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Atherosclerotic calcification in major vessel beds in chronic obstructive pulmonary disease : the Rotterdam Study

(2019) ATHEROSCLEROSIS. 291. p.107-113
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Abstract
Background and aims: COPD is associated with an increased risk of cardiovascular morbidity and mortality, potentially by mechanisms of atherosclerosis. Insight into location-specific vulnerability to atherosclerosis in COPD, including intracranial arteries, is lacking. We aimed to investigate the relation between COPD and atherosclerosis in multiple vessel beds within a large population-based cohort study. Methods: From 2003 to 2006, a random sample of 2187 elderly participants (mean age, 69.6 +/- 6.8 years; 50.9% female; 11.7% COPD) from the population-based Rotterdam Study underwent computed tomography to quantify atherosclerotic coronary artery calcification (CAC), aortic arch calcification (AAC), extracranial carotid artery calcification (ECAC), and intracranial carotid artery calcification (ICAC). We investigated the association of COPD [ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC) < 70%] with the presence of calcification and with calcification volumes in each vessel bed using logistic and linear regression, with adjustments for cardiovascular risk factors including smoking. Results: The prevalence of CAC, AAC and ECAC was significantly higher in subjects with COPD compared to those without. After adjusting for age and smoking, COPD remained associated with the presence of ECAC (odds ratio 1.46 [95% confidence interval, 1.02-2.07, p = 0.037]). COPD was significantly associated with larger calcification volumes in all four vessel beds in people in whom calcification was present. Conclusions: The results of this study suggest that COPD plays a role in extracranial carotid artery atherosclerosis initiation and systemic atherosclerosis aggravation.
Keywords
Airflow obstruction, Chronic, Lung, Arteriosclerosis, Computed tomography, Epidemiology, CORONARY-ARTERY CALCIUM, AIR-FLOW LIMITATION, CAROTID ATHEROSCLEROSIS, RISK-FACTORS, ASSOCIATION, COPD, COMORBIDITIES, PREVENTION, MANAGEMENT, DIAGNOSIS

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Citation

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MLA
Lahousse, Lies, et al. “Atherosclerotic Calcification in Major Vessel Beds in Chronic Obstructive Pulmonary Disease : The Rotterdam Study.” ATHEROSCLEROSIS, vol. 291, 2019, pp. 107–13.
APA
Lahousse, L., Bos, D., Wijnant, S., Kavousi, M., Stricker, B. H., van der Lugt, A., … Brusselle, G. (2019). Atherosclerotic calcification in major vessel beds in chronic obstructive pulmonary disease : the Rotterdam Study. ATHEROSCLEROSIS, 291, 107–113.
Chicago author-date
Lahousse, Lies, Daniel Bos, Sara Wijnant, Maryam Kavousi, Bruno H. Stricker, Aad van der Lugt, Meike W. Vernooij, and Guy Brusselle. 2019. “Atherosclerotic Calcification in Major Vessel Beds in Chronic Obstructive Pulmonary Disease : The Rotterdam Study.” ATHEROSCLEROSIS 291: 107–13.
Chicago author-date (all authors)
Lahousse, Lies, Daniel Bos, Sara Wijnant, Maryam Kavousi, Bruno H. Stricker, Aad van der Lugt, Meike W. Vernooij, and Guy Brusselle. 2019. “Atherosclerotic Calcification in Major Vessel Beds in Chronic Obstructive Pulmonary Disease : The Rotterdam Study.” ATHEROSCLEROSIS 291: 107–113.
Vancouver
1.
Lahousse L, Bos D, Wijnant S, Kavousi M, Stricker BH, van der Lugt A, et al. Atherosclerotic calcification in major vessel beds in chronic obstructive pulmonary disease : the Rotterdam Study. ATHEROSCLEROSIS. 2019;291:107–13.
IEEE
[1]
L. Lahousse et al., “Atherosclerotic calcification in major vessel beds in chronic obstructive pulmonary disease : the Rotterdam Study,” ATHEROSCLEROSIS, vol. 291, pp. 107–113, 2019.
@article{8645220,
  abstract     = {Background and aims: COPD is associated with an increased risk of cardiovascular morbidity and mortality, potentially by mechanisms of atherosclerosis. Insight into location-specific vulnerability to atherosclerosis in COPD, including intracranial arteries, is lacking. We aimed to investigate the relation between COPD and atherosclerosis in multiple vessel beds within a large population-based cohort study.

Methods: From 2003 to 2006, a random sample of 2187 elderly participants (mean age, 69.6 +/- 6.8 years; 50.9% female; 11.7% COPD) from the population-based Rotterdam Study underwent computed tomography to quantify atherosclerotic coronary artery calcification (CAC), aortic arch calcification (AAC), extracranial carotid artery calcification (ECAC), and intracranial carotid artery calcification (ICAC). We investigated the association of COPD [ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC) < 70%] with the presence of calcification and with calcification volumes in each vessel bed using logistic and linear regression, with adjustments for cardiovascular risk factors including smoking.

Results: The prevalence of CAC, AAC and ECAC was significantly higher in subjects with COPD compared to those without. After adjusting for age and smoking, COPD remained associated with the presence of ECAC (odds ratio 1.46 [95% confidence interval, 1.02-2.07, p = 0.037]). COPD was significantly associated with larger calcification volumes in all four vessel beds in people in whom calcification was present.

Conclusions: The results of this study suggest that COPD plays a role in extracranial carotid artery atherosclerosis initiation and systemic atherosclerosis aggravation.},
  author       = {Lahousse, Lies and Bos, Daniel and Wijnant, Sara and Kavousi, Maryam and Stricker, Bruno H. and van der Lugt, Aad and Vernooij, Meike W. and Brusselle, Guy},
  issn         = {0021-9150},
  journal      = {ATHEROSCLEROSIS},
  keywords     = {Airflow obstruction,Chronic,Lung,Arteriosclerosis,Computed tomography,Epidemiology,CORONARY-ARTERY CALCIUM,AIR-FLOW LIMITATION,CAROTID ATHEROSCLEROSIS,RISK-FACTORS,ASSOCIATION,COPD,COMORBIDITIES,PREVENTION,MANAGEMENT,DIAGNOSIS},
  language     = {eng},
  pages        = {107--113},
  title        = {Atherosclerotic calcification in major vessel beds in chronic obstructive pulmonary disease : the Rotterdam Study},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2019.10.014},
  volume       = {291},
  year         = {2019},
}

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