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Delayed development of the protective IL-17A response following a Giardia muris infection in neonatal mice

Oonagh Paerewijck (UGent) , Brecht Maertens (UGent) , Aurélie Gagnaire (UGent) , Karolien De Bosscher (UGent) and Peter Geldhof (UGent)
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Abstract
Giardia is an intestinal protozoan parasite that has the ability to infect a wide range of hosts, which can result in the clinical condition 'giardiasis'. Over the years, experimental research has shown the crucial involvement of IL-17A to steer the protective immune response against Giardia. The development of the protective response, as reflected by a significant drop in cyst secretion, typically takes around 3 to 4 weeks. However, early-life infections often have a more chronic character lasting for several weeks or months. Therefore, the aim of the current study was to investigate the dynamics of a Giardia muris infection and the subsequent host immune response in neonatal mice infected 4 days after birth. The outcome of the study showed that a G. muris infection in pre-weaned mice failed to trigger a protective IL-17A response, which could explain the prolonged course of infection in comparison to older mice. Only after weaning, a protective intestinal immune response started to develop, characterized by an upregulation of IL-17A and Mb12 and the secretion of parasite-specific IgA.
Keywords
CRYPTOSPORIDIUM INFECTIONS, LYMPHOCYTE SUBSETS, LAMBLIA INFECTIONS, IMMUNE-RESPONSES, DUODENALIS, CALVES, PREVALENCE, MICROBIOTA, PARASITES, ANTIBODY

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MLA
Paerewijck, Oonagh, et al. “Delayed Development of the Protective IL-17A Response Following a Giardia Muris Infection in Neonatal Mice.” SCIENTIFIC REPORTS, vol. 9, 2019, doi:10.1038/s41598-019-45544-x.
APA
Paerewijck, O., Maertens, B., Gagnaire, A., De Bosscher, K., & Geldhof, P. (2019). Delayed development of the protective IL-17A response following a Giardia muris infection in neonatal mice. SCIENTIFIC REPORTS, 9. https://doi.org/10.1038/s41598-019-45544-x
Chicago author-date
Paerewijck, Oonagh, Brecht Maertens, Aurélie Gagnaire, Karolien De Bosscher, and Peter Geldhof. 2019. “Delayed Development of the Protective IL-17A Response Following a Giardia Muris Infection in Neonatal Mice.” SCIENTIFIC REPORTS 9. https://doi.org/10.1038/s41598-019-45544-x.
Chicago author-date (all authors)
Paerewijck, Oonagh, Brecht Maertens, Aurélie Gagnaire, Karolien De Bosscher, and Peter Geldhof. 2019. “Delayed Development of the Protective IL-17A Response Following a Giardia Muris Infection in Neonatal Mice.” SCIENTIFIC REPORTS 9. doi:10.1038/s41598-019-45544-x.
Vancouver
1.
Paerewijck O, Maertens B, Gagnaire A, De Bosscher K, Geldhof P. Delayed development of the protective IL-17A response following a Giardia muris infection in neonatal mice. SCIENTIFIC REPORTS. 2019;9.
IEEE
[1]
O. Paerewijck, B. Maertens, A. Gagnaire, K. De Bosscher, and P. Geldhof, “Delayed development of the protective IL-17A response following a Giardia muris infection in neonatal mice,” SCIENTIFIC REPORTS, vol. 9, 2019.
@article{8648733,
  abstract     = {{Giardia is an intestinal protozoan parasite that has the ability to infect a wide range of hosts, which can result in the clinical condition 'giardiasis'. Over the years, experimental research has shown the crucial involvement of IL-17A to steer the protective immune response against Giardia. The development of the protective response, as reflected by a significant drop in cyst secretion, typically takes around 3 to 4 weeks. However, early-life infections often have a more chronic character lasting for several weeks or months. Therefore, the aim of the current study was to investigate the dynamics of a Giardia muris infection and the subsequent host immune response in neonatal mice infected 4 days after birth. The outcome of the study showed that a G. muris infection in pre-weaned mice failed to trigger a protective IL-17A response, which could explain the prolonged course of infection in comparison to older mice. Only after weaning, a protective intestinal immune response started to develop, characterized by an upregulation of IL-17A and Mb12 and the secretion of parasite-specific IgA.}},
  articleno    = {{8959}},
  author       = {{Paerewijck, Oonagh and Maertens, Brecht and Gagnaire, Aurélie and De Bosscher, Karolien and Geldhof, Peter}},
  issn         = {{2045-2322}},
  journal      = {{SCIENTIFIC REPORTS}},
  keywords     = {{CRYPTOSPORIDIUM INFECTIONS,LYMPHOCYTE SUBSETS,LAMBLIA INFECTIONS,IMMUNE-RESPONSES,DUODENALIS,CALVES,PREVALENCE,MICROBIOTA,PARASITES,ANTIBODY}},
  language     = {{eng}},
  pages        = {{7}},
  title        = {{Delayed development of the protective IL-17A response following a Giardia muris infection in neonatal mice}},
  url          = {{http://dx.doi.org/10.1038/s41598-019-45544-x}},
  volume       = {{9}},
  year         = {{2019}},
}

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