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Materials and technologies to combat counterfeiting of pharmaceuticals : current and future problem tackling

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Abstract
The globalization of drug trade leads to the expansion of pharmaceutical counterfeiting. The immense threat of low quality drugs to millions of patients is considered to be an under-addressed global health challenge. Analytical authentication technologies are the most effective methods to identify active pharmaceutical ingredients and impurities. However, most of these analytical testing techniques are expensive and need skilled personnel. To combat counterfeiting of drugs, the package of an increasing number of drugs is being protected through advanced package labeling technologies. Though, package labeling is only effective if the drugs are not repackaged. Therefore "in-drug labeling," instead of "drug package labeling," may become powerful tools to protect drugs. This review aims to overview how advanced micro- and nanomaterials might become interesting markers for the labeling of tablets and capsules. Clearly, how well such identifiers can be integrated into "solid drugs" without compromising drug safety and efficacy remains a challenge. Also, incorporation of tags has so far only been reported for the protection of solid drug dosage forms. No doubts that in-drug labeling technologies for "liquid drugs," like injectables which contain expensive peptides, monoclonal antibodies, vaccines, dermal fillers, could help to protect them from counterfeiting as well.
Keywords
anticounterfeiting, counterfeit pharmaceuticals, in-drug labeling, tags, TRANSFORM INFRARED-SPECTROSCOPY, X-RAY-DIFFRACTION, INTRAVITREAL INJECTION, ENCODING MICROCARRIERS, ANTIMALARIAL TABLETS, FALSIFIED MEDICINES, RAMAN-SPECTROSCOPY, TITANIUM-DIOXIDE, DRUGS, IDENTIFICATION

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MLA
Zhang, Heyang, et al. “Materials and Technologies to Combat Counterfeiting of Pharmaceuticals : Current and Future Problem Tackling.” ADVANCED MATERIALS, vol. 32, no. 11, 2020, doi:10.1002/adma.201905486.
APA
Zhang, H., Hua, D., Huang, C., Samal, S. K., Xiong, R., Sauvage, F., … De Smedt, S. (2020). Materials and technologies to combat counterfeiting of pharmaceuticals : current and future problem tackling. ADVANCED MATERIALS, 32(11). https://doi.org/10.1002/adma.201905486
Chicago author-date
Zhang, Heyang, Dawei Hua, Chaobo Huang, Sangram Keshari Samal, Ranhua Xiong, Félix Sauvage, Kevin Braeckmans, Katrien Remaut, and Stefaan De Smedt. 2020. “Materials and Technologies to Combat Counterfeiting of Pharmaceuticals : Current and Future Problem Tackling.” ADVANCED MATERIALS 32 (11). https://doi.org/10.1002/adma.201905486.
Chicago author-date (all authors)
Zhang, Heyang, Dawei Hua, Chaobo Huang, Sangram Keshari Samal, Ranhua Xiong, Félix Sauvage, Kevin Braeckmans, Katrien Remaut, and Stefaan De Smedt. 2020. “Materials and Technologies to Combat Counterfeiting of Pharmaceuticals : Current and Future Problem Tackling.” ADVANCED MATERIALS 32 (11). doi:10.1002/adma.201905486.
Vancouver
1.
Zhang H, Hua D, Huang C, Samal SK, Xiong R, Sauvage F, et al. Materials and technologies to combat counterfeiting of pharmaceuticals : current and future problem tackling. ADVANCED MATERIALS. 2020;32(11).
IEEE
[1]
H. Zhang et al., “Materials and technologies to combat counterfeiting of pharmaceuticals : current and future problem tackling,” ADVANCED MATERIALS, vol. 32, no. 11, 2020.
@article{8646429,
  abstract     = {The globalization of drug trade leads to the expansion of pharmaceutical counterfeiting. The immense threat of low quality drugs to millions of patients is considered to be an under-addressed global health challenge. Analytical authentication technologies are the most effective methods to identify active pharmaceutical ingredients and impurities. However, most of these analytical testing techniques are expensive and need skilled personnel. To combat counterfeiting of drugs, the package of an increasing number of drugs is being protected through advanced package labeling technologies. Though, package labeling is only effective if the drugs are not repackaged. Therefore "in-drug labeling," instead of "drug package labeling," may become powerful tools to protect drugs. This review aims to overview how advanced micro- and nanomaterials might become interesting markers for the labeling of tablets and capsules. Clearly, how well such identifiers can be integrated into "solid drugs" without compromising drug safety and efficacy remains a challenge. Also, incorporation of tags has so far only been reported for the protection of solid drug dosage forms. No doubts that in-drug labeling technologies for "liquid drugs," like injectables which contain expensive peptides, monoclonal antibodies, vaccines, dermal fillers, could help to protect them from counterfeiting as well.},
  articleno    = {1905486},
  author       = {Zhang, Heyang and Hua, Dawei and Huang, Chaobo and Samal, Sangram Keshari and Xiong, Ranhua and Sauvage, Félix and Braeckmans, Kevin and Remaut, Katrien and De Smedt, Stefaan},
  issn         = {0935-9648},
  journal      = {ADVANCED MATERIALS},
  keywords     = {anticounterfeiting,counterfeit pharmaceuticals,in-drug labeling,tags,TRANSFORM INFRARED-SPECTROSCOPY,X-RAY-DIFFRACTION,INTRAVITREAL INJECTION,ENCODING MICROCARRIERS,ANTIMALARIAL TABLETS,FALSIFIED MEDICINES,RAMAN-SPECTROSCOPY,TITANIUM-DIOXIDE,DRUGS,IDENTIFICATION},
  language     = {eng},
  number       = {11},
  pages        = {13},
  title        = {Materials and technologies to combat counterfeiting of pharmaceuticals : current and future problem tackling},
  url          = {http://dx.doi.org/10.1002/adma.201905486},
  volume       = {32},
  year         = {2020},
}

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