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Comparative toxicokinetics of Fusarium mycotoxins in pigs and humans

Wim Schelstraete (UGent) , Mathias Devreese (UGent) and Siska Croubels (UGent)
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Abstract
Mycotoxins frequently contaminate food and feed materials, posing a threat to human and animal health. Fusarium species produce important mycotoxins with regard to their occurrence and toxicity, especially deoxynivalenol (DON), fumonisin B1 (FB1), zearalenone (ZEN) and T-2 toxin (T-2). The susceptibility of an animal species towards the effects of these toxins in part depends on the absorption, distribution, metabolism and excretion (ADME processes) of these toxins from the body. For humans, in vivo information is scarce and often animal data is used for extrapolation to humans. From a kinetic and safety point of view, the pig seems to be a promising animal model to aid in the assessment of the toxicological risk of mycotoxins to humans. Qualitatively, the ADME processes seem to be quite similar between pigs and humans. In addition, similar metabolite and excretion patterns are observed, although some quantitative differences are noticed which are subject of this review. The high sensitivity of pigs towards mycotoxins and the similar kinetics are an advantage for the use of this animal species in the risk assessment of mycotoxins, and for the establishment of legal limits of mycotoxins.
Keywords
Toxicokinetics, Mycotoxins, Fusarium, Pig, Human, TOXIN DEOXYNIVALENOL DON, T-2 TOXIN, IN-VITRO, TRICHOTHECENE MYCOTOXIN, CONTAMINATED WHEAT, FUMONISIN B-1, URINARY DEOXYNIVALENOL, ORAL BIOAVAILABILITY, TISSUE DISTRIBUTION, GROWTH-PERFORMANCE

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MLA
Schelstraete, Wim, et al. “Comparative Toxicokinetics of Fusarium Mycotoxins in Pigs and Humans.” FOOD AND CHEMICAL TOXICOLOGY, vol. 137, 2020, doi:10.1016/j.fct.2020.111140.
APA
Schelstraete, W., Devreese, M., & Croubels, S. (2020). Comparative toxicokinetics of Fusarium mycotoxins in pigs and humans. FOOD AND CHEMICAL TOXICOLOGY, 137. https://doi.org/10.1016/j.fct.2020.111140
Chicago author-date
Schelstraete, Wim, Mathias Devreese, and Siska Croubels. 2020. “Comparative Toxicokinetics of Fusarium Mycotoxins in Pigs and Humans.” FOOD AND CHEMICAL TOXICOLOGY 137. https://doi.org/10.1016/j.fct.2020.111140.
Chicago author-date (all authors)
Schelstraete, Wim, Mathias Devreese, and Siska Croubels. 2020. “Comparative Toxicokinetics of Fusarium Mycotoxins in Pigs and Humans.” FOOD AND CHEMICAL TOXICOLOGY 137. doi:10.1016/j.fct.2020.111140.
Vancouver
1.
Schelstraete W, Devreese M, Croubels S. Comparative toxicokinetics of Fusarium mycotoxins in pigs and humans. FOOD AND CHEMICAL TOXICOLOGY. 2020;137.
IEEE
[1]
W. Schelstraete, M. Devreese, and S. Croubels, “Comparative toxicokinetics of Fusarium mycotoxins in pigs and humans,” FOOD AND CHEMICAL TOXICOLOGY, vol. 137, 2020.
@article{8648214,
  abstract     = {Mycotoxins frequently contaminate food and feed materials, posing a threat to human and animal health. Fusarium species produce important mycotoxins with regard to their occurrence and toxicity, especially deoxynivalenol (DON), fumonisin B1 (FB1), zearalenone (ZEN) and T-2 toxin (T-2). The susceptibility of an animal species towards the effects of these toxins in part depends on the absorption, distribution, metabolism and excretion (ADME processes) of these toxins from the body. For humans, in vivo information is scarce and often animal data is used for extrapolation to humans. From a kinetic and safety point of view, the pig seems to be a promising animal model to aid in the assessment of the toxicological risk of mycotoxins to humans. Qualitatively, the ADME processes seem to be quite similar between pigs and humans. In addition, similar metabolite and excretion patterns are observed, although some quantitative differences are noticed which are subject of this review. The high sensitivity of pigs towards mycotoxins and the similar kinetics are an advantage for the use of this animal species in the risk assessment of mycotoxins, and for the establishment of legal limits of mycotoxins.},
  articleno    = {111140},
  author       = {Schelstraete, Wim and Devreese, Mathias and Croubels, Siska},
  issn         = {0278-6915},
  journal      = {FOOD AND CHEMICAL TOXICOLOGY},
  keywords     = {Toxicokinetics,Mycotoxins,Fusarium,Pig,Human,TOXIN DEOXYNIVALENOL DON,T-2 TOXIN,IN-VITRO,TRICHOTHECENE MYCOTOXIN,CONTAMINATED WHEAT,FUMONISIN B-1,URINARY DEOXYNIVALENOL,ORAL BIOAVAILABILITY,TISSUE DISTRIBUTION,GROWTH-PERFORMANCE},
  language     = {eng},
  pages        = {14},
  title        = {Comparative toxicokinetics of Fusarium mycotoxins in pigs and humans},
  url          = {http://dx.doi.org/10.1016/j.fct.2020.111140},
  volume       = {137},
  year         = {2020},
}

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