Advanced search
1 file | 484.45 KB Add to list

Outcomes after distal pancreatectomy with celiac axis resection for pancreatic cancer : a pan-European retrospective cohort study

(2018) ANNALS OF SURGICAL ONCOLOGY. 25(5). p.1440-1447
Author
Organization
Abstract
Western multicenter studies on distal pancreatectomy with celiac axis resection (DP-CAR), also known as the Appleby procedure, for locally advanced pancreatic cancer are lacking. We aimed to study overall survival, morbidity, mortality and the impact of preoperative hepatic artery embolization (PHAE). Retrospective cohort study within the European-African Hepato-Pancreato-Biliary-Association, on DP-CAR between 1-1-2000 and 6-1-2016. Primary endpoint was overall survival. Secondary endpoints were radicality (R0-resection), 90-day mortality, major morbidity, and pancreatic fistulae (grade B/C). We included 68 patients from 20 hospitals in 12 countries. Postoperatively, 53% of patients had R0-resection, 25% major morbidity, 21% an ISGPS grade B/C pancreatic fistula, and 16% mortality. In total, 82% received (neo-)adjuvant chemotherapy and median overall survival in 62 patients with pancreatic ductal adenocarcinoma patients was 18 months (CI 10-37). We observed no impact of PHAE on ischemic complications. DP-CAR combined with chemotherapy for locally advanced pancreatic cancer is associated with acceptable overall survival. The 90-day mortality is too high and should be reduced. Future studies should investigate to what extent increasing surgical volume or better patient selection can improve outcomes.
Keywords
INTERNATIONAL STUDY-GROUP, SURGERY ISGPS, CONSENSUS STATEMENT, FOLFIRINOX, ADENOCARCINOMA, DEFINITION, THERAPY, ARTERY

Downloads

  • Klompmaker2018 Article OutcomesAfterDistalPancreatect.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 484.45 KB

Citation

Please use this url to cite or link to this publication:

