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Mobile technology offers novel insights into the control and treatment of allergic rhinitis : the MASK study

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Abstract
Background: Mobile health can be used to generate innovative insights into optimizing treatment to improve allergic rhinitis (AR) control. Objectives: A cross-sectional real-world observational study was undertaken in 22 countries to complement a pilot study and provide novel information on medication use, disease control, and work productivity in the everyday life of patients with AR. Methods: A mobile phone app (Allergy Diary, which is freely available on Google Play and Apple stores) was used to collect the data of daily visual analogue scale (VAS) scores for (1) overall allergic symptoms; (2) nasal, ocular, and asthma symptoms; (3) work; and (4) medication use by using a treatment scroll list including all allergy medications (prescribed and over-the-counter) customized for 22 countries. The 4 most common intranasal medications containing intranasal corticosteroids and 8 oral H-1-antihistamines were studied. Results: Nine thousand one hundred twenty-two users filled in 112,054 days of VASs in 2016 and 2017. Assessment of days was informative. Control of days with rhinitis differed between no (best control), single (good control for intranasal corticosteroid-treated days), or multiple (worst control) treatments. Users with the worst control increased the range of treatments being used. The same trend was found for asthma, eye symptoms, and work productivity. Differences between oral H-1-antihistamines were found. Conclusions: This study confirms the usefulness of the Allergy Diary in accessing and assessing behavior in patients with AR. This observational study using a very simple assessment tool (VAS) on a mobile phone had the potential to answer questions previously thought infeasible.
Keywords
Allergic rhinitis, antihistamines, asthma, conjunctivitis, corticosteroids, mobile health, MASK, treatment, GUIDED SELF-MANAGEMENT, VISUAL ANALOG SCALE, TRADITIONAL TREATMENT, WORK PRODUCTIVITY, ASTHMA, IMPACT, AZELASTINE, FLUTICASONE, THERAPY, QUALITY

