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Disproportion and dysmorphism in an adult Belgian population with Turner syndrome : risk factors for chronic diseases?

(2020) ACTA CLINICA BELGICA. 75(4). p.258-266
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Abstract
Background Turner syndrome (TS) is characterized by dysmorphism and body disproportion. TS women are also susceptible to a range of chronic disorders including arterial hypertension (AHT), osteoporosis, sensorineural hearing loss (SNHL), type 2 diabetes mellitus (DM2) and thyroid disease. The association between dysmorphism/body disproportion and chronic disease has never been studied in TS women. The effect of growth hormone treatment on body disproportion is also unclear. Objectives: to analyze dysmorphic features and body disproportion in TS women in relation to the presence of chronic disease and to document the effect of growth hormone therapy on body disproportion. Method 76 adult TS women with a regular follow up at the TS clinic UZ Ghent were invited to participate. Detailed body measurements were performed in 44 volunteering TS women. Scoring systems for overall dysmorphism, craniofacial dysmorphism, thoracic and limb abnormalities and skeletal disproportion were developed. Results TS women with a higher dysmorphism score were more at risk for AHT (p = 0.04) as well as those with a higher sitting height/standing height ratio (p < 0.05). Prevalence of AHT, osteoporosis and DM 2 was lower in TS women treated with GH during childhood (p < 0.05). Conclusions Adult TS women with relatively short legs or with more physical dysmorphic stigmata were more at risk for AHT. GH therapy does not seem to increase the risk of chronic disease on the long term.
Keywords
General Medicine

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MLA
Van de Kelft, An-Sofie, et al. “Disproportion and Dysmorphism in an Adult Belgian Population with Turner Syndrome : Risk Factors for Chronic Diseases?” ACTA CLINICA BELGICA, vol. 75, no. 4, 2020, pp. 258–66, doi:10.1080/17843286.2019.1606761.
APA
Van de Kelft, A.-S., Lievens, C., De Groote, K., Demulier, L., De Backer, J., T’Sjoen, G., … De Schepper, J. (2020). Disproportion and dysmorphism in an adult Belgian population with Turner syndrome : risk factors for chronic diseases? ACTA CLINICA BELGICA, 75(4), 258–266. https://doi.org/10.1080/17843286.2019.1606761
Chicago author-date
Van de Kelft, An-Sofie, Charlotte Lievens, Katya De Groote, Laurent Demulier, Julie De Backer, Guy T’Sjoen, Margarita Craen, Bert Callewaert, and Jean De Schepper. 2020. “Disproportion and Dysmorphism in an Adult Belgian Population with Turner Syndrome : Risk Factors for Chronic Diseases?” ACTA CLINICA BELGICA 75 (4): 258–66. https://doi.org/10.1080/17843286.2019.1606761.
Chicago author-date (all authors)
Van de Kelft, An-Sofie, Charlotte Lievens, Katya De Groote, Laurent Demulier, Julie De Backer, Guy T’Sjoen, Margarita Craen, Bert Callewaert, and Jean De Schepper. 2020. “Disproportion and Dysmorphism in an Adult Belgian Population with Turner Syndrome : Risk Factors for Chronic Diseases?” ACTA CLINICA BELGICA 75 (4): 258–266. doi:10.1080/17843286.2019.1606761.
Vancouver
1.
Van de Kelft A-S, Lievens C, De Groote K, Demulier L, De Backer J, T’Sjoen G, et al. Disproportion and dysmorphism in an adult Belgian population with Turner syndrome : risk factors for chronic diseases? ACTA CLINICA BELGICA. 2020;75(4):258–66.
IEEE
[1]
A.-S. Van de Kelft et al., “Disproportion and dysmorphism in an adult Belgian population with Turner syndrome : risk factors for chronic diseases?,” ACTA CLINICA BELGICA, vol. 75, no. 4, pp. 258–266, 2020.
@article{8645214,
  abstract     = {Background Turner syndrome (TS) is characterized by dysmorphism and body disproportion. TS women are also susceptible to a range of chronic disorders including arterial hypertension (AHT), osteoporosis, sensorineural hearing loss (SNHL), type 2 diabetes mellitus (DM2) and thyroid disease. The association between dysmorphism/body disproportion and chronic disease has never been studied in TS women. The effect of growth hormone treatment on body disproportion is also unclear. Objectives: to analyze dysmorphic features and body disproportion in TS women in relation to the presence of chronic disease and to document the effect of growth hormone therapy on body disproportion. Method 76 adult TS women with a regular follow up at the TS clinic UZ Ghent were invited to participate. Detailed body measurements were performed in 44 volunteering TS women. Scoring systems for overall dysmorphism, craniofacial dysmorphism, thoracic and limb abnormalities and skeletal disproportion were developed. Results TS women with a higher dysmorphism score were more at risk for AHT (p = 0.04) as well as those with a higher sitting height/standing height ratio (p < 0.05). Prevalence of AHT, osteoporosis and DM 2 was lower in TS women treated with GH during childhood (p < 0.05). Conclusions Adult TS women with relatively short legs or with more physical dysmorphic stigmata were more at risk for AHT. GH therapy does not seem to increase the risk of chronic disease on the long term.},
  author       = {Van de Kelft, An-Sofie and Lievens, Charlotte and De Groote, Katya and Demulier, Laurent and De Backer, Julie and T'Sjoen, Guy and Craen, Margarita and Callewaert, Bert and De Schepper, Jean},
  issn         = {1784-3286},
  journal      = {ACTA CLINICA BELGICA},
  keywords     = {General Medicine},
  language     = {eng},
  number       = {4},
  pages        = {258--266},
  title        = {Disproportion and dysmorphism in an adult Belgian population with Turner syndrome : risk factors for chronic diseases?},
  url          = {http://dx.doi.org/10.1080/17843286.2019.1606761},
  volume       = {75},
  year         = {2020},
}

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