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Withaferin A : from ayurvedic folk medicine to preclinical anti-cancer drug

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Abstract
Despite the recent successes of targeted cancer immuno-therapies, drug resistance and disease relapse remain a huge burden in cancer patient treatment. This has fueled renewed interest in natural product discovery to identify new pharmacophores for innovative cancer drug development. Reverse pharmacology approaches of Withania somnifera leaves and roots (alternatively also called Ashwagandha or Indian ginseng in traditional Ayurvedic and Unani folk medicine) have identified Withaferin A (WA) as the most bioactive compound for treatment of inflammatory ailments, supporting traditional use of their corresponding extracts in indigenous medicine. In this review we summarize preclinical in vivo evidence for therapeutic cancer applications of WA and provide a biochemical framework of its polypharmaceutical effects against cancer hallmarks.
Keywords
Biochemistry, Pharmacology, Withaferin A, Natural product, Cancer therapy, Drug resistance, Combination therapy, NF-KAPPA-B, BREAST-CANCER CELLS, SHOWS SYNERGISTIC EFFICACY, OF-THE-ART, WITHANIA-SOMNIFERA, NATURAL-PRODUCTS, COMPOUND WITHAFERIN, STEROIDAL LACTONE, DOWN-REGULATION, UP-REGULATION

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Citation

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MLA
Hassannia, Behrouz, et al. “Withaferin A : From Ayurvedic Folk Medicine to Preclinical Anti-Cancer Drug.” BIOCHEMICAL PHARMACOLOGY, vol. 173, 2020.
APA
Hassannia, B., Logie, E., Vandenabeele, P., Vanden Berghe, T., & Vanden Berghe, W. (2020). Withaferin A : from ayurvedic folk medicine to preclinical anti-cancer drug. BIOCHEMICAL PHARMACOLOGY, 173.
Chicago author-date
Hassannia, Behrouz, Emilie Logie, Peter Vandenabeele, Tom Vanden Berghe, and Wim Vanden Berghe. 2020. “Withaferin A : From Ayurvedic Folk Medicine to Preclinical Anti-Cancer Drug.” BIOCHEMICAL PHARMACOLOGY 173.
Chicago author-date (all authors)
Hassannia, Behrouz, Emilie Logie, Peter Vandenabeele, Tom Vanden Berghe, and Wim Vanden Berghe. 2020. “Withaferin A : From Ayurvedic Folk Medicine to Preclinical Anti-Cancer Drug.” BIOCHEMICAL PHARMACOLOGY 173.
Vancouver
1.
Hassannia B, Logie E, Vandenabeele P, Vanden Berghe T, Vanden Berghe W. Withaferin A : from ayurvedic folk medicine to preclinical anti-cancer drug. BIOCHEMICAL PHARMACOLOGY. 2020;173.
IEEE
[1]
B. Hassannia, E. Logie, P. Vandenabeele, T. Vanden Berghe, and W. Vanden Berghe, “Withaferin A : from ayurvedic folk medicine to preclinical anti-cancer drug,” BIOCHEMICAL PHARMACOLOGY, vol. 173, 2020.
@article{8650593,
  abstract     = {Despite the recent successes of targeted cancer immuno-therapies, drug resistance and disease relapse remain a huge burden in cancer patient treatment. This has fueled renewed interest in natural product discovery to identify new pharmacophores for innovative cancer drug development. Reverse pharmacology approaches of Withania somnifera leaves and roots (alternatively also called Ashwagandha or Indian ginseng in traditional Ayurvedic and Unani folk medicine) have identified Withaferin A (WA) as the most bioactive compound for treatment of inflammatory ailments, supporting traditional use of their corresponding extracts in indigenous medicine. In this review we summarize preclinical in vivo evidence for therapeutic cancer applications of WA and provide a biochemical framework of its polypharmaceutical effects against cancer hallmarks.},
  articleno    = {113602},
  author       = {Hassannia, Behrouz and Logie, Emilie and Vandenabeele, Peter and Vanden Berghe, Tom and Vanden Berghe, Wim},
  issn         = {0006-2952},
  journal      = {BIOCHEMICAL PHARMACOLOGY},
  keywords     = {Biochemistry,Pharmacology,Withaferin A,Natural product,Cancer therapy,Drug resistance,Combination therapy,NF-KAPPA-B,BREAST-CANCER CELLS,SHOWS SYNERGISTIC EFFICACY,OF-THE-ART,WITHANIA-SOMNIFERA,NATURAL-PRODUCTS,COMPOUND WITHAFERIN,STEROIDAL LACTONE,DOWN-REGULATION,UP-REGULATION},
  language     = {eng},
  pages        = {11},
  title        = {Withaferin A : from ayurvedic folk medicine to preclinical anti-cancer drug},
  url          = {http://dx.doi.org/10.1016/j.bcp.2019.08.004},
  volume       = {173},
  year         = {2020},
}

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