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Systematic audiological assessment of auditory functioning in patients with Parkinson's disease

Kim De Keyser (UGent) , Miet De Letter (UGent) , Evelien De Groote (UGent) , Patrick Santens (UGent) , Durk Talsma (UGent) , Dick Botteldooren (UGent) and Annelies Bockstael (UGent)
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Abstract
Purpose: Alterations in primary auditory functioning have been reported in patients with Parkinson's disease (PD). Despite the current findings, the pathophysiological mechanisms underlying these alterations remain unclear, and the effect of dopaminergic medication on auditory functioning in PD has been explored insufficiently. Therefore, this study aimed to systematically investigate primary auditory functioning in patients with PD by using both subjective and objective audiological measurements. Method: In this case–control study, 25 patients with PD and 25 age-, gender-, and education-matched healthy controls underwent an audiological test battery consisting of tonal audiometry, short increment sensitivity index, otoacoustic emissions (OAEs), and speech audiometry. Patients with PD were tested in the on- and off-medication states. Results: Increased OAE amplitudes were found when patients with PD were tested without dopaminergic medication. In addition, speech audiometry in silence and multitalker babble noise demonstrated higher phoneme scores for patients with PD in the off-medication condition. The results showed no differences in auditory functioning between patients with PD in the on-medication condition and healthy controls. No effect of disease stage or motor score was evident. Conclusions: This study provides evidence for a top-down involvement in auditory processing in PD at both central and peripheral levels. Most important, the increase in OAE amplitude in the off-medication condition in PD is hypothesized to be linked to a dysfunction of the olivocochlear efferent system, which is known to have an inhibitory effect on outer hair cell functioning. Future studies may clarify whether OAEs may facilitate an early diagnosis of PD.

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MLA
De Keyser, Kim, et al. “Systematic Audiological Assessment of Auditory Functioning in Patients with Parkinson’s Disease.” JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, vol. 62, no. 12, 2019, pp. 4564–77.
APA
De Keyser, K., De Letter, M., De Groote, E., Santens, P., Talsma, D., Botteldooren, D., & Bockstael, A. (2019). Systematic audiological assessment of auditory functioning in patients with Parkinson’s disease. JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, 62(12), 4564–4577.
Chicago author-date
De Keyser, Kim, Miet De Letter, Evelien De Groote, Patrick Santens, Durk Talsma, Dick Botteldooren, and Annelies Bockstael. 2019. “Systematic Audiological Assessment of Auditory Functioning in Patients with Parkinson’s Disease.” JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH 62 (12): 4564–77.
Chicago author-date (all authors)
De Keyser, Kim, Miet De Letter, Evelien De Groote, Patrick Santens, Durk Talsma, Dick Botteldooren, and Annelies Bockstael. 2019. “Systematic Audiological Assessment of Auditory Functioning in Patients with Parkinson’s Disease.” JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH 62 (12): 4564–4577.
Vancouver
1.
De Keyser K, De Letter M, De Groote E, Santens P, Talsma D, Botteldooren D, et al. Systematic audiological assessment of auditory functioning in patients with Parkinson’s disease. JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH. 2019;62(12):4564–77.
IEEE
[1]
K. De Keyser et al., “Systematic audiological assessment of auditory functioning in patients with Parkinson’s disease,” JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, vol. 62, no. 12, pp. 4564–4577, 2019.
@article{8643030,
  abstract     = {Purpose: Alterations in primary auditory functioning have been reported in patients with Parkinson's disease (PD). Despite the current findings, the pathophysiological mechanisms underlying these alterations remain unclear, and the effect of dopaminergic medication on auditory functioning in PD has been explored insufficiently. Therefore, this study aimed to systematically investigate primary auditory functioning in patients with PD by using both subjective and objective audiological measurements.
Method: In this case–control study, 25 patients with PD and 25 age-, gender-, and education-matched healthy controls underwent an audiological test battery consisting of tonal audiometry, short increment sensitivity index, otoacoustic emissions (OAEs), and speech audiometry. Patients with PD were tested in the on- and off-medication states.
Results: Increased OAE amplitudes were found when patients with PD were tested without dopaminergic medication. In addition, speech audiometry in silence and multitalker babble noise demonstrated higher phoneme scores for patients with PD in the off-medication condition. The results showed no differences in auditory functioning between patients with PD in the on-medication condition and healthy controls. No effect of disease stage or motor score was evident.
Conclusions: This study provides evidence for a top-down involvement in auditory processing in PD at both central and peripheral levels. Most important, the increase in OAE amplitude in the off-medication condition in PD is hypothesized to be linked to a dysfunction of the olivocochlear efferent system, which is known to have an inhibitory effect on outer hair cell functioning. Future studies may clarify whether OAEs may facilitate an early diagnosis of PD.},
  author       = {De Keyser, Kim and De Letter, Miet and De Groote, Evelien and Santens, Patrick and Talsma, Durk and Botteldooren, Dick and Bockstael, Annelies},
  issn         = {1092-4388},
  journal      = {JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH},
  language     = {eng},
  number       = {12},
  pages        = {4564--4577},
  title        = {Systematic audiological assessment of auditory functioning in patients with Parkinson's disease},
  url          = {http://dx.doi.org/10.1044/2019_jslhr-h-19-009},
  volume       = {62},
  year         = {2019},
}

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