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Targeting the tumor microenvironment in colorectal peritoneal metastases

(2020) TRENDS IN CANCER. 6(3). p.236-246
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Abstract
Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (IP) delivery of chemotherapy, is limited. Increasingly, therefore, efforts are being developed to unravel the PM cascade and at understanding the PM-associated tumor microenvironment (TME) and peritoneal ecosystem as potential therapeutic targets. Here, we review recent insights in the structure and components of the TME in colorectal PM, and discuss how these may translate into novel therapeutic approaches aimed at re-engineering the metastasis-promoting activity of the stroma.
Keywords
HUMAN MESOTHELIAL CELLS, CANCER-PATIENTS, COLON-CANCER, ADHESION MOLECULES, TGF-BETA, EXPRESSION, CARCINOMATOSIS, CHEMOTHERAPY, FIBROBLASTS, GROWTH

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MLA
Ceelen, Wim, et al. “Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases.” TRENDS IN CANCER, vol. 6, no. 3, 2020, pp. 236–46, doi:10.1016/j.trecan.2019.12.008.
APA
Ceelen, W., Ramsay, R. G., Narasimhan, V., Heriot, A. G., & De Wever, O. (2020). Targeting the tumor microenvironment in colorectal peritoneal metastases. TRENDS IN CANCER, 6(3), 236–246. https://doi.org/10.1016/j.trecan.2019.12.008
Chicago author-date
Ceelen, Wim, Robert G. Ramsay, Vignesh Narasimhan, Alexander G. Heriot, and Olivier De Wever. 2020. “Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases.” TRENDS IN CANCER 6 (3): 236–46. https://doi.org/10.1016/j.trecan.2019.12.008.
Chicago author-date (all authors)
Ceelen, Wim, Robert G. Ramsay, Vignesh Narasimhan, Alexander G. Heriot, and Olivier De Wever. 2020. “Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases.” TRENDS IN CANCER 6 (3): 236–246. doi:10.1016/j.trecan.2019.12.008.
Vancouver
1.
Ceelen W, Ramsay RG, Narasimhan V, Heriot AG, De Wever O. Targeting the tumor microenvironment in colorectal peritoneal metastases. TRENDS IN CANCER. 2020;6(3):236–46.
IEEE
[1]
W. Ceelen, R. G. Ramsay, V. Narasimhan, A. G. Heriot, and O. De Wever, “Targeting the tumor microenvironment in colorectal peritoneal metastases,” TRENDS IN CANCER, vol. 6, no. 3, pp. 236–246, 2020.
@article{8654250,
  abstract     = {Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (IP) delivery of chemotherapy, is limited. Increasingly, therefore, efforts are being developed to unravel the PM cascade and at understanding the PM-associated tumor microenvironment (TME) and peritoneal ecosystem as potential therapeutic targets. Here, we review recent insights in the structure and components of the TME in colorectal PM, and discuss how these may translate into novel therapeutic approaches aimed at re-engineering the metastasis-promoting activity of the stroma.},
  author       = {Ceelen, Wim and Ramsay, Robert G. and Narasimhan, Vignesh and Heriot, Alexander G. and De Wever, Olivier},
  issn         = {2405-8025},
  journal      = {TRENDS IN CANCER},
  keywords     = {HUMAN MESOTHELIAL CELLS,CANCER-PATIENTS,COLON-CANCER,ADHESION MOLECULES,TGF-BETA,EXPRESSION,CARCINOMATOSIS,CHEMOTHERAPY,FIBROBLASTS,GROWTH},
  language     = {eng},
  number       = {3},
  pages        = {236--246},
  title        = {Targeting the tumor microenvironment in colorectal peritoneal metastases},
  url          = {http://dx.doi.org/10.1016/j.trecan.2019.12.008},
  volume       = {6},
  year         = {2020},
}

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