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The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : a review

(2020) EUROPEAN JOURNAL OF PEDIATRICS. 179(2). p.191-202
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Abstract
Cell-free DNA profiling using patient blood is emerging as a non-invasive complementary technique for cancer genomic characterization. Since these liquid biopsies will soon be integrated into clinical trial protocols for pediatric cancer treatment, clinicians should be informed about potential applications and advantages but also weaknesses and potential pitfalls. Small retrospective studies comparing genetic alterations detected in liquid biopsies with tumor biopsies for pediatric solid tumor types are encouraging. Molecular detection of tumor markers in cell-free DNA could be used for earlier therapy response monitoring and residual disease detection as well as enabling detection of pathognomonic and therapeutically relevant genomic alterations. Conclusion: Existing analyses of liquid biopsies from children with solid tumors increasingly suggest a potential relevance for molecular diagnostics, prognostic assessment, and therapeutic decision-making. Gaps remain in the types of tumors studied and value of detection methods applied. Here we review the current stand of liquid biopsy studies for pediatric solid tumors with a dedicated focus on cell-free DNA analysis. There is legitimate hope that integrating fully validated liquid biopsy-based innovations into the standard of care will advance patient monitoring and personalized treatment of children battling solid cancers.
Keywords
Liquid biopsies, Pediatric solid tumors, Cell-free DNA profiling, CELL-FREE DNA, MINIMAL RESIDUAL DISEASE, MISMATCH REPAIR DEFICIENCY, CENTRAL-NERVOUS-SYSTEM, MOLECULAR CLASSIFICATION, CANCER-PATIENTS, MESSENGER-RNAS, BONE-MARROW, NEUROBLASTOMA, AGE

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MLA
Van Paemel, Ruben, et al. “The Pitfalls and Promise of Liquid Biopsies for Diagnosing and Treating Solid Tumors in Children : A Review.” EUROPEAN JOURNAL OF PEDIATRICS, vol. 179, no. 2, 2020, pp. 191–202.
APA
Van Paemel, R., VLUG, R., De Preter, K., Van Roy, N., Speleman, F., Willems, L., … De Wilde, B. (2020). The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : a review. EUROPEAN JOURNAL OF PEDIATRICS, 179(2), 191–202.
Chicago author-date
Van Paemel, Ruben, ROSALIE VLUG, Katleen De Preter, Nadine Van Roy, Franki Speleman, Leen Willems, Tim Lammens, et al. 2020. “The Pitfalls and Promise of Liquid Biopsies for Diagnosing and Treating Solid Tumors in Children : A Review.” EUROPEAN JOURNAL OF PEDIATRICS 179 (2): 191–202.
Chicago author-date (all authors)
Van Paemel, Ruben, ROSALIE VLUG, Katleen De Preter, Nadine Van Roy, Franki Speleman, Leen Willems, Tim Lammens, Genevieve Laureys, Gudrun Schleiermacher, Godelieve AM Tytgat, Kathy Astrahantseff, Hedwig Deubzer, and Bram De Wilde. 2020. “The Pitfalls and Promise of Liquid Biopsies for Diagnosing and Treating Solid Tumors in Children : A Review.” EUROPEAN JOURNAL OF PEDIATRICS 179 (2): 191–202.
Vancouver
1.
Van Paemel R, VLUG R, De Preter K, Van Roy N, Speleman F, Willems L, et al. The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : a review. EUROPEAN JOURNAL OF PEDIATRICS. 2020;179(2):191–202.
IEEE
[1]
R. Van Paemel et al., “The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : a review,” EUROPEAN JOURNAL OF PEDIATRICS, vol. 179, no. 2, pp. 191–202, 2020.
@article{8642554,
  abstract     = {Cell-free DNA profiling using patient blood is emerging as a non-invasive complementary technique for cancer genomic characterization. Since these liquid biopsies will soon be integrated into clinical trial protocols for pediatric cancer treatment, clinicians should be informed about potential applications and advantages but also weaknesses and potential pitfalls. Small retrospective studies comparing genetic alterations detected in liquid biopsies with tumor biopsies for pediatric solid tumor types are encouraging. Molecular detection of tumor markers in cell-free DNA could be used for earlier therapy response monitoring and residual disease detection as well as enabling detection of pathognomonic and therapeutically relevant genomic alterations. 
Conclusion: Existing analyses of liquid biopsies from children with solid tumors increasingly suggest a potential relevance for molecular diagnostics, prognostic assessment, and therapeutic decision-making. Gaps remain in the types of tumors studied and value of detection methods applied. Here we review the current stand of liquid biopsy studies for pediatric solid tumors with a dedicated focus on cell-free DNA analysis. There is legitimate hope that integrating fully validated liquid biopsy-based innovations into the standard of care will advance patient monitoring and personalized treatment of children battling solid cancers.},
  author       = {Van Paemel, Ruben and VLUG, ROSALIE and De Preter, Katleen and Van Roy, Nadine and Speleman, Franki and Willems, Leen and Lammens, Tim and Laureys, Genevieve and Schleiermacher, Gudrun and Tytgat, Godelieve AM and Astrahantseff, Kathy and Deubzer, Hedwig and De Wilde, Bram},
  issn         = {0340-6199},
  journal      = {EUROPEAN JOURNAL OF PEDIATRICS},
  keywords     = {Liquid biopsies,Pediatric solid tumors,Cell-free DNA profiling,CELL-FREE DNA,MINIMAL RESIDUAL DISEASE,MISMATCH REPAIR DEFICIENCY,CENTRAL-NERVOUS-SYSTEM,MOLECULAR CLASSIFICATION,CANCER-PATIENTS,MESSENGER-RNAS,BONE-MARROW,NEUROBLASTOMA,AGE},
  language     = {eng},
  number       = {2},
  pages        = {191--202},
  title        = {The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : a review},
  url          = {http://dx.doi.org/10.1007/s00431-019-03545-y},
  volume       = {179},
  year         = {2020},
}

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