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Impact of free-living pattern of sedentary behaviour on intra-day glucose regulation in type 2 diabetes

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Abstract
Purpose: To investigate how the pattern of sedentary behaviour affects intra-day glucose regulation in type 2 diabetes. Methods: This intensive longitudinal study was conducted in 37 participants with type 2 diabetes (age, 62.8 +/- 10.5 years). Glucose and sedentary behaviour/physical activity were assessed with a continuous glucose monitoring (Abbott FreeStyle Libre) and an activity monitor (activPAL3) for 14 days. Multiple regression models with generalised estimating equations (GEEs) approach were used to assess the associations of sedentary time and breaks in sedentary time with pre-breakfast glucose, pre-lunch glucose, pre-dinner glucose, post-breakfast glucose, post-lunch glucose, post-dinner glucose, bedtime glucose, the dawn phenomenon, time in target glucose range (TIR, glucose 3.9-10 mmol/L) and time above target glucose range (TAR, glucose > 10 mmol/L). Results: Sedentary time was associated with higher pre-breakfast glucose (p = 0.001), pre-dinner glucose (p < 0.001), post-lunch glucose (p = 0.005), post-dinner glucose (p = 0.013) and the dawn phenomenon (p < 0.001). Breaks in sedentary time were associated with lower pre-breakfast glucose (p = 0.023), pre-dinner glucose (p = 0.023), post-breakfast glucose (p < 0.001) and the dawn phenomenon (p = 0.004). The association between sedentary time and less TIR (p = 0.022) and the association between breaks in sedentary time and more TIR (p = 0.001) were also observed. Conclusions: Reducing sedentary time and promoting breaks in sedentary time could be clinically relevant to improve intra-day glucose regulation in type 2 diabetes.
Keywords
Type 2 diabetes, Glucose targets, Glycaemic control, Sedentary behaviour, Physical activity, Breaks in sedentary time, GLYCEMIC CONTROL, MICROVASCULAR COMPLICATIONS, PHYSICAL-ACTIVITY, DAWN PHENOMENON, TIME, ASSOCIATION, BREAKS, HYPERGLYCEMIA, DURATION, MODERATE

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MLA
Paing, Aye C., et al. “Impact of Free-Living Pattern of Sedentary Behaviour on Intra-Day Glucose Regulation in Type 2 Diabetes.” EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, vol. 120, no. 1, 2019, pp. 171–79.
APA
Paing, A. C., McMillan, K. A., Kirk, A. F., Collier, A., Hewitt, A., & Chastin, S. (2019). Impact of free-living pattern of sedentary behaviour on intra-day glucose regulation in type 2 diabetes. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 120(1), 171–179.
Chicago author-date
Paing, Aye C, Kathryn A McMillan, Alison F Kirk, Andrew Collier, Allan Hewitt, and Sebastien Chastin. 2019. “Impact of Free-Living Pattern of Sedentary Behaviour on Intra-Day Glucose Regulation in Type 2 Diabetes.” EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 120 (1): 171–79.
Chicago author-date (all authors)
Paing, Aye C, Kathryn A McMillan, Alison F Kirk, Andrew Collier, Allan Hewitt, and Sebastien Chastin. 2019. “Impact of Free-Living Pattern of Sedentary Behaviour on Intra-Day Glucose Regulation in Type 2 Diabetes.” EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 120 (1): 171–179.
Vancouver
1.
Paing AC, McMillan KA, Kirk AF, Collier A, Hewitt A, Chastin S. Impact of free-living pattern of sedentary behaviour on intra-day glucose regulation in type 2 diabetes. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2019;120(1):171–9.
IEEE
[1]
A. C. Paing, K. A. McMillan, A. F. Kirk, A. Collier, A. Hewitt, and S. Chastin, “Impact of free-living pattern of sedentary behaviour on intra-day glucose regulation in type 2 diabetes,” EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, vol. 120, no. 1, pp. 171–179, 2019.
@article{8650743,
  abstract     = {Purpose: To investigate how the pattern of sedentary behaviour affects intra-day glucose regulation in type 2 diabetes.
Methods: This intensive longitudinal study was conducted in 37 participants with type 2 diabetes (age, 62.8 +/- 10.5 years). Glucose and sedentary behaviour/physical activity were assessed with a continuous glucose monitoring (Abbott FreeStyle Libre) and an activity monitor (activPAL3) for 14 days. Multiple regression models with generalised estimating equations (GEEs) approach were used to assess the associations of sedentary time and breaks in sedentary time with pre-breakfast glucose, pre-lunch glucose, pre-dinner glucose, post-breakfast glucose, post-lunch glucose, post-dinner glucose, bedtime glucose, the dawn phenomenon, time in target glucose range (TIR, glucose 3.9-10 mmol/L) and time above target glucose range (TAR, glucose > 10 mmol/L).
Results: Sedentary time was associated with higher pre-breakfast glucose (p = 0.001), pre-dinner glucose (p < 0.001), post-lunch glucose (p = 0.005), post-dinner glucose (p = 0.013) and the dawn phenomenon (p < 0.001). Breaks in sedentary time were associated with lower pre-breakfast glucose (p = 0.023), pre-dinner glucose (p = 0.023), post-breakfast glucose (p < 0.001) and the dawn phenomenon (p = 0.004). The association between sedentary time and less TIR (p = 0.022) and the association between breaks in sedentary time and more TIR (p = 0.001) were also observed.
Conclusions: Reducing sedentary time and promoting breaks in sedentary time could be clinically relevant to improve intra-day glucose regulation in type 2 diabetes.},
  author       = {Paing, Aye C and McMillan, Kathryn A and Kirk, Alison F and Collier, Andrew and Hewitt, Allan and Chastin, Sebastien},
  issn         = {1439-6319},
  journal      = {EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY},
  keywords     = {Type 2 diabetes,Glucose targets,Glycaemic control,Sedentary behaviour,Physical activity,Breaks in sedentary time,GLYCEMIC CONTROL,MICROVASCULAR COMPLICATIONS,PHYSICAL-ACTIVITY,DAWN PHENOMENON,TIME,ASSOCIATION,BREAKS,HYPERGLYCEMIA,DURATION,MODERATE},
  language     = {eng},
  number       = {1},
  pages        = {171--179},
  title        = {Impact of free-living pattern of sedentary behaviour on intra-day glucose regulation in type 2 diabetes},
  url          = {http://dx.doi.org/10.1007/s00421-019-04261-z},
  volume       = {120},
  year         = {2019},
}

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