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Different patterns of cerebral and muscular tissue oxygenation 10 years after coarctation repair

Kristof Vandekerckhove (UGent) , Joseph Panzer (UGent) , Ilse Coomans (UGent) , Anneliese Moerman (UGent) , Katya De Groote (UGent) , Hans De Wilde (UGent) , Thierry Bové (UGent) , Katrien François, Daniël De Wolf (UGent) and Jan Boone (UGent)
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Abstract
The purpose of this study was to assess whether the lower exercise tolerance in children after coarctation repair is associated with alterations in peripheral tissue oxygenation during exercise. A total of 16 children after coarctation repair and 20 healthy control subjects performed an incremental ramp exercise test to exhaustion. Cerebral and locomotor muscle oxygenation were measured by means of near infrared spectroscopy. The responses of cerebral and muscle tissue oxygenation index (cTOI, mTOI), oxygenated (O(2)Hb), and deoxygenated hemoglobin (HHb) as a function of work rate were compared. Correlations between residual continuous wave Doppler gradients at rest, arm-leg blood pressure difference and local oxygenation responses were evaluated. Age, length, and weight was similar in both groups. Patients with aortic coarctation had lower peak power output (Ppeak) (72.3 +/- 20.2% vs. 106 +/- 18.7%, P < 0.001), VO(2)peak/kg (37.3 +/- 9.1 vs. 44.2 +/- 7.6 ml/kg, P = 0.019) and %VO(2)peak/kg (85.7 +/- 21.9% vs. 112.1 +/- 15.5%, P < 0.001). Cerebral O(2)Hb and HHb had a lower increase in patients vs. controls during exercise, with significant differences from 60 to 90% Ppeak (O(2)Hb) and 70% to 100% Ppeak (HHb). Muscle TOI was significantly lower in patients from 10 to 70% Ppeak and muscle HHb was significantly higher in patients vs. controls from 20 to 80% Ppeak. Muscle O(2)Hb was not different between both groups. There was a significant correlation between residual resting blood pressure gradient and Delta muscle HHb/Delta P at 10-20W and 20-30W (r = 0.40, P = 0.039 and r = 0.43, P = 0.034). Children after coarctation repair have different oxygenation responses at muscular and cerebral level. This reflects a different balance between O-2 supply to O-2 demand which might contribute to the reduced exercise tolerance in this patient population.
Keywords
coarctation aortae, near infrared spectroscopy, exercise test, children, muscle oxygenation, NEAR-INFRARED SPECTROSCOPY, TERM-FOLLOW-UP, MUSCLE DEOXYGENATION, INCREMENTAL EXERCISE, AORTIC COARCTATION, O-2 EXTRACTION, RAMP EXERCISE, BLOOD-FLOW, CHILDREN, BRAIN

