and Henri G. D. Leuvenink. 2020. “Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair.” JOURNAL OF CLINICAL MEDICINE 9 (1).
Chicago author-date (all authors)
Nieuwenhuijs-Moeke, Gertrude J., Soren E. Pischke, Stefan P. Berger, Jan Stephan F. Sanders, Robert A. Pol, Michel Struys, Rutger J. Ploeg, and Henri G. D. Leuvenink. 2020. “Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair.” JOURNAL OF CLINICAL MEDICINE 9 (1).
Vancouver
1.
Nieuwenhuijs-Moeke GJ, Pischke SE, Berger SP, Sanders JSF, Pol RA, Struys M, et al. Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair. JOURNAL OF CLINICAL MEDICINE. 2020;9(1).
IEEE
[1]
G. J. Nieuwenhuijs-Moeke et al., “Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair,” JOURNAL OF CLINICAL MEDICINE, vol. 9, no. 1, 2020.
@article{8655019,
  abstract     = {Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.},
  articleno    = {253},
  author       = {Nieuwenhuijs-Moeke, Gertrude J. and Pischke, Soren E. and Berger, Stefan P. and Sanders, Jan Stephan F. and Pol, Robert A. and Struys, Michel and Ploeg, Rutger J. and Leuvenink, Henri G. D.},
  issn         = {2077-0383},
  journal      = {JOURNAL OF CLINICAL MEDICINE},
  keywords     = {REGULATORY T-CELLS,HYPOXIA-INDUCIBLE FACTOR-1-ALPHA,ANTIBODY-MEDIATED,REJECTION,DELAYED GRAFT FUNCTION,MESENCHYMAL TRANSITION,RECEPTOR 4,IMMUNE-RESPONSES,DENDRITIC CELLS,INNATE IMMUNITY,IN-VIVO,ischemia reperfusion injury,kidney transplantation,delayed graft,function,innate immune system,adaptive immune system,apoptosis,necrosis,hypoxic inducible factor,endothelial dysfunction},
  language     = {eng},
  number       = {1},
  pages        = {33},
  publisher    = {Mdpi},
  title        = {Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair},
  url          = {http://dx.doi.org/10.3390/jcm9010253},
  volume       = {9},
  year         = {2020},
}

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