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Salicylic acid targets protein phosphatase 2A to attenuate growth in plants

(2020) CURRENT BIOLOGY. 30. p.381-395
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Abstract
Plants, like other multicellular organisms, survive through a delicate balance between growth and defense against pathogens. Salicylic acid (SA) is a major defense signal in plants, and the perception mechanism as well as downstream signaling activating the immune response are known. Here, we identify a parallel SA signaling that mediates growth attenuation. SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. Among PP2A targets, the PIN2 auxin transporter is hyperphosphorylated in response to SA, leading to changed activity of this important growth regulator. Accordingly, auxin transport and auxin-mediated root development, including growth, gravitropic response, and lateral root organogenesis, are inhibited. This study reveals how SA, besides activating immunity, concomitantly attenuates growth through crosstalk with the auxin distribution network. Further analysis of this dual role of SA and characterization of additional SA-regulated PP2A targets will provide further insights into mechanisms maintaining a balance between growth and defense.
Keywords
POLAR AUXIN TRANSPORT, DEFENSE RESPONSES, CELL-DIVISION, ARABIDOPSIS, NPR1, RESISTANCE, BIOSYNTHESIS, ACCUMULATION, TRAFFICKING, MEMBRANE

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MLA
Tan, Shutang, et al. “Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants.” CURRENT BIOLOGY, vol. 30, 2020, pp. 381–95.
APA
Tan, S., Abas, M., Verstraeten, I., Glanc, M., Molnár, G., Hajný, J., … Friml, J. (2020). Salicylic acid targets protein phosphatase 2A to attenuate growth in plants. CURRENT BIOLOGY, 30, 381–395.
Chicago author-date
Tan, Shutang, Melinda Abas, Inge Verstraeten, Matouš Glanc, Gergely Molnár, Jakub Hajný, Pavel Lasák, et al. 2020. “Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants.” CURRENT BIOLOGY 30: 381–95.
Chicago author-date (all authors)
Tan, Shutang, Melinda Abas, Inge Verstraeten, Matouš Glanc, Gergely Molnár, Jakub Hajný, Pavel Lasák, Ivan Petřík, Eugenia Russinova, Jan Petrášek, Ondřej Novák, Jiří Pospíšil, and Jiří Friml. 2020. “Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants.” CURRENT BIOLOGY 30: 381–395.
Vancouver
1.
Tan S, Abas M, Verstraeten I, Glanc M, Molnár G, Hajný J, et al. Salicylic acid targets protein phosphatase 2A to attenuate growth in plants. CURRENT BIOLOGY. 2020;30:381–95.
IEEE
[1]
S. Tan et al., “Salicylic acid targets protein phosphatase 2A to attenuate growth in plants,” CURRENT BIOLOGY, vol. 30, pp. 381–395, 2020.
@article{8644016,
  abstract     = {{Plants, like other multicellular organisms, survive through a delicate balance between growth and defense against pathogens. Salicylic acid (SA) is a major defense signal in plants, and the perception mechanism as well as downstream signaling activating the immune response are known. Here, we identify a parallel SA signaling that mediates growth attenuation. SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. Among PP2A targets, the PIN2 auxin transporter is hyperphosphorylated in response to SA, leading to changed activity of this important growth regulator. Accordingly, auxin transport and auxin-mediated root development, including growth, gravitropic response, and lateral root organogenesis, are inhibited. This study reveals how SA, besides activating immunity, concomitantly attenuates growth through crosstalk with the auxin distribution network. Further analysis of this dual role of SA and characterization of additional SA-regulated PP2A targets will provide further insights into mechanisms maintaining a balance between growth and defense.}},
  author       = {{Tan, Shutang and Abas, Melinda and Verstraeten, Inge and Glanc, Matouš and Molnár, Gergely and Hajný, Jakub and Lasák, Pavel and Petřík, Ivan and Russinova, Eugenia and Petrášek, Jan and Novák, Ondřej and Pospíšil, Jiří and Friml, Jiří}},
  issn         = {{0960-9822}},
  journal      = {{CURRENT BIOLOGY}},
  keywords     = {{POLAR AUXIN TRANSPORT,DEFENSE RESPONSES,CELL-DIVISION,ARABIDOPSIS,NPR1,RESISTANCE,BIOSYNTHESIS,ACCUMULATION,TRAFFICKING,MEMBRANE}},
  language     = {{eng}},
  pages        = {{381--395}},
  title        = {{Salicylic acid targets protein phosphatase 2A to attenuate growth in plants}},
  url          = {{http://dx.doi.org/10.1016/j.cub.2019.11.058}},
  volume       = {{30}},
  year         = {{2020}},
}

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