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MLA
Bédard, Annabelle, et al. “Mobile Technology Offers Novel Insights into the Control and Treatment of Allergic Rhinitis : The MASK Study.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 144, no. 1, 2019, pp. 135–43.
APA
Bédard, A., Basagaña, X., Anto, J. M., Garcia-Aymerich, J., Devillier, P., Arnavielhe, S., … Bousquet, J. (2019). Mobile technology offers novel insights into the control and treatment of allergic rhinitis : the MASK study. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 144(1), 135–143.
Chicago author-date
Bédard, Annabelle, Xavier Basagaña, Josep M Anto, Judith Garcia-Aymerich, Philippe Devillier, Sylvie Arnavielhe, Anna Bedbrook, et al. 2019. “Mobile Technology Offers Novel Insights into the Control and Treatment of Allergic Rhinitis : The MASK Study.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 144 (1): 135–43.
Chicago author-date (all authors)
Bédard, Annabelle, Xavier Basagaña, Josep M Anto, Judith Garcia-Aymerich, Philippe Devillier, Sylvie Arnavielhe, Anna Bedbrook, Gabrielle L Onorato, Wienczyslawa Czarlewski, Ruth Murray, Rute Almeida, Joao Fonseca, Elisio Costa, Joao Malva, Mario Morais-Almeida, Ana Margarida Pereira, Ana Todo-Bom, Enrica Menditto, Cristiana Stellato, Maria Teresa Ventura, Alvaro A Cruz, Rafaël Stelmach, Jane da Silva, Désirée Larenas-Linnemann, José M Fuentes-Pérez, Yunuen R Huerta-Villalobos, Regina Emuzyte, Violeta Kvedariene, Arunas Valiulis, Piotr Kuna, Boleslaw Samolinski, Ludger Klimek, Ralph Mösges, Oliver Pfaar, Sara Shamai, Isabelle Annesi-Maesano, Isabelle Bosse, Pascal Demoly, Jean-François Fontaine, Vicky Cardona, Joaquim Mullol, Antonio Valero, Regina E Roller-Wirnsberger, Peter Valentin Tomazic, Niels H Chavannes, Wytske J Fokkens, Sietze Reitsma, Mike Bewick, Dermot Ryan, Aziz Sheikh, Tari Haahtela, Sanna Toppila-Salmi, Erkka Valovirta, Michael Makris, Nikos G Papadopoulos, Emmanuel P Prokopakis, Fotis Psarros, Cemal Cingi, Bilun Gemicioğlu, Arzu Yorgancioglu, Sinthia Bosnic-Anticevich, Robyn E O’Hehir, Claus Bachert, Peter Hellings, Benoit Pugin, Carsten Bindslev-Jensen, Esben Eller, Ingrid Kull, Erik Melén, Magnus Wickman, Gert De Vries, Michiel van Eerd, Ioana Agache, Ignacio J Ansotegui, Mark S Dykewicz, Thomas Casale, Dana Wallace, Susan Waserman, Daniel Laune, and Jean Bousquet. 2019. “Mobile Technology Offers Novel Insights into the Control and Treatment of Allergic Rhinitis : The MASK Study.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 144 (1): 135–143.
Vancouver
1.
Bédard A, Basagaña X, Anto JM, Garcia-Aymerich J, Devillier P, Arnavielhe S, et al. Mobile technology offers novel insights into the control and treatment of allergic rhinitis : the MASK study. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;144(1):135–43.
IEEE
[1]
A. Bédard et al., “Mobile technology offers novel insights into the control and treatment of allergic rhinitis : the MASK study,” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 144, no. 1, pp. 135–143, 2019.
@article{8649079,
  abstract     = {Background: Mobile health can be used to generate innovative insights into optimizing treatment to improve allergic rhinitis (AR) control. 
Objectives: A cross-sectional real-world observational study was undertaken in 22 countries to complement a pilot study and provide novel information on medication use, disease control, and work productivity in the everyday life of patients with AR. 
Methods: A mobile phone app (Allergy Diary, which is freely available on Google Play and Apple stores) was used to collect the data of daily visual analogue scale (VAS) scores for (1) overall allergic symptoms; (2) nasal, ocular, and asthma symptoms; (3) work; and (4) medication use by using a treatment scroll list including all allergy medications (prescribed and over-the-counter) customized for 22 countries. The 4 most common intranasal medications containing intranasal corticosteroids and 8 oral H-1-antihistamines were studied. 
Results: Nine thousand one hundred twenty-two users filled in 112,054 days of VASs in 2016 and 2017. Assessment of days was informative. Control of days with rhinitis differed between no (best control), single (good control for intranasal corticosteroid-treated days), or multiple (worst control) treatments. Users with the worst control increased the range of treatments being used. The same trend was found for asthma, eye symptoms, and work productivity. Differences between oral H-1-antihistamines were found. 
Conclusions: This study confirms the usefulness of the Allergy Diary in accessing and assessing behavior in patients with AR. This observational study using a very simple assessment tool (VAS) on a mobile phone had the potential to answer questions previously thought infeasible.},
  author       = {Bédard, Annabelle and Basagaña, Xavier and Anto, Josep M and Garcia-Aymerich, Judith and Devillier, Philippe and Arnavielhe, Sylvie and Bedbrook, Anna and Onorato, Gabrielle L and Czarlewski, Wienczyslawa and Murray, Ruth and Almeida, Rute and Fonseca, Joao and Costa, Elisio and Malva, Joao and Morais-Almeida, Mario and Pereira, Ana Margarida and Todo-Bom, Ana and Menditto, Enrica and Stellato, Cristiana and Ventura, Maria Teresa and Cruz, Alvaro A and Stelmach, Rafaël and da Silva, Jane and Larenas-Linnemann, Désirée and Fuentes-Pérez, José M and Huerta-Villalobos, Yunuen R and Emuzyte, Regina and Kvedariene, Violeta and Valiulis, Arunas and Kuna, Piotr and Samolinski, Boleslaw and Klimek, Ludger and Mösges, Ralph and Pfaar, Oliver and Shamai, Sara and Annesi-Maesano, Isabelle and Bosse, Isabelle and Demoly, Pascal and Fontaine, Jean-François and Cardona, Vicky and Mullol, Joaquim and Valero, Antonio and Roller-Wirnsberger, Regina E and Tomazic, Peter Valentin and Chavannes, Niels H and Fokkens, Wytske J and Reitsma, Sietze and Bewick, Mike and Ryan, Dermot and Sheikh, Aziz and Haahtela, Tari and Toppila-Salmi, Sanna and Valovirta, Erkka and Makris, Michael and Papadopoulos, Nikos G and Prokopakis, Emmanuel P and Psarros, Fotis and Cingi, Cemal and Gemicioğlu, Bilun and Yorgancioglu, Arzu and Bosnic-Anticevich, Sinthia and O'Hehir, Robyn E and Bachert, Claus and Hellings, Peter and Pugin, Benoit and Bindslev-Jensen, Carsten and Eller, Esben and Kull, Ingrid and Melén, Erik and Wickman, Magnus and De Vries, Gert and van Eerd, Michiel and Agache, Ioana and Ansotegui, Ignacio J and Dykewicz, Mark S and Casale, Thomas and Wallace, Dana and Waserman, Susan and Laune, Daniel and Bousquet, Jean},
  issn         = {0091-6749},
  journal      = {JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY},
  keywords     = {Allergic rhinitis,antihistamines,asthma,conjunctivitis,corticosteroids,mobile health,MASK,treatment,GUIDED SELF-MANAGEMENT,VISUAL ANALOG SCALE,TRADITIONAL TREATMENT,WORK PRODUCTIVITY,ASTHMA,IMPACT,AZELASTINE,FLUTICASONE,THERAPY,QUALITY},
  language     = {eng},
  number       = {1},
  pages        = {135--143},
  title        = {Mobile technology offers novel insights into the control and treatment of allergic rhinitis : the MASK study},
  url          = {http://dx.doi.org/10.1016/j.jaci.2019.01.053},
  volume       = {144},
  year         = {2019},
}

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