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Recent progress in continuous manufacturing of oral solid dosage forms

Valérie Vanhoorne (UGent) and Chris Vervaet (UGent)
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Abstract
Continuous drug product manufacturing is slowly being implemented in the pharmaceutical industry. Although the benefits related to the quality and cost of continuous manufacturing are widely recognized, several challenges hampered the widespread introduction of continuous manufacturing of drug products. Current review presents an overview of state-of-the art research, equipment, process analytical technology implementations and advanced control strategies. Additionally, guidelines and regulatory viewpoints on implementation of continuous manufacturing in the pharmaceutical industry are discussed.
Keywords
Continuous manufacturing, Twin-screw granulation, Roller compaction, Direct compression, Advanced process control, Process analytical technology, CONTINUOUS DIRECT COMPRESSION, NEAR-INFRARED SPECTROSCOPY, TWIN-SCREW GRANULATION, PROCESS ANALYTICAL TECHNOLOGY, CRITICAL QUALITY ATTRIBUTES, IN-LINE, WET GRANULATION, DRUG CONTENT, PHARMACEUTICAL TABLETS, ULTRASOUND MEASUREMENT

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MLA
Vanhoorne, Valérie, and Chris Vervaet. “Recent Progress in Continuous Manufacturing of Oral Solid Dosage Forms.” INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 579, 2020, doi:10.1016/j.ijpharm.2020.119194.
APA
Vanhoorne, V., & Vervaet, C. (2020). Recent progress in continuous manufacturing of oral solid dosage forms. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 579. https://doi.org/10.1016/j.ijpharm.2020.119194
Chicago author-date
Vanhoorne, Valérie, and Chris Vervaet. 2020. “Recent Progress in Continuous Manufacturing of Oral Solid Dosage Forms.” INTERNATIONAL JOURNAL OF PHARMACEUTICS 579. https://doi.org/10.1016/j.ijpharm.2020.119194.
Chicago author-date (all authors)
Vanhoorne, Valérie, and Chris Vervaet. 2020. “Recent Progress in Continuous Manufacturing of Oral Solid Dosage Forms.” INTERNATIONAL JOURNAL OF PHARMACEUTICS 579. doi:10.1016/j.ijpharm.2020.119194.
Vancouver
1.
Vanhoorne V, Vervaet C. Recent progress in continuous manufacturing of oral solid dosage forms. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2020;579.
IEEE
[1]
V. Vanhoorne and C. Vervaet, “Recent progress in continuous manufacturing of oral solid dosage forms,” INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 579, 2020.
@article{8654812,
  abstract     = {Continuous drug product manufacturing is slowly being implemented in the pharmaceutical industry. Although the benefits related to the quality and cost of continuous manufacturing are widely recognized, several challenges hampered the widespread introduction of continuous manufacturing of drug products. Current review presents an overview of state-of-the art research, equipment, process analytical technology implementations and advanced control strategies. Additionally, guidelines and regulatory viewpoints on implementation of continuous manufacturing in the pharmaceutical industry are discussed.},
  articleno    = {119194},
  author       = {Vanhoorne, Valérie and Vervaet, Chris},
  issn         = {0378-5173},
  journal      = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
  keywords     = {Continuous manufacturing,Twin-screw granulation,Roller compaction,Direct compression,Advanced process control,Process analytical technology,CONTINUOUS DIRECT COMPRESSION,NEAR-INFRARED SPECTROSCOPY,TWIN-SCREW GRANULATION,PROCESS ANALYTICAL TECHNOLOGY,CRITICAL QUALITY ATTRIBUTES,IN-LINE,WET GRANULATION,DRUG CONTENT,PHARMACEUTICAL TABLETS,ULTRASOUND MEASUREMENT},
  language     = {eng},
  pages        = {16},
  title        = {Recent progress in continuous manufacturing of oral solid dosage forms},
  url          = {http://dx.doi.org/10.1016/j.ijpharm.2020.119194},
  volume       = {579},
  year         = {2020},
}

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