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The complex TIE between macrophages and angiogenesis

Charis Du Cheyne, Hanna Tay and Ward De Spiegelaere (UGent)
(2020) ANATOMIA HISTOLOGIA EMBRYOLOGIA. 49(5). p.585-596
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Abstract
Macrophages are primarily known as phagocytic immune cells, but they also play a role in diverse processes, such as morphogenesis, homeostasis and regeneration. In this review, we discuss the influence of macrophages on angiogenesis, the process of new blood vessel formation from the pre-existing vasculature. Macrophages play crucial roles at each step of the angiogenic cascade, starting from new blood vessel sprouting to the remodelling of the vascular plexus and vessel maturation. Macrophages form promising targets for both pro- and anti-angiogenic treatments. However, to target macrophages, we will first need to understand the mechanisms that control the functional plasticity of macrophages during each of the steps of the angiogenic cascade. Here, we review recent insights in this topic. Special attention will be given to the TIE2-expressing macrophage (TEM), which is a subtype of highly angiogenic macrophages that is able to influence angiogenesis via the angiopoietin-TIE pathway.
Keywords
angiogenesis, ANGPT-TIE pathway, macrophages, TIE2-signalling, TIE2-EXPRESSING MONOCYTES, TUMOR ANGIOGENESIS, VESSEL FORMATION, GENE-EXPRESSION, CELL-CELL, BLOOD, RECRUITMENT, NEOVASCULARIZATION, VASCULARIZATION, ANGIOPOIETIN-2

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MLA
Du Cheyne, Charis, et al. “The Complex TIE between Macrophages and Angiogenesis.” ANATOMIA HISTOLOGIA EMBRYOLOGIA, vol. 49, no. 5, 2020, pp. 585–96, doi:10.1111/ahe.12518.
APA
Du Cheyne, C., Tay, H., & De Spiegelaere, W. (2020). The complex TIE between macrophages and angiogenesis. ANATOMIA HISTOLOGIA EMBRYOLOGIA, 49(5), 585–596. https://doi.org/10.1111/ahe.12518
Chicago author-date
Du Cheyne, Charis, Hanna Tay, and Ward De Spiegelaere. 2020. “The Complex TIE between Macrophages and Angiogenesis.” ANATOMIA HISTOLOGIA EMBRYOLOGIA 49 (5): 585–96. https://doi.org/10.1111/ahe.12518.
Chicago author-date (all authors)
Du Cheyne, Charis, Hanna Tay, and Ward De Spiegelaere. 2020. “The Complex TIE between Macrophages and Angiogenesis.” ANATOMIA HISTOLOGIA EMBRYOLOGIA 49 (5): 585–596. doi:10.1111/ahe.12518.
Vancouver
1.
Du Cheyne C, Tay H, De Spiegelaere W. The complex TIE between macrophages and angiogenesis. ANATOMIA HISTOLOGIA EMBRYOLOGIA. 2020;49(5):585–96.
IEEE
[1]
C. Du Cheyne, H. Tay, and W. De Spiegelaere, “The complex TIE between macrophages and angiogenesis,” ANATOMIA HISTOLOGIA EMBRYOLOGIA, vol. 49, no. 5, pp. 585–596, 2020.
@article{8642606,
  abstract     = {{Macrophages are primarily known as phagocytic immune cells, but they also play a role in diverse processes, such as morphogenesis, homeostasis and regeneration. In this review, we discuss the influence of macrophages on angiogenesis, the process of new blood vessel formation from the pre-existing vasculature. Macrophages play crucial roles at each step of the angiogenic cascade, starting from new blood vessel sprouting to the remodelling of the vascular plexus and vessel maturation. Macrophages form promising targets for both pro- and anti-angiogenic treatments. However, to target macrophages, we will first need to understand the mechanisms that control the functional plasticity of macrophages during each of the steps of the angiogenic cascade. Here, we review recent insights in this topic. Special attention will be given to the TIE2-expressing macrophage (TEM), which is a subtype of highly angiogenic macrophages that is able to influence angiogenesis via the angiopoietin-TIE pathway.}},
  author       = {{Du Cheyne, Charis and Tay, Hanna and De Spiegelaere, Ward}},
  issn         = {{0340-2096}},
  journal      = {{ANATOMIA HISTOLOGIA EMBRYOLOGIA}},
  keywords     = {{angiogenesis,ANGPT-TIE pathway,macrophages,TIE2-signalling,TIE2-EXPRESSING MONOCYTES,TUMOR ANGIOGENESIS,VESSEL FORMATION,GENE-EXPRESSION,CELL-CELL,BLOOD,RECRUITMENT,NEOVASCULARIZATION,VASCULARIZATION,ANGIOPOIETIN-2}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{585--596}},
  title        = {{The complex TIE between macrophages and angiogenesis}},
  url          = {{http://doi.org/10.1111/ahe.12518}},
  volume       = {{49}},
  year         = {{2020}},
}
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