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Hepatitis B virus vaccination and revaccination response in children diagnosed with coeliac disease : a multicentre prospective study

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Organization
Abstract
Aim : This study evaluates hepatitis B virus (HBV) vaccination response in children with celiac disease (CD). Response in initial non-responders after a single booster vaccination as well as factors influencing HBV vaccination response were evaluated. Methodology : Anti-hepatitis B surface antibodies (a-HBsAB) were checked in all children with CD and a documented complete HBV vaccination. An a-HBsAB <10 U/L was considered as non-response. A single intramuscular HBV-vaccine booster was advised to all non-responders. Response was checked at the next appointment. Results : 133 children with CD were included, median age of 7.3 years (range 1.7-17.3) and 46 (35%) were male. The age at CD diagnosis was 6.0 years (range 1.1-15.7). HBV non-response was documented in 55% (n=73/133). No other factors were influencing the response. A booster was documented in 34/73 (47 %) initial non-responders (3 refused (4%), 36 (49%) had no follow up). Response after booster vaccination resulted in immunity in 22/34 (65%) and persisting non-response in 12/34 (35%). A single booster is able to reduce non-response from 55% (73/133) to 23% (22/94). Conclusion : A significantly lower immune response following HBV vaccination in children with CD was confirmed. A single intramuscular booster vaccination is able to induce a serologic response in two thirds of the initial non-responders. Control of HBV vaccination response has to become part of the follow-up in CD patients.
Keywords
celiac disease, hepatitis B, children, intradermal, vaccination, INTRADERMAL ROUTE, IMMUNE-RESPONSE, GLUTEN INTAKE, PREVALENCE, AGE

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MLA
ROUSSEFF, THAIS, et al. “Hepatitis B Virus Vaccination and Revaccination Response in Children Diagnosed with Coeliac Disease : A Multicentre Prospective Study.” ACTA GASTRO-ENTEROLOGICA BELGICA, vol. 82, no. 1, 2019, pp. 27–30.
APA
ROUSSEFF, T., CLAEYS, T., Van de Vijver, E., Moes, N., Vande Velde, S., Schelstraete, P., … Van Biervliet, S. (2019). Hepatitis B virus vaccination and revaccination response in children diagnosed with coeliac disease : a multicentre prospective study. ACTA GASTRO-ENTEROLOGICA BELGICA, 82(1), 27–30.
Chicago author-date
ROUSSEFF, THAIS, TANIA CLAEYS, Els Van de Vijver, N Moes, Saskia Vande Velde, Petra Schelstraete, Ruth De Bruyne, Myriam Van Winckel, and Stephanie Van Biervliet. 2019. “Hepatitis B Virus Vaccination and Revaccination Response in Children Diagnosed with Coeliac Disease : A Multicentre Prospective Study.” ACTA GASTRO-ENTEROLOGICA BELGICA 82 (1): 27–30.
Chicago author-date (all authors)
ROUSSEFF, THAIS, TANIA CLAEYS, Els Van de Vijver, N Moes, Saskia Vande Velde, Petra Schelstraete, Ruth De Bruyne, Myriam Van Winckel, and Stephanie Van Biervliet. 2019. “Hepatitis B Virus Vaccination and Revaccination Response in Children Diagnosed with Coeliac Disease : A Multicentre Prospective Study.” ACTA GASTRO-ENTEROLOGICA BELGICA 82 (1): 27–30.
Vancouver
1.
ROUSSEFF T, CLAEYS T, Van de Vijver E, Moes N, Vande Velde S, Schelstraete P, et al. Hepatitis B virus vaccination and revaccination response in children diagnosed with coeliac disease : a multicentre prospective study. ACTA GASTRO-ENTEROLOGICA BELGICA. 2019;82(1):27–30.
IEEE
[1]
T. ROUSSEFF et al., “Hepatitis B virus vaccination and revaccination response in children diagnosed with coeliac disease : a multicentre prospective study,” ACTA GASTRO-ENTEROLOGICA BELGICA, vol. 82, no. 1, pp. 27–30, 2019.
@article{8642323,
  abstract     = {Aim : This study evaluates hepatitis B virus (HBV) vaccination response in children with celiac disease (CD). Response in initial non-responders after a single booster vaccination as well as factors influencing HBV vaccination response were evaluated. 
Methodology : Anti-hepatitis B surface antibodies (a-HBsAB) were checked in all children with CD and a documented complete HBV vaccination. An a-HBsAB <10 U/L was considered as non-response. A single intramuscular HBV-vaccine booster was advised to all non-responders. Response was checked at the next appointment. 
Results : 133 children with CD were included, median age of 7.3 years (range 1.7-17.3) and 46 (35%) were male. The age at CD diagnosis was 6.0 years (range 1.1-15.7). HBV non-response was documented in 55% (n=73/133). No other factors were influencing the response. A booster was documented in 34/73 (47 %) initial non-responders (3 refused (4%), 36 (49%) had no follow up). Response after booster vaccination resulted in immunity in 22/34 (65%) and persisting non-response in 12/34 (35%). A single booster is able to reduce non-response from 55% (73/133) to 23% (22/94). 
Conclusion : A significantly lower immune response following HBV vaccination in children with CD was confirmed. A single intramuscular booster vaccination is able to induce a serologic response in two thirds of the initial non-responders. Control of HBV vaccination response has to become part of the follow-up in CD patients.},
  author       = {ROUSSEFF, THAIS and CLAEYS, TANIA and Van de Vijver, Els and Moes, N and Vande Velde, Saskia and Schelstraete, Petra and De Bruyne, Ruth and Van Winckel, Myriam and Van Biervliet, Stephanie},
  issn         = {1784-3227},
  journal      = {ACTA GASTRO-ENTEROLOGICA BELGICA},
  keywords     = {celiac disease,hepatitis B,children,intradermal,vaccination,INTRADERMAL ROUTE,IMMUNE-RESPONSE,GLUTEN INTAKE,PREVALENCE,AGE},
  language     = {eng},
  number       = {1},
  pages        = {27--30},
  title        = {Hepatitis B virus vaccination and revaccination response in children diagnosed with coeliac disease : a multicentre prospective study},
  volume       = {82},
  year         = {2019},
}

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