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MLA
Vandekerckhove, Kristof, et al. “Different Patterns of Cerebral and Muscular Tissue Oxygenation 10 Years after Coarctation Repair.” FRONTIERS IN PHYSIOLOGY, vol. 10, 2019, doi:10.3389/fphys.2019.01500.
APA
Vandekerckhove, K., Panzer, J., Coomans, I., Moerman, A., De Groote, K., De Wilde, H., … Boone, J. (2019). Different patterns of cerebral and muscular tissue oxygenation 10 years after coarctation repair. FRONTIERS IN PHYSIOLOGY, 10. https://doi.org/10.3389/fphys.2019.01500
Chicago author-date
Vandekerckhove, Kristof, Joseph Panzer, Ilse Coomans, Anneliese Moerman, Katya De Groote, Hans De Wilde, Thierry Bové, Katrien François, Daniël De Wolf, and Jan Boone. 2019. “Different Patterns of Cerebral and Muscular Tissue Oxygenation 10 Years after Coarctation Repair.” FRONTIERS IN PHYSIOLOGY 10. https://doi.org/10.3389/fphys.2019.01500.
Chicago author-date (all authors)
Vandekerckhove, Kristof, Joseph Panzer, Ilse Coomans, Anneliese Moerman, Katya De Groote, Hans De Wilde, Thierry Bové, Katrien François, Daniël De Wolf, and Jan Boone. 2019. “Different Patterns of Cerebral and Muscular Tissue Oxygenation 10 Years after Coarctation Repair.” FRONTIERS IN PHYSIOLOGY 10. doi:10.3389/fphys.2019.01500.
Vancouver
1.
Vandekerckhove K, Panzer J, Coomans I, Moerman A, De Groote K, De Wilde H, et al. Different patterns of cerebral and muscular tissue oxygenation 10 years after coarctation repair. FRONTIERS IN PHYSIOLOGY. 2019;10.
IEEE
[1]
K. Vandekerckhove et al., “Different patterns of cerebral and muscular tissue oxygenation 10 years after coarctation repair,” FRONTIERS IN PHYSIOLOGY, vol. 10, 2019.
@article{8642407,
  abstract     = {{The purpose of this study was to assess whether the lower exercise tolerance in children after coarctation repair is associated with alterations in peripheral tissue oxygenation during exercise. A total of 16 children after coarctation repair and 20 healthy control subjects performed an incremental ramp exercise test to exhaustion. Cerebral and locomotor muscle oxygenation were measured by means of near infrared spectroscopy. The responses of cerebral and muscle tissue oxygenation index (cTOI, mTOI), oxygenated (O(2)Hb), and deoxygenated hemoglobin (HHb) as a function of work rate were compared. Correlations between residual continuous wave Doppler gradients at rest, arm-leg blood pressure difference and local oxygenation responses were evaluated. Age, length, and weight was similar in both groups. Patients with aortic coarctation had lower peak power output (Ppeak) (72.3 +/- 20.2% vs. 106 +/- 18.7%, P < 0.001), VO(2)peak/kg (37.3 +/- 9.1 vs. 44.2 +/- 7.6 ml/kg, P = 0.019) and %VO(2)peak/kg (85.7 +/- 21.9% vs. 112.1 +/- 15.5%, P < 0.001). Cerebral O(2)Hb and HHb had a lower increase in patients vs. controls during exercise, with significant differences from 60 to 90% Ppeak (O(2)Hb) and 70% to 100% Ppeak (HHb). Muscle TOI was significantly lower in patients from 10 to 70% Ppeak and muscle HHb was significantly higher in patients vs. controls from 20 to 80% Ppeak. Muscle O(2)Hb was not different between both groups. There was a significant correlation between residual resting blood pressure gradient and Delta muscle HHb/Delta P at 10-20W and 20-30W (r = 0.40, P = 0.039 and r = 0.43, P = 0.034). Children after coarctation repair have different oxygenation responses at muscular and cerebral level. This reflects a different balance between O-2 supply to O-2 demand which might contribute to the reduced exercise tolerance in this patient population.}},
  articleno    = {{1500}},
  author       = {{Vandekerckhove, Kristof and Panzer, Joseph and Coomans, Ilse and Moerman, Anneliese and De Groote, Katya and De Wilde, Hans and Bové, Thierry and François, Katrien and De Wolf, Daniël and Boone, Jan}},
  issn         = {{1664-042X}},
  journal      = {{FRONTIERS IN PHYSIOLOGY}},
  keywords     = {{coarctation aortae,near infrared spectroscopy,exercise test,children,muscle oxygenation,NEAR-INFRARED SPECTROSCOPY,TERM-FOLLOW-UP,MUSCLE DEOXYGENATION,INCREMENTAL EXERCISE,AORTIC COARCTATION,O-2 EXTRACTION,RAMP EXERCISE,BLOOD-FLOW,CHILDREN,BRAIN}},
  language     = {{eng}},
  pages        = {{10}},
  title        = {{Different patterns of cerebral and muscular tissue oxygenation 10 years after coarctation repair}},
  url          = {{http://dx.doi.org/10.3389/fphys.2019.01500}},
  volume       = {{10}},
  year         = {{2019}},
}

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