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Noninvasive cardiac output and central systolic pressure from cuff-pressure and pulse wave velocity

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Abstract
Goal: We introduce a novel approach to estimate cardiac output (CO) and central systolic blood pressure (cSBP) from noninvasive measurements of peripheral cuff-pressure and carotid-to-femoral pulse wave velocity (cf-PWV). Methods: The adjustment of a previously validated one-dimensional arterial tree model is achieved via an optimization process. In the optimization loop, compliance and resistance of the generic arterial tree model as well as aortic flow are adjusted so that simulated brachial systolic and diastolic pressures and cf-PWV converge towards the measured brachial systolic and diastolic pressures and cf-PWV. The process is repeated until full convergence in terms of both brachial pressures and cf-PWV is reached. To assess the accuracy of the proposed framework, we implemented the algorithm on in vivo anonymized data from 20 subjects and compared the method-derived estimates of CO and cSBP to patient-specific measurements obtained with Mobil-O-Graph apparatus (central pressure) and two-dimensional transthoracic echocardiography (aortic blood flow). Results: Both CO and cSBP estimates were found to be in good agreement with the reference values achieving an RMSE of 0.36 L/min and 2.46 mmHg, respectively. Low biases were reported, namely -0.04 +/- 0.36 L/min for CO predictions and -0.27 +/- 2.51 mmHg for cSBP predictions. Significance: Our one-dimensional model can be successfully "tuned" to partially patient-specific standards by using noninvasive, easily obtained peripheral measurement data. The in vivo evaluation demonstrated that this method can potentially be used to obtain central aortic hemodynamic parameters in a noninvasive and accurate way.
Keywords
Biotechnology, Electrical and Electronic Engineering, Health Information Management, Computer Science Applications, Sensitivity, Brachytherapy, Mathematical model, Hemodynamics, Pressure measurement, Arteries, Noninvasive, cardiac output, central pressure, 1-D model, patient-specific models, optimization methods, MOBIL-O-GRAPH, CENTRAL BLOOD-PRESSURE, CENTRAL AORTIC PRESSURE, ONE-DIMENSIONAL MODEL, CARDIOVASCULAR-DISEASES, ELASTIC PROPERTIES, STROKE VOLUME, ARTERIAL, VALIDATION, FORM

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MLA
Bikia, Vasiliki, et al. “Noninvasive Cardiac Output and Central Systolic Pressure from Cuff-Pressure and Pulse Wave Velocity.” IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, vol. 24, no. 7, 2020, pp. 1968–81, doi:10.1109/jbhi.2019.2956604.
APA
Bikia, V., Pagoulatou, S., Trachet, B., Soulis, D., Protogerou, A., Papaioannou, T., & Stergiopulos, N. (2020). Noninvasive cardiac output and central systolic pressure from cuff-pressure and pulse wave velocity. IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 24(7), 1968–1981. https://doi.org/10.1109/jbhi.2019.2956604
Chicago author-date
Bikia, Vasiliki, Stamatia Pagoulatou, Bram Trachet, Dimitrios Soulis, Athanase Protogerou, Theodore Papaioannou, and Nikos Stergiopulos. 2020. “Noninvasive Cardiac Output and Central Systolic Pressure from Cuff-Pressure and Pulse Wave Velocity.” IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS 24 (7): 1968–81. https://doi.org/10.1109/jbhi.2019.2956604.
Chicago author-date (all authors)
Bikia, Vasiliki, Stamatia Pagoulatou, Bram Trachet, Dimitrios Soulis, Athanase Protogerou, Theodore Papaioannou, and Nikos Stergiopulos. 2020. “Noninvasive Cardiac Output and Central Systolic Pressure from Cuff-Pressure and Pulse Wave Velocity.” IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS 24 (7): 1968–1981. doi:10.1109/jbhi.2019.2956604.
Vancouver
1.
Bikia V, Pagoulatou S, Trachet B, Soulis D, Protogerou A, Papaioannou T, et al. Noninvasive cardiac output and central systolic pressure from cuff-pressure and pulse wave velocity. IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS. 2020;24(7):1968–81.
IEEE
[1]
V. Bikia et al., “Noninvasive cardiac output and central systolic pressure from cuff-pressure and pulse wave velocity,” IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, vol. 24, no. 7, pp. 1968–1981, 2020.
@article{8643414,
  abstract     = {Goal: We introduce a novel approach to estimate cardiac output (CO) and central systolic blood pressure (cSBP) from noninvasive measurements of peripheral cuff-pressure and carotid-to-femoral pulse wave velocity (cf-PWV). Methods: The adjustment of a previously validated one-dimensional arterial tree model is achieved via an optimization process. In the optimization loop, compliance and resistance of the generic arterial tree model as well as aortic flow are adjusted so that simulated brachial systolic and diastolic pressures and cf-PWV converge towards the measured brachial systolic and diastolic pressures and cf-PWV. The process is repeated until full convergence in terms of both brachial pressures and cf-PWV is reached. To assess the accuracy of the proposed framework, we implemented the algorithm on in vivo anonymized data from 20 subjects and compared the method-derived estimates of CO and cSBP to patient-specific measurements obtained with Mobil-O-Graph apparatus (central pressure) and two-dimensional transthoracic echocardiography (aortic blood flow). Results: Both CO and cSBP estimates were found to be in good agreement with the reference values achieving an RMSE of 0.36 L/min and 2.46 mmHg, respectively. Low biases were reported, namely -0.04 +/- 0.36 L/min for CO predictions and -0.27 +/- 2.51 mmHg for cSBP predictions. Significance: Our one-dimensional model can be successfully "tuned" to partially patient-specific standards by using noninvasive, easily obtained peripheral measurement data. The in vivo evaluation demonstrated that this method can potentially be used to obtain central aortic hemodynamic parameters in a noninvasive and accurate way.},
  author       = {Bikia, Vasiliki and Pagoulatou, Stamatia and Trachet, Bram and Soulis, Dimitrios and Protogerou, Athanase and Papaioannou, Theodore and Stergiopulos, Nikos},
  issn         = {2168-2194},
  journal      = {IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS},
  keywords     = {Biotechnology,Electrical and Electronic Engineering,Health Information Management,Computer Science Applications,Sensitivity,Brachytherapy,Mathematical model,Hemodynamics,Pressure measurement,Arteries,Noninvasive,cardiac output,central pressure,1-D model,patient-specific models,optimization methods,MOBIL-O-GRAPH,CENTRAL BLOOD-PRESSURE,CENTRAL AORTIC PRESSURE,ONE-DIMENSIONAL MODEL,CARDIOVASCULAR-DISEASES,ELASTIC PROPERTIES,STROKE VOLUME,ARTERIAL,VALIDATION,FORM},
  language     = {eng},
  number       = {7},
  pages        = {1968--1981},
  title        = {Noninvasive cardiac output and central systolic pressure from cuff-pressure and pulse wave velocity},
  url          = {http://dx.doi.org/10.1109/jbhi.2019.2956604},
  volume       = {24},
  year         = {2020},
}

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