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Phytohormones : multifunctional nutraceuticals against metabolic syndrome and comorbid diseases

Seowoo Kim (UGent) , Alain Goossens (UGent) , Claude Libert (UGent) , Filip Van Immerseel (UGent) , Jens Staal (UGent) and Rudi Beyaert (UGent)
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Abstract
Metabolic syndrome is characterized by the co-occurrence of diverse symptoms initiating the development of type 2 diabetes, cardiovascular diseases, and a variety of comorbid diseases. The complex constellation of numerous comorbidities makes it difficult to develop common therapeutic approaches that ameliorate these pathological features simultaneously. The plant hormones abscisic acid, salicylic acid, auxin, and cytokinins, have shown promising anti-inflammatory and pro-metabolic effects that could mitigate several disorders relevant to metabolic syndrome. Intriguingly, besides plants, human cells and gut microbes also endogenously produce these molecules, indicating a role in the complex interplay between inflammatory responses associated with metabolic syndrome, the gut microbiome, and nutrition. Here, we introduce how bioactive phytohormones can be generated endogenously and through the gut microbiome. These molecules subsequently influence immune responses and metabolism. We also elaborate on how phytohormones can beneficially modulate metabolic syndrome comorbidities, and propose them as nutraceuticals.
Keywords
Food supplement, Gut microbiome, Metabolic syndrome, Phytohormones, BENZOIC-ACID 2-HYDROXYLASE, TASTE RECEPTOR TAS2R38, HORMONE ABSCISIC-ACID, CYCLIC ADP-RIBOSE, SALICYLIC-ACID, KINETIN-RIBOSIDE, GUT MICROBIOTA, PPAR-GAMMA, INDOLE-3-ACETIC ACID, SIGNAL-TRANSDUCTION

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MLA
Kim, Seowoo, et al. “Phytohormones : Multifunctional Nutraceuticals against Metabolic Syndrome and Comorbid Diseases.” BIOCHEMICAL PHARMACOLOGY, vol. 175, 2020, p. 14.
APA
Kim, S., Goossens, A., Libert, C., Van Immerseel, F., Staal, J., & Beyaert, R. (2020). Phytohormones : multifunctional nutraceuticals against metabolic syndrome and comorbid diseases. BIOCHEMICAL PHARMACOLOGY, 175, 14.
Chicago author-date
Kim, Seowoo, Alain Goossens, Claude Libert, Filip Van Immerseel, Jens Staal, and Rudi Beyaert. 2020. “Phytohormones : Multifunctional Nutraceuticals against Metabolic Syndrome and Comorbid Diseases.” BIOCHEMICAL PHARMACOLOGY 175: 14.
Chicago author-date (all authors)
Kim, Seowoo, Alain Goossens, Claude Libert, Filip Van Immerseel, Jens Staal, and Rudi Beyaert. 2020. “Phytohormones : Multifunctional Nutraceuticals against Metabolic Syndrome and Comorbid Diseases.” BIOCHEMICAL PHARMACOLOGY 175: 14.
Vancouver
1.
Kim S, Goossens A, Libert C, Van Immerseel F, Staal J, Beyaert R. Phytohormones : multifunctional nutraceuticals against metabolic syndrome and comorbid diseases. BIOCHEMICAL PHARMACOLOGY. 2020;175:14.
IEEE
[1]
S. Kim, A. Goossens, C. Libert, F. Van Immerseel, J. Staal, and R. Beyaert, “Phytohormones : multifunctional nutraceuticals against metabolic syndrome and comorbid diseases,” BIOCHEMICAL PHARMACOLOGY, vol. 175, p. 14, 2020.
@article{8649308,
  abstract     = {{Metabolic syndrome is characterized by the co-occurrence of diverse symptoms initiating the development of type 2 diabetes, cardiovascular diseases, and a variety of comorbid diseases. The complex constellation of numerous comorbidities makes it difficult to develop common therapeutic approaches that ameliorate these pathological features simultaneously. The plant hormones abscisic acid, salicylic acid, auxin, and cytokinins, have shown promising anti-inflammatory and pro-metabolic effects that could mitigate several disorders relevant to metabolic syndrome. Intriguingly, besides plants, human cells and gut microbes also endogenously produce these molecules, indicating a role in the complex interplay between inflammatory responses associated with metabolic syndrome, the gut microbiome, and nutrition. Here, we introduce how bioactive phytohormones can be generated endogenously and through the gut microbiome. These molecules subsequently influence immune responses and metabolism. We also elaborate on how phytohormones can beneficially modulate metabolic syndrome comorbidities, and propose them as nutraceuticals.}},
  articleno    = {{113866}},
  author       = {{Kim, Seowoo and Goossens, Alain and Libert, Claude and Van Immerseel, Filip and Staal, Jens and Beyaert, Rudi}},
  issn         = {{0006-2952}},
  journal      = {{BIOCHEMICAL PHARMACOLOGY}},
  keywords     = {{Food supplement,Gut microbiome,Metabolic syndrome,Phytohormones,BENZOIC-ACID 2-HYDROXYLASE,TASTE RECEPTOR TAS2R38,HORMONE ABSCISIC-ACID,CYCLIC ADP-RIBOSE,SALICYLIC-ACID,KINETIN-RIBOSIDE,GUT MICROBIOTA,PPAR-GAMMA,INDOLE-3-ACETIC ACID,SIGNAL-TRANSDUCTION}},
  language     = {{eng}},
  title        = {{Phytohormones : multifunctional nutraceuticals against metabolic syndrome and comorbid diseases}},
  url          = {{http://dx.doi.org/10.1016/j.bcp.2020.113866}},
  volume       = {{175}},
  year         = {{2020}},
}

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