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Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide: Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol

(2019) CHEMISTRYSELECT. 4(38). p.11398-11405
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Abstract
New Pd(II) and Pt(II) complexes are described in which the multidentate phosphorus ylides [Ph2P(CH2)(n)PPh2=C(H)C(O)C6H4-p-OCH3] (n=1, (Y1); n=2, (Y2)) act as P,C chelating ligands. The chelating ability of these ligands resulted in the formation of [MBr2{K-2(P,C)-Y1}] (M=Pd (1), Pt (2)); [MBr2{K-2(P,C)-Y2}] (M=Pd (3), Pt (4) complexes, which were investigated using physicochemical techniques. X-ray diffraction studies of a single crystal of complex 2 confirmed the structure of the five-membered ring. Owing to the redox activity of phosphorus-ylide complexes, their electrocatalytic activity for the oxidation of methanol has been studied. All compounds were found to possess the anti-proliferative potency against MCF-7 (breast carcinoma), A549 (non-small lung carcinoma) and AGS (gastric carcinoma) cell lines with average IC50 values in the range of 14.53 to 287.92 mu M. In general, the compounds Y1, Y2, 2, and 3 displayed high anticancer activities compared to 1 and 4. The antioxidant activity of the compounds, which was estimated by 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging, was moderate to strong with IC50 values in the range 0.18 to 0.59 mg mL(-1).

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MLA
Hashemi, Mojdeh Sadat, et al. “Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide: Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol.” CHEMISTRYSELECT, vol. 4, no. 38, 2019, pp. 11398–405.
APA
Hashemi, M. S., Sabounchei, S. J., Karamian, R., Farida, S. H. M., Rahmani, N., Roushani, M., & Van Hecke, K. (2019). Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide: Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol. CHEMISTRYSELECT, 4(38), 11398–11405.
Chicago author-date
Hashemi, Mojdeh Sadat, Seyyed Javad Sabounchei, Roya Karamian, Seyed Hamed Moazzami Farida, Nosrat Rahmani, Mahmoud Roushani, and Kristof Van Hecke. 2019. “Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide: Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol.” CHEMISTRYSELECT 4 (38): 11398–405.
Chicago author-date (all authors)
Hashemi, Mojdeh Sadat, Seyyed Javad Sabounchei, Roya Karamian, Seyed Hamed Moazzami Farida, Nosrat Rahmani, Mahmoud Roushani, and Kristof Van Hecke. 2019. “Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide: Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol.” CHEMISTRYSELECT 4 (38): 11398–11405.
Vancouver
1.
Hashemi MS, Sabounchei SJ, Karamian R, Farida SHM, Rahmani N, Roushani M, et al. Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide: Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol. CHEMISTRYSELECT. 2019;4(38):11398–405.
IEEE
[1]
M. S. Hashemi et al., “Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide: Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol,” CHEMISTRYSELECT, vol. 4, no. 38, pp. 11398–11405, 2019.
@article{8645672,
  abstract     = {New Pd(II) and Pt(II) complexes are described in which the multidentate phosphorus ylides [Ph2P(CH2)(n)PPh2=C(H)C(O)C6H4-p-OCH3] (n=1, (Y1); n=2, (Y2)) act as P,C chelating ligands. The chelating ability of these ligands resulted in the formation of [MBr2{K-2(P,C)-Y1}] (M=Pd (1), Pt (2)); [MBr2{K-2(P,C)-Y2}] (M=Pd (3), Pt (4) complexes, which were investigated using physicochemical techniques. X-ray diffraction studies of a single crystal of complex 2 confirmed the structure of the five-membered ring. Owing to the redox activity of phosphorus-ylide complexes, their electrocatalytic activity for the oxidation of methanol has been studied. All compounds were found to possess the anti-proliferative potency against MCF-7 (breast carcinoma), A549 (non-small lung carcinoma) and AGS (gastric carcinoma) cell lines with average IC50 values in the range of 14.53 to 287.92 mu M. In general, the compounds Y1, Y2, 2, and 3 displayed high anticancer activities compared to 1 and 4. The antioxidant activity of the compounds, which was estimated by 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging, was moderate to strong with IC50 values in the range 0.18 to 0.59 mg mL(-1).},
  author       = {Hashemi, Mojdeh Sadat and Sabounchei, Seyyed Javad and Karamian, Roya and Farida, Seyed Hamed Moazzami and Rahmani, Nosrat and Roushani, Mahmoud and Van Hecke, Kristof},
  issn         = {2365-6549},
  journal      = {CHEMISTRYSELECT},
  number       = {38},
  pages        = {11398--11405},
  title        = {Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide: Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol},
  url          = {http://dx.doi.org/10.1002/slct.201902065},
  volume       = {4},
  year         = {2019},
}

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