MLA
Klompmaker, Sjors, et al. “Outcomes after Distal Pancreatectomy with Celiac Axis Resection for Pancreatic Cancer : A Pan-European Retrospective Cohort Study.” ANNALS OF SURGICAL ONCOLOGY, vol. 25, no. 5, 2018, pp. 1440–47, doi:10.1245/s10434-018-6391-z.
APA
Klompmaker, S., van Hilst, J., Gerritsen, S. L., Adham, M., Quer, M. T. A., Bassi, C., … Besselink, M. G. (2018). Outcomes after distal pancreatectomy with celiac axis resection for pancreatic cancer : a pan-European retrospective cohort study. ANNALS OF SURGICAL ONCOLOGY, 25(5), 1440–1447. https://doi.org/10.1245/s10434-018-6391-z
Chicago author-date
Klompmaker, Sjors, Jony van Hilst, Sarah L Gerritsen, Mustapha Adham, M Teresa Albiol Quer, Claudio Bassi, Frederik Berrevoet, et al. 2018. “Outcomes after Distal Pancreatectomy with Celiac Axis Resection for Pancreatic Cancer : A Pan-European Retrospective Cohort Study.” ANNALS OF SURGICAL ONCOLOGY 25 (5): 1440–47. https://doi.org/10.1245/s10434-018-6391-z.
Chicago author-date (all authors)
Klompmaker, Sjors, Jony van Hilst, Sarah L Gerritsen, Mustapha Adham, M Teresa Albiol Quer, Claudio Bassi, Frederik Berrevoet, Ugo Boggi, Olivier R Busch, Manuela Cesaretti, Raffaele Dalla Valle, Benjamin Darnis, Matteo De Pastena, Marco Del Chiaro, Robert Gruetzmann, Markus K Diener, Traian Dumitrascu, Helmut Friess, Arpad Ivanecz, Anastasios Karayiannakis, Giuseppe K Fusai, Knut J Labori, Carlo Lombardo, Santiago Lopez-Ben, Jean-Yves Mabrut, Willem Niesen, Fernando Pardo, Julie Perinel, Irinel Popescu, Geert Roeyen, Alain Sauvanet, Raj Prasad, Christian Sturesson, Mickael Lesurtel, Jorg Kleeff, Roberto Salvia, and Marc G Besselink. 2018. “Outcomes after Distal Pancreatectomy with Celiac Axis Resection for Pancreatic Cancer : A Pan-European Retrospective Cohort Study.” ANNALS OF SURGICAL ONCOLOGY 25 (5): 1440–1447. doi:10.1245/s10434-018-6391-z.
Vancouver
1.
Klompmaker S, van Hilst J, Gerritsen SL, Adham M, Quer MTA, Bassi C, et al. Outcomes after distal pancreatectomy with celiac axis resection for pancreatic cancer : a pan-European retrospective cohort study. ANNALS OF SURGICAL ONCOLOGY. 2018;25(5):1440–7.
IEEE
[1]
S. Klompmaker et al., “Outcomes after distal pancreatectomy with celiac axis resection for pancreatic cancer : a pan-European retrospective cohort study,” ANNALS OF SURGICAL ONCOLOGY, vol. 25, no. 5, pp. 1440–1447, 2018.
@article{8650202,
  abstract     = {{Western multicenter studies on distal pancreatectomy with celiac axis resection (DP-CAR), also known as the Appleby procedure, for locally advanced pancreatic cancer are lacking. We aimed to study overall survival, morbidity, mortality and the impact of preoperative hepatic artery embolization (PHAE). 
Retrospective cohort study within the European-African Hepato-Pancreato-Biliary-Association, on DP-CAR between 1-1-2000 and 6-1-2016. Primary endpoint was overall survival. Secondary endpoints were radicality (R0-resection), 90-day mortality, major morbidity, and pancreatic fistulae (grade B/C). 
We included 68 patients from 20 hospitals in 12 countries. Postoperatively, 53% of patients had R0-resection, 25% major morbidity, 21% an ISGPS grade B/C pancreatic fistula, and 16% mortality. In total, 82% received (neo-)adjuvant chemotherapy and median overall survival in 62 patients with pancreatic ductal adenocarcinoma patients was 18 months (CI 10-37). We observed no impact of PHAE on ischemic complications. 
DP-CAR combined with chemotherapy for locally advanced pancreatic cancer is associated with acceptable overall survival. The 90-day mortality is too high and should be reduced. Future studies should investigate to what extent increasing surgical volume or better patient selection can improve outcomes.}},
  author       = {{Klompmaker, Sjors and van Hilst, Jony and Gerritsen, Sarah L and Adham, Mustapha and Quer, M Teresa Albiol and Bassi, Claudio and Berrevoet, Frederik and Boggi, Ugo and Busch, Olivier R and Cesaretti, Manuela and Dalla Valle, Raffaele and Darnis, Benjamin and De Pastena, Matteo and Del Chiaro, Marco and Gruetzmann, Robert and Diener, Markus K and Dumitrascu, Traian and Friess, Helmut and Ivanecz, Arpad and Karayiannakis, Anastasios and Fusai, Giuseppe K and Labori, Knut J and Lombardo, Carlo and Lopez-Ben, Santiago and Mabrut, Jean-Yves and Niesen, Willem and Pardo, Fernando and Perinel, Julie and Popescu, Irinel and Roeyen, Geert and Sauvanet, Alain and Prasad, Raj and Sturesson, Christian and Lesurtel, Mickael and Kleeff, Jorg and Salvia, Roberto and Besselink, Marc G}},
  issn         = {{1068-9265}},
  journal      = {{ANNALS OF SURGICAL ONCOLOGY}},
  keywords     = {{INTERNATIONAL STUDY-GROUP,SURGERY ISGPS,CONSENSUS STATEMENT,FOLFIRINOX,ADENOCARCINOMA,DEFINITION,THERAPY,ARTERY}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1440--1447}},
  title        = {{Outcomes after distal pancreatectomy with celiac axis resection for pancreatic cancer : a pan-European retrospective cohort study}},
  url          = {{http://dx.doi.org/10.1245/s10434-018-6391-z}},
  volume       = {{25}},
  year         = {{2018}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: