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Diversified sources for human infections by Salmonella enterica serovar newport

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Abstract
Salmonella enterica Newport (S. Newport), with phylogenetic diversity feature, contributes to significant public health concerns. Our previous study suggested that S. Newport from multiple animal-borne routes, with distinct antibiotic resistant pattern, might transmit to human. However, their genetic information was lacking. As a complement to the earlier finding, we investigate the relationship between each other among the hosts, sources, genotype and antibiotic resistance in S. Newport. We used the multilocus sequence typing (MLST) in conjunction with minimum inhibitory concentration of 16 antibiotics of globally sampled 1842 S. Newport strains, including 282 newly contributed Chinese strains, to evaluate this association. Our analysis reveals that sequence types (STs) are significantly associated with different host sources, including livestock (ST45), birds (ST5), contaminated water and soil (ST118), reptiles (ST46) and seafood (ST31). Importantly, ST45 contained most of (344/553) the multi-drug resistance (MDR) strains, which were believed to be responsible for human MDR bacterial infections. Chinese isolates were detected to form two unique lineages of avian (ST808 group) and freshwater animal (ST2364 group) origin. Taken together, genotyping information of S. Newport could serve to improve Salmonella source-originated diagnostics and guide better selection of antibiotic therapy against Salmonella infections.
Keywords
antibiotic resistance, bovine, plant, Salmonella Newport, sequence type, sources

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MLA
Pan, Hang, et al. “Diversified Sources for Human Infections by Salmonella Enterica Serovar Newport.” TRANSBOUNDARY AND EMERGING DISEASES, vol. 66, no. 2, 2019, pp. 1044–48.
APA
Pan, H., Zhou, X., Chai, W., Paudyal, N., Li, S., Zhou, X., … Yue, M. (2019). Diversified sources for human infections by Salmonella enterica serovar newport. TRANSBOUNDARY AND EMERGING DISEASES, 66(2), 1044–1048.
Chicago author-date
Pan, Hang, Xin Zhou, Wenqin Chai, Narayan Paudyal, Shuning Li, Xiao Zhou, Kun Zhou, et al. 2019. “Diversified Sources for Human Infections by Salmonella Enterica Serovar Newport.” TRANSBOUNDARY AND EMERGING DISEASES 66 (2): 1044–48.
Chicago author-date (all authors)
Pan, Hang, Xin Zhou, Wenqin Chai, Narayan Paudyal, Shuning Li, Xiao Zhou, Kun Zhou, Qingqing Wu, Beibei Wu, Guogang Li, Andreja Rajkovic, Weihuan Fang, Shelley C Rankin, Yan Li, Xuebin Xu, Dieter M Schifferli, and Min Yue. 2019. “Diversified Sources for Human Infections by Salmonella Enterica Serovar Newport.” TRANSBOUNDARY AND EMERGING DISEASES 66 (2): 1044–1048.
Vancouver
1.
Pan H, Zhou X, Chai W, Paudyal N, Li S, Zhou X, et al. Diversified sources for human infections by Salmonella enterica serovar newport. TRANSBOUNDARY AND EMERGING DISEASES. 2019;66(2):1044–8.
IEEE
[1]
H. Pan et al., “Diversified sources for human infections by Salmonella enterica serovar newport,” TRANSBOUNDARY AND EMERGING DISEASES, vol. 66, no. 2, pp. 1044–1048, 2019.
@article{8645013,
  abstract     = {Salmonella enterica Newport (S. Newport), with phylogenetic diversity feature, contributes to significant public health concerns. Our previous study suggested that S. Newport from multiple animal-borne routes, with distinct antibiotic resistant pattern, might transmit to human. However, their genetic information was lacking. As a complement to the earlier finding, we investigate the relationship between each other among the hosts, sources, genotype and antibiotic resistance in S. Newport. We used the multilocus sequence typing (MLST) in conjunction with minimum inhibitory concentration of 16 antibiotics of globally sampled 1842 S. Newport strains, including 282 newly contributed Chinese strains, to evaluate this association. Our analysis reveals that sequence types (STs) are significantly associated with different host sources, including livestock (ST45), birds (ST5), contaminated water and soil (ST118), reptiles (ST46) and seafood (ST31). Importantly, ST45 contained most of (344/553) the multi-drug resistance (MDR) strains, which were believed to be responsible for human MDR bacterial infections. Chinese isolates were detected to form two unique lineages of avian (ST808 group) and freshwater animal (ST2364 group) origin. Taken together, genotyping information of S. Newport could serve to improve Salmonella source-originated diagnostics and guide better selection of antibiotic therapy against Salmonella infections.},
  author       = {Pan, Hang and Zhou, Xin and Chai, Wenqin and Paudyal, Narayan and Li, Shuning and Zhou, Xiao and Zhou, Kun and Wu, Qingqing and Wu, Beibei and Li, Guogang and Rajkovic, Andreja and Fang, Weihuan and Rankin, Shelley C and Li, Yan and Xu, Xuebin and Schifferli, Dieter M and Yue, Min},
  issn         = {1865-1674},
  journal      = {TRANSBOUNDARY AND EMERGING DISEASES},
  keywords     = {antibiotic resistance,bovine,plant,Salmonella Newport,sequence type,sources},
  language     = {eng},
  number       = {2},
  pages        = {1044--1048},
  title        = {Diversified sources for human infections by Salmonella enterica serovar newport},
  url          = {http://dx.doi.org/10.1111/tbed.13099},
  volume       = {66},
  year         = {2019},
}

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